研究キーワード
構造生物学, Structural Biology
研究分野
ライフサイエンス / 構造生物化学 /
研究室概要
蛋白質分子集団が示す自律的集合離散現象に注目し、蛋白質科学及び生物物理学を基礎として、創薬のターゲットとなり得る蛋白質分子複合系の理解や次世代蛋白質分子複合材料の開発に関する研究・教育を行う。
学術論文
"Structural insight into the nuclear transportation mechanism of PPARg by Transportin-1," Cold Spring Harbor Laboratory, 17 Sep. 2024
Sachiko Toma, Yutaro Nakamura, Akihiro Kawamoto, Hikaru Shimizu, Koki Hayama, Ruri Kojima, Kanami Yoshimura, Masaki Ishii, Mika Hirose, Toshiaki Teratani, Shinya Ohata, Takayuki Kato, Hironari Kamikubo, Toshimasa Itoh, Kengo Tomita, Toshiyuki Shimizu
[ doi:10.1101/2024.09.17.612794 ]
"Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets," Acta Crystallogr D Struct Biol, 1 Oct. 2023
Hiroaki Matsuura, Naoki Sakai, Sachiko Toma, Norifumi Muraki, Koki Hayama, Hironari Kamikubo, Shigetoshi Aono, Yoshiaki Kawano, Masaki Yamamoto, Kumio Hirata
[ doi:10.1107/S20597983230070 ]
"Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.," Scientific reports, vol.13, pp16456-16456, 30 Sep. 2023
Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, Yasuo Watanabe, Takao Otsuka, Hiroaki Saito, Satoru Nagatoishi, Kouhei Tsumoto, Hirotatsu Kojima, Takayoshi Okabe, Toshiyuki Shimizu, Yasuteru Urano
[ doi:10.1038/s41598-023-43536-6 ]
"Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation.," 2023.5.29
藤間 祥子, Yuto Sawada, Ayako Maeda, Hikaru Shimizu, Toshiharu Shikanai, Mizuki Takenaka, Toshiyuki Shimizu
[ doi:10.1093/plcell/koac318 ]
"Difference in the Inhibitory Effect of Thiol Compounds and Demetallation Rates from the Zn(II) Active Site of Metallo-β-lactamases (IMP-1 and IMP-6) Associated with a Single Amino Acid Substitution.," ACS infectious diseases, vol.9, pp65-78, 13 Jan. 2023
Yoshihiro Yamaguchi, Koichi Kato, Yoshimi Ichimaru, Yuya Uenosono, Sakiko Tawara, Rio Ito, Natsuki Matsuse, Jun-Ichi Wachino, Sachiko Toma, Wanchun Jin, Yoshichika Arakawa, Masami Otsuka, Mikako Fujita, Nobuyuki Fukuishi, Kirara Sugiura, Masanori Imai, Hiromasa Kurosaki
[ doi:10.1021/acsinfecdis.2c00395 ]
"Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation," The Plant cell, 7 Nov. 2022
Sachiko Toma, Yuto Sawada, Ayako Maeda, Hikaru Shimizu, Toshiharu Shikanai, Mizuki Takenaka, Toshiyuki Shimizu
[ doi:10.1093/plcell/koac318. ]
"Structural Diversity of Ubiquitin E3 Ligase.," Molecules (Basel, Switzerland), vol.26-21, 4 Nov. 2021
Sachiko Toma, Toshiyuki Shimizu
[ doi:10.3390/molecules26216682 ]
"C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers," Nature Communications, vol.12-1, 2021.9.6
Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara, Takeru Uehara, Yuichiro Aiba, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Pattama Wiriyasermkul, Sotaro Kikuchi, Riko Nagata, Masaya Matsubayashi, Yoichi Shinkai, Tatsuya Niwa, Taro Mannen, Naritaka Morikawa, Naohiko Iguchi, Takao Kiriyama, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Takashi Oda, Noriyuki Kodera, 藤間 祥子, Mamoru Sato, Hideki Taguchi, Shushi Nagamori, Osami Shoji, Koichiro Ishimori, Hiroyoshi Matsumura, Kazuma Sugie, Tomohide Saio, Takuya Yoshizawa, Eiichiro Mori
[ doi:10.1038/s41467-021-25560-0 ]
"Structure elements can be predicted using the contact Volume among protein residues," Biophysics and Physicobiology, vol.v18.006, pp50-59, 18 Feb. 2021
Yasumichi Takase, Yoichi Yamazaki, Yugo Hayashi, Sachiko Toma, Hironari Kamikubo
[ doi:10.2142/biophysico ]
"Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling," FREE RADIC. BIOL. MED, pp45-56, 20 Aug. 2020
Toshiaki Teratani, Kengo Tomita, Sachiko Toma, Yutaro Nakamura, Toshimasa Itoh, Hikaru Shimizu, Yasunaga Shiraishi, Nao Sugihara, Masaaki Higashiyama, Takahiko Shimizu, Ikuo Inoue, Yasuhiro Takenaka, Ryota Hokari, Takeshi Adachi, Toshiyuki Shimizu, Soichiro Miura, Takanori Kanai
[ doi:10.1016/j.freeradbiomed.2020.06.005 ]
"Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure," J.Biol.Chem, 19 Aug. 2020
Sachiko Toma
[ doi:10.1074/jbc.RA120.013431 ]
"Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity," Sci Rep., 2020.3
藤間 祥子
[ doi:10.1038/s41598-020-61972-6 ]
"Structural Insights into the Regulation Mechanism of Small GTPases by GEFs," Molecules, vol.24(18), pp3308-3308, 11 Sep. 2019
Sachiko Toma-Fukai, Toshiyuki Shimizu
[ doi:10.3390/molecules24183308 ]
"Bio-SAXSを用いたタンパク質複合体構造解析の実際," 日本結晶学会誌, vol.61 巻 2 号 , pp79-80, 2019.5
藤間 祥子
[ doi:doi.org/10.5940/jcrsj.61.79 ]
"GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism," Proceedings of the National Academy of Sciences, USA, vol.115(38), pp9563-9568, 2018.9.19
Shimizu, H, Toma, S, Kontani, K, Katada, T, Shimizu, T.
[ doi:doi: 10.1073/pnas.1804740115. ]
受賞
"学術賞," 日本結晶学会 , 2024.8.15
藤間 祥子
所属学協会
日本薬学会
日本結晶学会
日本生化学会
資料

山崎 洋一

職位 助教
領域 物質創成科学領域 基幹研究室
研究室 分子複合系科学

蛋白質分子集団が示す自律的集合離散現象に注目し、蛋白質科学及び生物物理学を基礎として、創薬のターゲットとなり得る蛋白質分子複合系の理解や次世代蛋白質分子複合材料の開発に関する研究・教育を行う。

米澤 健人

職位 特任助教
領域 デジタルグリーンイノベーションセンター
研究室 デジタルグリーンイノベーション部門

上久保 裕生

職位 教授
領域 デジタルグリーンイノベーションセンター
研究室 国際連携部門