学術論文 |
- "Cleavage cascade of the sigma regulator FecR orchestrates TonB-dependent signal transduction ," bioRxiv, 8 Jan. 2025
- Tatsuhiko Yokoyama, Ryoji Miyazaki, Takehiro Suzuki, Naoshi Dohmae, Hiroki Nagai, Tomoya Tsukazaki, Tomoko Kubori, Yoshinori Akiyama
 [ doi:10.1101/2025.01.06.631622 ]
- "Structural basis of lipopolysaccharide translocon assembly mediated by the small lipoprotein LptM," bioRxiv, 4 Jan. 2025
- Ryoji Miyazaki, Mai Kimoto, KOHGA Hidetaka, Tomoya Tsukazaki
[ doi:10.1101/2025.01.03.631273 ]
- "AFM observation of protein translocation mediated by one unit of SecYEG-SecA complex," Nature Communications, vol.16, pp255, Jan. 2025
- Yui Kanaoka, Takaharu Mori, Wataru Nagaike, Seira Itaya, Yuto Nonaka, KOHGA Hidetaka, Takamitsu Haruyama, Yasunori Sugano, Ryoji Miyazaki, Muneyoshi Ichikawa, Takayuki Uchihashi, Tomoya Tsukazaki
[ doi:10.1038/s41467-024-54875-x ]
- "Translation arrest cancellation of VemP, a secretion monitor in Vibrio, is regulated by multiple cis- and trans-factors, including SecY," Journal of Biological Chemistry, Sep. 2024
- Yuki Ikeda, Ryoji Miyazaki, Tomoya Tsukazaki, Yoshinori Akiyama, Hiroyuki Mori
 [ NAISTレポジトリ ] [ doi:10.1016/j.jbc.2024.107735 ]
- "YeeD is an essential partner for YeeE-mediated thiosulfate uptake in bacteria and regulates thiosulfate ion decomposition," PLOS Biology, vol.22, ppe3002601, Apr. 2024
- Mai Ikei, Ryoji Miyazaki, Keigo Monden, Yusuke Naito, Azusa Takeuchi, Yutaro S. Takahashi, Yoshiki Tanaka, Keina Murata, Takaharu Mori, Muneyoshi Ichikawa, Tomoya Tsukazaki
[ doi:10.1371/journal.pbio.3002601 ]
- "Multistep conformational changes leading to the gate opening of light-driven sodium pump rhodopsin," Journal of Biological Chemistry, vol.299, no.12, pp105393, Dec. 2023
- Yukino Sato, Tsubasa Hashimoto, Koji Kato, Akiko Okamura, Kaito Hasegawa, Tsukasa Shinone, Yoshikazu Tanaka, Yoshiki Tanaka, Tomoya Tsukazaki, Takashi Tsukamoto, Makoto Demura, Min Yao, Takashi Kikukawa
- "Structure and function of a YeeE-YeeD complex for sophisticated thiosulfate uptake," bioRxiv, Jul. 2023
- Mai Ikei, Ryoji Miyazaki, Keigo Monden, Yusuke Naito, Azusa Takeuchi, Yutaro S. Takahashi, Yoshiki Tanaka, Takaharu Mori, Muneyoshi Ichikawa, Tomoya Tsukazaki
[ doi:10.1101/2023.07.28.550924 ]
- "Critical residues of the antibiotic peptide LysM that inhibits lipid II flipping," bioRxiv, May. 2023
- 甲賀 栄貴, Napathip Lertpreedakorn, Ryoji Miyazaki, Tomoya Tsukazaki
[ doi:10.1101/2023.05.22.541694 ]
- "Generation of stable microtubule superstructures by binding of peptide-fused tetrameric proteins to inside and outside," SCIENCE ADVANCES, vol.8, ppeabq3817, 7 Sep. 2022
- Hiroshi Inaba, Yurina Sueki, Muneyoshi Ichikawa, Arif Md. Rashedul Kabir, Takashi Iwasaki, Hideki Shigematsu, Akira Kakugo, Kazuki Sada, Tomoya Tsukazaki, Kazunori Matsuura
[ doi:10.1126/sciadv.abq3817 ]
- "Inner membrane YfgM–PpiD heterodimer acts as a functional unit that associates with the SecY/E/G translocon and promotes protein translocation," Journal of Biological Chemistry, vol.298, no.11, pp102572, Sep. 2022
- Ryoji Miyazaki, Mengting Ai, Natusko Tanaka, Takehiro Suzuki, Naoshi Dhomae, Tomoya Tsukazaki, Yoshinori Akiyama, Hiroyuki Mori
- "Crystal structure of the lipid flippase MurJ in a “squeezed” form distinct from its inward- and outward-facing forms," Structure, vol.30, pp1088-1097, 3 Jun. 2022
- Hidetaka Kohga, Takaharu Mori, Yoshiki Tanaka, Kunihito Yoshikaie, Katsuhide Taniguchi, Kei Fujimoto, Lisa Fritz, Tanja Schneider, Tomoya Tsukazaki
[ NAISTレポジトリ ] [ doi:10.1016/j.str.2022.05.008 ]
- "Crystal structures of a nicotine MATE transporter provide insight into its mechanism of substrate transport," FEBS Letters, vol.595, pp1902-1913, 29 May. 2021
- Yoshiki Tanaka, Shigehiro Iwaki, Akira Sasaki, Tomoya Tsukazaki
[ NAISTレポジトリ ] [ doi:10.1002/1873-3468.14136 ]
- "構造解析からみえてきたタンパク質膜透過駆動モーター膜タンパク質SecDFの仕組み," 生化学, vol.92, no.5, pp717-721, 2020.10.25
- 塚﨑 智也
[ doi:10.14952/SEIKAGAKU.2020.920717 ]
- "Reversible autoinhibitory regulation of Escherichia coli metallopeptidase BepA for selective β-barrel protein degradation," Proceedings of the National Academy of Sciences of the United States of America, 22 Oct. 2020
- Yasushi Daimon, Shin-ichiro Narita, Ryoji Miyazaki, Yohei Hizukuri, Hiroyuki Mori, Yoshiki Tanaka, Tomoya Tsukazaki, Yoshinori Akiyama
[ doi:10.1073/pnas.2010301117 ]
- "Crystal structure of a YeeE/YedE family protein engaged in thiosulfate uptake," SCIENCE ADVANCES, vol.6, ppeaba7637, 26 Aug. 2020
- Yoshiki Tanaka, Kunihito Yoshikaie, Azusa Takeuchi, Muneyoshi Ichikawa, Tomoyuki Mori, Sayaka Uchino, Yasunori Sugano, Toshio Hakoshima, Hiroshi Takagi, Gen Nonaka, Tomoya Tsukazaki
[ doi:10.1126/sciadv.aba7637 ]
- "A snapshot of membrane protein insertion," EMBO reports, vol.20, ppe49034, Oct. 2019
- Yoshiki Tanaka, Tomoya Tsukazaki
- "The bacterial protein YidC accelerates MPIase-dependent integration of membrane proteins," J. Biol. Chem., vol.in press, Oct. 2019
- Masaru Sasaki, Hanako Nishikawa, Sonomi Suzuki, Michael Moser, Maria Huber, Katsuhiro Sawasato, Hideaki Matsubayashi, Kaoru Kumazaki, Tomoya Tsukazaki, Yutetsu Kuruma, Osamu Nureki, Takuya Ueda, Ken-ichi Nishiyama
- "高速原子間力顕微鏡によるナノディスクを用いた膜タンパク質のリアルタイム動態観察," 野口研究所時報, vol.62, pp42-49, 2019.10
- 春山 隆充, 塚﨑 智也
- "Structural Basis of the Sec Translocon and YidC Revealed Through X-ray Crystallography," The Protein Journal, vol.38, pp249-261, Jun. 2019
- Tomoya Tsukazaki
[ NAISTレポジトリ ] [ doi:10.1007/s10930-019-09830-x ]
- "Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay," Cell Reports, vol.27, pp1221-1230, 23 Apr. 2019
- Michio Inoue, Nanami Sakuta, Satoshi Watanabe, Yuxia Zhang, Kunihito Yoshikaie, Yoshiki Tanaka, Ryo Ushioda, Yukinari Kato, Junichi Takagi, Tomoya Tsukazaki, Kazuhiro Nagata, Kenji Inaba
[ NAISTレポジトリ ] [ doi:10.1016/j.celrep.2019.03.106 ]
- "Structural Basis for the Function of the β-Barrel Assembly-Enhancing Protease BepA," Journal of Molecular Biology, vol.431, no.3, pp625-635, 1 Feb. 2019
- Mohammad Shahrizal, Yasushi Daimon, Yoshiki Tanaka, Yugo Hayashi, Shintaro Nakayama, Shigehiro Iwaki, Shin-ichiro Narita, Hironari Kamikubo, Yoshinori Akiyama, Tomoya Tsukazaki
[ NAISTレポジトリ ]
- "Single-Unit Imaging of Membrane Protein-Embedded Nanodiscs from Two Oriented Sides by High-Speed Atomic Force Microscopy," Structure, vol.27, no.1, pp152-160, 2 Jan. 2019
- Takamitsu Haruyama, Yasunori Sugano, Noriyuki Kodera, Takayuki Uchihashi, Toshio Ando, Yoshiki Tanaka, Hiroki Konno, Tomoya Tsukazaki
[ NAISTレポジトリ ]
- "2.8-Å crystal structure of Escherichia coli YidC revealing all core regions, including flexible C2 loop," Biochemical and Biophysical Research Communications, vol.505, no.1, pp141-145, 20 Oct. 2018
- Yoshiki Tanaka, Akiya Izumioka, Aisyah Abdul Hamid, Akira Fujii, Takamitsu Haruyama, Arata Furukawa, Tomoya Tsukazaki
[ NAISTレポジトリ ] [ doi:https://doi.org/10.1016/j.bbrc.2018.09.043 ]
- "Structure-based working model of SecDF, a proton-driven bacterial protein translocation factor," FEMS Microbiology Letters, vol.365, no.12, ppfny112, 27 Apr. 2018
- Tomoya Tsukazaki
[ NAISTレポジトリ ] [ doi:10.1093/femsle/fny112 ]
- "タンパク質膜透過装置の構造生物学," 生物物理, vol.58, pp78-82, 2018.4
- 塚﨑 智也
- "Remote Coupled Drastic beta-Barrel to beta-Sheet Transition of the Protein Translocation Motor," Structure, Mar. 2018
- Arata Furukawa, Shintaro Nakayama, Kunihito Yoshikaie, Yoshiki Tanaka, Tomoya Tsukazaki
[ NAISTレポジトリ ]
- "Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein," Structure, vol.25, no.9, pp1455-1460, 5 Sep. 2017
- Yoshiki Tanaka, Shigehiro Iwaki, Tomoya Tsukazaki
[ doi:10.1016/j.str.2017.07.009 ]
- "SecY-SecA fusion protein retains the ability to mediate protein transport," PLOS ONE, vol.12, ppe0183434, 18 Aug. 2017
- Yasunori Sugano, Arata Furukawa, Osamu Nureki, Yoshiki Tanaka, Tomoya Tsukazaki
[ doi:10.1371/journal.pone.0183434 ]
- "Tunnel Formation Inferred from the I-Form Structures of the Proton-Driven Protein Secretion Motor SecDF," Cell Reports, vol.19, pp895-901, 2 May. 2017
- Arata Furukawa, Kunihito Yoshikaie, Takaharu Mori, Hiroyuki Mori, Yusuke V. Morimoto, Yasunori Sugano, Shigehiro Iwaki, Tohru Minamino, Yuji Sugita, Yoshiki Tanaka, Tomoya Tsukazaki
[ doi:10.1016/j.celrep.2017.04.030 ]
- "タンパク質を膜透過させる分子装置の活写," 生化学, vol.88, no.1, pp114-118, 2016.2
- 塚﨑 智也
- "Crystal structures of SecYEG in lipidic cubic phase elucidate a precise resting and a peptide-bound states.," Cell Reports, 12 Nov. 2015
- Yoshiki Tanaka, Yasunori Sugano, Mizuki Takemoto, Takaharu Mori, Arata Furukawa, Tsukasa Kusakizako, Kaoru Kumazaki, Ayako Kashima, Ryuichiro Ishitani, Yuji Sugita, Osamu Nureki, Tomoya Tsukazaki
[ NAISTレポジトリ ]
- "Crystal structure of YidC reveals a mechanism of Sec-independent membrane protein," SPring-8 Research Frontiers 2014, pp26-27, Aug. 2015
- Kaoru Kumazaki, Tomoya Tsukazaki, Osamu Nureki
- "Hydrophilic microenvironment required for the channel-independent insertase function of YidC protein," Proc. Natl. Acad. Sci. USA, 9 Apr. 2015
- Naomi Shimokawa-Chiba, Kaoru Kumazaki, Tomoya Tsukazaki, Osamu Nureki, Koreaki Ito, Shinobu Chiba
[ NAISTレポジトリ ]
- "Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase," Scientific Reports, vol.4, pp7299-7299, 3 Dec. 2014
- Kaoru Kumazaki, Toshiki Kishimoto, Arata Furukawa, Hiroyuki Mori, Yoshiki Tanaka, Naoshi Dohmae, Ryuichiro Ishitani, Tomoya Tsukazaki, Osamu Nureki
[ NAISTレポジトリ ] [ doi:10.1038/srep07299 ]
- "Conformational variation of the translocon enhancing chaperone SecDF," Journal of Structural and Functional Genomics, vol.15, pp107-115, 1 Sep. 2014
- Kazuhiro Mio, Tomoya Tsukazaki, Hiroyuki Mori, Masaaki Kawata, Toshio Moriya, Yoshikazu Sasaki, Ryuichiro Ishitani, Koreaki Ito, Osamu Nureki, Chikara Sato
[ NAISTレポジトリ ] [ doi:10.1007/s10969-013-9168-4 ]
- "Crystallization and preliminary X-ray diffraction analysis of YidC, a membrane-protein chaperone and insertase from Bacillus halodurans.," Acta Crystallogr F Struct Biol Commun., vol.70, no.8, pp1056-60, 23 Jul. 2014
- Kumazaki K, Tsukazaki T, Nishizawa T, Tanaka Y, Kato HE, Nakada-Nakura Y, Hirata K, Mori Y, Suga H, Dohmae N, Ishitani R, Nureki O.
[ NAISTレポジトリ ] [ doi:10.1107/S2053230X14012540 ]
- "Structural basis of Sec-independent membrane protein insertion by YidC," Nature, vol.509, pp516-520, 22 May. 2014
- Kaoru Kumazaki, Shinobu Chiba, Mizuki Takemoto, Arata Furukawa, Ken-ichi Nishiyama, Yasunori Sugano, Takaharu Mori, Naoshi Dohmae, Kunio Hirata, Yoshiko Nakada-Nakura, Andrés D. Maturana, Yoshiki Tanaka, Hiroyuki Mori, Yuji Sugita, Fumio Arisaka, Koreaki Ito, Ryuichiro Ishitani, Tomoya Tsukazaki, Osamu Nureki
[ NAISTレポジトリ ] [ doi:10.1038/nature13167 ]
- "Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT," Proc. Natl Acad. Sci. USA , vol.110, no.28, pp11343-11348, 24 Jun. 2013
- Shintaro Doki, Hideaki E. Kato, Nicolae Solcan, Masayo Iwaki, Michio Koyama, Motoyuki Hattori, Norihiko Iwase, Tomoya Tsukazaki, Yuji Sugita, Hideki Kandori, Simon Newstead, Ryuichiro Ishitani, Osamu Nureki
[ NAISTレポジトリ ] [ doi:10.1073/pnas.1301079110 ]
- "Structural basis for the drug extrusion mechanism by a MATE multidrug transporter," Nature, vol.496, pp247-251, 11 Apr. 2013
- Yoshiki Tanaka, Christopher J. Hipolito, Andrés D. Maturana, Koichi Ito, Teruo Kuroda, Takashi Higuchi, Takayuki Katoh, Hideaki E. Kato, Motoyuki Hattori, Kaoru Kumazaki, Tomoya Tsukazaki, Ryuichiro Ishitani, Hiroaki Suga, Osamu Nureki
[ NAISTレポジトリ ] [ doi:10.1038/nature12014 ]
- "Crystal structure of the channelrhodopsin light-gated cation channel," Nature, pp369-374, 22 Jan. 2012
- Kato E H, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S, Hegemann P, Maturana AD, Ishitani R, Deisseroth K, Nureki O
[ doi:10.1038/nature10870 ]
- "The mechanism of protein export enhancement by the SecDF membrane component," BIOPHYSICS, pp129-133, 30 Nov. 2011
- Tsukazaki T, Nureki O
- "Crystallization and preliminary X-ray diffraction of the first periplasmic domain of SecDF, a translocon-associated membrane protein, from Thermus thermophilus," Biol. Cryst. Commun, pp1367-1370, 27 Oct. 2011
- Echizen Y, Tsukazaki T, Dohmae N, Ishitani R, Nureki O
[ doi:10.1107/S1744309111031885 ]
- "Molecular mechanisms underlying the early stage of protein translocation through the Sec translocon.," Biochemistry., vol.49, no.5, pp945-950, 9 Feb. 2010
- Mori T, Ishitani R, Tsukazaki T, Nureki O, Sugita Y.
[ doi:10.1021/bi901594w ]
- " Molecular mechanisms underlying the early stage of protein translocation through the Sec translocon," Biochemistry , pp945-950, 7 Jan. 2010
- Mori T, Ishitani R, Tsukazaki T, Nureki O, Sugita Y
[ doi:10.1021/bi901594w ]
- "Mg2+-dependent gating of bacterial MgtE channel underlies Mg2+ homeostasis," EMBO J, pp3602-3612, 18 Nov. 2009
- Hattori M, Iwase N, Furuya N, Tanaka Y, Tsukazaki T, Ishitani R, Maguire ME, Ito K, Nureki O
[ doi:10.1038/emboj.2009.288 ]
- "Conformational transition of Sec machinery inferred from bacterial SecYE structures," Nature, pp988-991, 10 Sep. 2008
- Tomoya Tsukazaki, Hiroyuki Mori, Shuya Fukai, Ryuichiro Ishitani, Takaharu Mori, Naoshi Dohmae, Anna Perederina, Yuji Sugita, Dmitry G.Vassylyev, Koreaki Ito, Osamu Nureki
[ doi:10.1038/nature07421 ]
- "Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals a parallel, head-to-head dimer," J. Mol. Biol, pp248-258, 1 Dec. 2006
- Vassylyev DG, Mori H, Vassylyeva MN, Tsukazaki T, Kimura Y, Tahirov TH, Ito K.
- "Cloning, expression, purification, crystallization and initial crystallographic analysis of the preprotein translocation ATPase SecA from Thermus thermophilus. Acta. Crystallograph. Sect. F. Struct. ," Biol. Cryst. Commun, pp909-912, 1 Sep. 2006
- Vassylyeva MN, Mori H, Tsukazaki T, Yokoyama S, Tahirov TH, Ito K, Vassylyev DG
[ doi:10.1107/S1744309106030843 ]
- "Purification, crystallization and preliminary X-ray diffraction of SecDF, a translocon-associated membrane protein, from Thermus thermophilus," Biol. Cryst. Commun, pp376-380, 25 Mar. 2006
- Tsukazaki T, Mori H, Fukai S, Numata T, Perederina A, Adachi H, Matsumura H, Takano K, Murakami S, Inoue T, Mori Y, Sasaki T, Vassylyev DG, Nureki O, Ito K
[ doi:10.1107/S1744309106007779 ]
- "Fluorescence resonance energy transfer analysis of protein translocase. SecYE from Thermus thermophilus HB8 forms a constitutive oligomer in membranes," J. Biol. Chem, pp14257-14264, 9 Jan. 2003
- Mori H, Tsukazaki T, Masui R, Kuramitsu S, Yokoyama S, Johnson AE, Kimura Y, Akiyama Y, Ito K
- "Interactions of cytochrome c peroxidase with lysine peptides," Biochem. Biophys. Res. Commun, pp395-397, 16 Feb. 2000
- Hirota S, Tsukazaki T, Yamauchi O
- "Interactions of Cytochrome c and Cytochrome f with Aspartic Acid Peptides," J. Am. Chem. Soc, pp849-855, Jan. 1999
- Hirota S, Endo M, Hayamizu K, Tsukazaki T, Takabe T, Kohzuma T, Yamauchi O
- "Effects of charged peptides on electron transfer from [Fe(CN)6]4- to cytochrome c or plastocyanin," J. Biol. Inor. Chem, pp563-569, Dec. 1998
- Hirota S, Endo M, Tsukazaki T, Takabe T, Yamauchi O
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