北野 健

所属 バイオサイエンス領域 統合システム生物学分野
職位 助教
学位
研究室 構造生命科学
研究キーワード
研究分野
研究室概要
生命現象には蛋白質やRNAなど様々な分子が関わっている。これらが織りなすダイナミックな構造変化に起因する分子メカニズムを原子レベルで明らかとすべく,新たな研究手法を組み合わせた構造生物学的解析による基盤研究・教育を行う。
学術論文
"Free Flavin Participates in Iron and Also Oxygen Metabolism in Bacteria," Journal of Bacteriology & Parasitology, vol.11, no.4, pp1000377, 4 Aug. 2020
Tomonori Suzuki, Akira Abe, Shinji Kawasaki, Masataka Uchino, Etsuo Yoshimura, Akio Watanabe, Ken Kitano, Daichi Mochizuki, Kouji Takeda, Junichi Satoh, Shinya Kimata, Youichi Niimura
[ doi:10.35248/2155-9597.20.11.377 ]
"Intracellular free flavin and its associated enzymes participate in oxygen and iron metabolism in Amphibacillus xylanus lacking a respiratory chain.," FEBS Open Bio., vol.8, no.6, pp947-961, 9 May. 2018
Shinya Kimata, Daichi Mochizuki, Junichi Satoh, Ken Kitano, Yu Kanesaki, Kouji Takeda, Akira Abe, Shinji Kawasaki, Youichi Niimura
"MT1-MMP recognition by ERM proteins and its implication in CD44 shedding," Genes Cells., 20 Aug. 2015
Terawaki SI, Ken Kitano, Aoyama M, Tomoyuki Mori, Toshio Hakoshima
[ doi:10.1111/gtc.12276 ]
"Structural mechanisms of human RecQ helicases WRN and BLM.," Front. Genet., vol.5, pp366, 29 Oct. 2014
Ken Kitano
[ NAISTレポジトリ ] [ doi:10.3389/fgene.2014.00366 ]
"環状ペプチドによる三量体Gタンパク質の新しい阻害機構.," 生物物理, vol.54, no.5, pp265-266, 2014.10.1
北野 健
[ NAISTレポジトリ ]
"ヒトRecQヘリカーゼWRNとBLMの結晶構造解析.," 日本結晶学会誌, vol.56, no.2, pp133-138, 2014.5.1
北野 健
[ NAISTレポジトリ ]
"Structure of the RecQ C-terminal domain of human Bloom syndrome protein.," Scientific Report, vol.3, pp3294, 21 Nov. 2013
Sun-Yong Kim, Toshio Hakoshima, Ken Kitano
[ NAISTレポジトリ ]
"Solution structure of the HRDC domain of human Bloom syndrome protein BLM.," J. Biochem., vol.148, no.4, pp517-525, Oct. 2010
Akiko Sato, Masaki Mishima, Aki Nagai, Sun-Yong Kim, Yutaka Ito, Toshio Hakoshima, Jun-Goo Jee, Ken Kitano
"Solution structure of the HRDC domain of human Bloom syndrome protein BLM.," J. Biochem., vol.148, no.4, pp517, Oct. 2010
Akiko Sato, Masaki Mishima, Aki Nagai, Sun-Yong Kim, Yutaka Ito, Toshio Hakoshima, Jun-Goo Jee, Ken Kitano
[ doi:10.1093/jb/mvq097 ]
"Solution structure of the HRDC domain of human Bloom syndrome protein BLM.," J. Biochem., vol.148, no.4, pp517, Oct. 2010
Akiko Sato, Masaki Mishima, Aki Nagai, Sun-Yong Kim, Yutaka Ito, Toshio Hakoshima, Jun-Goo Jee, Ken Kitano
[ doi:10.1093/jb/mvq097 ]
"早老症の原因タンパク質WRNがDNAをほどく仕組み," シーエンス, vol.9, pp3-4, 2010.9
北野 健
"Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.," Proc. Natl. Acad. Sci. USA., vol.107, no.31, pp13666-13671, 3 Aug. 2010
Akiyuki Nishimura, Ken Kitano, Jun Takasaki, Masatoshi Taniguchi, Norikazu Mizuno, Kenji Tago, Toshio Hakoshima, Hiroshi Itoh
"Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule," Proc Natl Acad SciUSA, vol.107, no.31, pp13666-13671, Aug. 2010
Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H.
[ doi:10.1073/pnas.1003553107 ]
"Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN," Structure, vol.18, no.2, pp177-187, 10 Feb. 2010
Ken Kitano, Sun-Yong Kim, Toshio Hakoshima
"Structural Basis for DNA Strand Separation by the Unconventional Winged-Helix Domain of RecQ Helicase WRN.," Structure, vol.18, no.2, pp177, Feb. 2010
Kitano, K, Kim, S. Y. Hakoshima, T.
[ doi:10.1016/j.str.2009.12.011 ]
"Structural Basis for DNA Strand Separation by the Unconventional Winged-Helix Domain of RecQ Helicase WRN.," Structure, vol.18, no.2, pp177, Feb. 2010
Kitano, K, Kim, S. Y. Hakoshima, T.
[ doi:10.1016/j.str.2009.12.011 ]
"The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.," EMBO J., vol.29, no.1, pp236-250, Jan. 2010
Shin-ichi Terawaki, Ken Kitano, Tomoyuki Mori, Yan Zhai, Yoshiki Higuchi, Norimichi Itoh, Takashi Watanabe, Kozo Kaibuchi, Toshio Hakoshima
"The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module," EMBO J., vol.29, no.1, pp236, Jan. 2010
Terawaki, S, Kitano, K, Mori, T, Zhai, Y, Higuch, Y, Itoh, N, Watanabe, T, Kaibuchi, K, *Hakoshima, T.
[ doi:10.1038/emboj.2009.323 ]
"The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module," EMBO J., vol.29, no.1, pp236, Jan. 2010
Terawaki, S, Kitano, K, Mori, T, Zhai, Y, Higuch, Y, Itoh, N, Watanabe, T, Kaibuchi, K, *Hakoshima, T.
[ doi:10.1038/emboj.2009.323 ]
"Crystallographic characterization of the membrane-targeting domain of Rac-specific guanine nucleotide exchange factors Tiam1 and 2.," Acta Crystallogr. F, vol.F64, no.11, pp1039-1042, Nov. 2008
Shin-ichi Terawaki, Ken Kitano, Toshio Hakoshima
"Crystallographic characterization of the membrane-targeting domain of Rac-specific guanine nucleotide exchange factors Tiam1 and 2.," Acta Cryst. F, vol.64, no.11, pp1039, Nov. 2008
Shin-ichi Terawaki, Ken Kitano, Toshio Hakoshima
[ doi:10.1107/S1744309108031692 ]
"Crystallographic characterization of the membrane-targeting domain of Rac-specific guanine nucleotide exchange factors Tiam1 and 2.," Acta Cryst. F, vol.64, no.11, pp1039, Nov. 2008
Shin-ichi Terawaki, Ken Kitano, Toshio Hakoshima
[ doi:10.1107/S1744309108031692 ]
"Structural Basis for CD44 Recognition by ERM Proteins," J. Biol. Chem., vol.283, no.43, pp29602-29612, 24 Oct. 2008
Tomoyuki Mori, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Yayoi Fukami, Toshio Hakoshima
"Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of membrane-type 1 matrix metalloproteinase (MT1-MMP)," Acta Crystallogr. F, vol.64, no.1, pp39-43, Oct. 2008
Shin-ichi Terawaki, Ken Kitano, Miki Aoyama, Toshio Hakoshima
"Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of membrane-type 1 matrix metalloproteinase (MT1-MMP)," Acta Cryst. F, vol.64, no.10, pp911, Oct. 2008
Shin-ichi Terawaki, Ken Kitano, Miki Aoyama, Toshio Hakoshima
[ doi:10.1107/S1744309108026869 ]
"Structural basis for CD44 recognition by ERM proteins.," J. Biol. Chem., vol.283, no.43, pp29602, Oct. 2008
Tomoyuki Mori, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Yayoi Fukami, Toshio Hakoshima
[ doi:10.1074/jbc.M803606200 ]
"Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of membrane-type 1 matrix metalloproteinase (MT1-MMP)," Acta Cryst. F, vol.64, no.10, pp911, Oct. 2008
Shin-ichi Terawaki, Ken Kitano, Miki Aoyama, Toshio Hakoshima
[ doi:10.1107/S1744309108026869 ]
"Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins.," J. Mol. Biol., vol.381, no.3, pp634-644, 5 Sep. 2008
Yumiko Takai, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Toshio Hakoshima
"Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins.," J. Mol. Biol., vol.381, no.3, pp634, Sep. 2008
YumikoTakai, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Toshio Hakoshima
[ doi:10.1016/j.jmb.2008.05.085 ]
"Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins.," J. Mol. Biol., vol.381, no.3, pp634, Sep. 2008
YumikoTakai, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Toshio Hakoshima
[ doi:10.1016/j.jmb.2008.05.085 ]
"Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease-1 FEN1 in complex with a nicked DNA product: Use of a DPCS kit for efficient protein-DNA complex crystallization.," Acta Crystallogr. F, vol.64, no.1, pp39-43, Jan. 2008
Shigeru Sakurai, Ken Kitano, Hiroshi Morioka, Toshio Hakoshima
"Structural basis of PSGL-1 binding to ERM proteins. ," Genes to Cells, vol.12, no.12, pp1329-1338, Dec. 2007
Yumiko Takai, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Toshio Hakoshima
"Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease 1 in complex with a nicked DNA product: use of a DPCS kit for efficient protein-DNA complex crystallization.," Acta Crystallogr Sect F Struct Biol Cryst Commun, vol.64, pp39, Dec. 2007
Sakurai, S, Kitano, K, Morioka, H, Hakoshima, T.
[ doi:10.1107/s1744309107065372 ]
"Structural basis of PSGL-1 binding to ERM proteins.," Genes Cells, vol.12, pp1329, Dec. 2007
Takai, Y, Kitano, K, Terawaki, S, Maesaki, R, Hakoshima, T.
[ doi:10.1111/j.1365-2443.2007.01137.x ]
"Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease 1 in complex with a nicked DNA product: use of a DPCS kit for efficient protein-DNA complex crystallization.," Acta Crystallogr Sect F Struct Biol Cryst Commun, vol.64, pp39, Dec. 2007
Sakurai, S, Kitano, K, Morioka, H, Hakoshima, T.
[ doi:10.1107/s1744309107065372 ]
"Crystallographic characterization of the radixinFERM domain bound to the cytoplasmic tail of adhesion molecule CD44.," Acta Crystallogr. F, vol.63, no.10, pp844-847, Oct. 2007
Tomoyuki Mori, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Toshio Hakoshima
"Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of adhesion molecule CD44.," Acta Crystallogr Sect F Struct Biol Cryst Commun, vol.63, pp844, Oct. 2007
Mori, T, Kitano, K, Terawaki, S, Maesaki, R, Hakoshima, T.
[ doi:10.1107/s1744309107041152 ]
"Structural basis for type II membrane protein binding by ERM proteins revealed by the radixin-neutral endopeptidase 24.11 (NEP) complex.," J. Biol. Chem., vol.282, no.27, pp19854-19862, 6 Jul. 2007
Shin-ichi Terawaki, Ken Kitano, Toshio Hakoshima
"Structural basis for type II membrane protein binding by ERM proteins revealed by the radixin-neutral endopeptidase 24.11 (NEP) complex.," J Biol Chem, vol.282, pp19854, Jul. 2007
Terawaki, S. I, Kitano, K., Hakoshima, T.
[ doi:10.1074/jbc.M609232200 ]
"Structural basis for type II membrane protein binding by ERM proteins revealed by the radixin-neutral endopeptidase 24.11 (NEP) complex.," J Biol Chem, vol.282, pp19854, Jul. 2007
Terawaki, S. I, Kitano, K., Hakoshima, T.
[ doi:10.1074/jbc.M609232200 ]
"Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer.," J. Biochem., vol.141, no.6, pp889-895, Jun. 2007
Tomonori G. Nishino, Ken Kitano, Katsuhiko Kojima, Tadashi Ogishima, Akio Ito, Sakae Kitada
"Crystal structure of the HRDC domain of human Werner syndrome protein, WRN.," J. Biol. Chem., vol.282, no.4, pp2717-2728, 26 Jan. 2007
Ken Kitano, Nozomi Yoshihara, Toshio Hakoshima
"Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tails of adhesion molecules CD43 and PSGL-1.," Acta Crystallogr., F, vol.63, no.1, pp49-51, Jan. 2007
Yumiko Takai, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Toshio Hakoshima
"Crystal structure of human flap endonuclease-1 (FEN1) complexed to PCNA," SPring-8 Research Frontiers, pp18-19, Nov. 2006
Ken Kitano, Shigeru Sakurai, Toshio Hakoshima
"ヒトFEN1-PCNA複合体の結晶構造が示すスイング活性化機構," 日本結晶学会誌, vol.48, no.10, ppin press, 2006.10
北野 健, 箱嶋 敏雄
"Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632," J. Biochem., vol.140, no.3, pp305-311, Sep. 2006
Hiroto Yamaguchi, Yukiko Miwa, Miyuki Kasa, Ken Kitano, Mutsuki Amano, Kozo Kaibuchi, Toshio Hakoshima
"Crystal structure of human Rad GTPase of the RGK-family.," Genes Cells, vol.11, no.8, pp961-968, Aug. 2006
Arry Yanuar, Shigeru Sakurai, Ken Kitano, Toshio Hakoshima
"Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295–304.," Acta Crystallogr. F, vol.F62, no.4, pp340-345, Apr. 2006
Ken Kitano, Fumie Yusa, Toshio Hakoshima
"Expression, purification, crystallization and preliminarycrystallographic analysis of human Rad GTPase," Acta Crystallogr. F, vol.61, no.11, pp978-980, Nov. 2005
Arry Yanuar, Shigeru Sakurai, Ken Kitano, Toshio Hakoshima
"Crystal structure of decameric peroxiredoxin (AhpC) from Amphibacillusxylanus.," Proteins, vol.59, no.3, pp644-647, May. 2005
Ken Kitano, Akiko Kita, Toshio Hakoshima, Youichi Niimura, Kunio Miki
"Structural basis for recruitment of human flap endonuclease 1 to PCNA.," EMBO J., vol.24, no.4, pp683-693, Apr. 2005
Shigeru Sakurai, Ken Kitano, Hiroto Yamaguchi, Kengo Okada, Keisuke Hamada, Kotaro Fukuda, Makiyo Uchida, Eiko Ohtsuka, Hiroshi Morioka, Toshio Hakoshima
"微小重力下でのタンパク質結晶化と放射光による構造解析," 日本マイクログラビティ応用学会誌, vol.22, no.2, pp78-85, 2005
北野 健, 沼本修孝, 三木邦夫
"Preparation and crystallization of human flap endonuclease FEN-1 in complex with proliferating-cell nuclear antigen, PCNA.," Acta Crystallogr. D, vol.59, no.5, pp933-935, May. 2003
Shigeru Sakurai, Ken Kitano, Kengo Okada, Keisuke Hamada, Hiroshi Morioka, Toshio Hakoshima
受賞
"住友財団 基礎科学研究助成," 住友財団, 2008.10.16
北野 健
"第4回 梅園賞," 奈良先端科学技術大学院大学 バイオサイエンス研究科, 2007.7.26
北野 健
"稲盛財団 研究助成," 稲盛財団, 2007.4.22
北野 健
"上原記念生命科学財団 研究奨励金," 上原記念生命科学財団, 2007.3.9
北野 健
所属学協会
資料

塚崎 智也

職位 教授
領域 バイオサイエンス領域 統合システム生物学分野
研究室 構造生命科学

生命現象には蛋白質やRNAなど様々な分子が関わっている。これらが織りなすダイナミックな構造変化に起因する分子メカニズムを原子レベルで明らかとすべく,新たな研究手法を組み合わせた構造生物学的解析による基盤研究・教育を行う。

宮﨑 亮次

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 構造生命科学

生命現象には蛋白質やRNAなど様々な分子が関わっている。これらが織りなすダイナミックな構造変化に起因する分子メカニズムを原子レベルで明らかとすべく,新たな研究手法を組み合わせた構造生物学的解析による基盤研究・教育を行う。

甲賀 栄貴

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 構造生命科学

生命現象には蛋白質やRNAなど様々な分子が関わっている。これらが織りなすダイナミックな構造変化に起因する分子メカニズムを原子レベルで明らかとすべく,新たな研究手法を組み合わせた構造生物学的解析による基盤研究・教育を行う。