研究キーワード
自己組織化, アクチン, 再生医療, プロテオミクス, システムバイオロジー, 対称性の破れ, 極性, 軸索, 神経細胞, Polarity, Axon, Proteomics, Neuron
研究分野
ライフサイエンス / 医化学 / , ライフサイエンス / 発生生物学 / , ライフサイエンス / 医化学 / , ライフサイエンス / 発生生物学 / , ライフサイエンス / 細胞生物学 / , ライフサイエンス / 生物物理学 / , ライフサイエンス / 神経科学一般 / , ライフサイエンス / 神経科学一般 / , ライフサイエンス / 神経科学一般 /
研究室概要
神経細胞や組織の形態形成の仕組みを、シグナル伝達、細胞骨格、細胞内輸送の観点から、分子・細胞・発生生物学的手法、力計測及び数理モデルの手法を用いて統合的に解明するとともに、その破綻により引き起こされる疾患の原因解明と治療法開発を目指す研究・教育を行う。
学術論文
"Mechanical signaling through membrane tension induces somal translocation during neuronal migration ," EMBO Journal, 20 Dec. 2024
Takunori Minegishi, Honami Hasebe, Tomoya Aoyama, Keiji Naruse, Yasufumi Takahashi, Naoyuki Inagaki
[ doi:10.1038/s44318-024-00326-8 ]
"Adhesion-Clutch between DCC and Netrin-1 Mediates Netrin-1-induced Axonal Haptotaxis," Frontiers in Molecular Neuroscience, vol.17, pp1307755, 5 Feb. 2024
Zhen Qiu, Takunori Minegishi, Daichi Aoki, Kouki Abe, Kentaro Baba, Naoyuki Inagaki
"Bayesian traction force estimation using cell boundary-dependent force priors ," Biophysical Journal, 2023.11
Ryosuke Fujikawa, Chika Okimura, Satoshi Kozawa, Kazushi Ikeda, Naoyuki Inagaki, Yoshiaki Iwadate, Yuichi Sakumura
"Guided Axon Outgrowth of Neurons by Molecular Gradients Generated from Femtosecond Laser-Fabricated Micro-Holes," Talanta, Sep. 2023
Dian Anggraini, Tianlong Zhang, Xun Liu, Kazunori Okano, Yo Tanaka, Naoyuki Inagaki, Ming Li, Yoichiroh Hosokawa, Sohei Yamada
"Dephosphorylation of neural wiring protein shootin1 by PP1 phosphatase regulates netrin-1-induced axon guidance," J Biol Chem, vol.299, no.105, May 2023, pp104687, 30 Mar. 2023
Kastian R F, Baba K, Kaewkascholkul N, Sasaki H, Watanabe R, Toriyama M, Inagaki N
"Mechanical regulation of synapse formation and plasticity," Sem. Cell Dev. Biol., vol.140, no.15 May 2023, pp82-89, 17 May. 2022
Minegishi T, Kastian RF, Inagaki N
[ doi:10.1016/j.semcdb.2022.05.017 ]
"Simultaneous analyses of clutch coupling and actin polymerization in dendritic spines during chemical LTP," Star Protoc, vol.2, pp100904, Oct. 2021
Kastian RF, Minegishi T, Inagaki N
"Analyses of actin dynamics, clutch coupling and traction force for growth cone advance," J. Vis. Exp. , vol.e63227, Oct. 2021
Minegishi, T, Fujikawa, R, Kastian, R.F, Sakumura, Y, Inagaki, N
"Mechanosensitive Axon Outgrowth Mediated by L1–Laminin Clutch Interface," Biophysical Journal, vol.120, no.17, pp3566-3576, 7 Sep. 2021
Kouki Abe, Kentaro Baba, Liguo Huang, Koay Teng Wei, Kazunori Okano, Yoichiroh Hosokawa, Naoyuki Inagaki
[ doi:10.1016/j.bpj.2021.08.009 ]
"Mechanosensitive axon outgrowth mediated by L1-laminin clutch interface," Biophysical Journal, vol.120, no.17, pp3566-3576, 7 Sep. 2021
Kouki Abe, Kentaro Baba, Li guo Huang, Koay Teng Wei, Kazunori Okano, Yoichiroh Hosokawa, Naoyuki Inagaki
[ doi:10.1016/j.bpj.2021.08.009 ]
"Guided Axon Outgrowth of Neurons by Real-Time Femtosecond Laser Penetration on a 4 μm Thick Thin-Glass Sheet," bioRχiv, 2021.8.19
Dian Anggraini, Xun Liu, Kazunori Okano, Yo Tanaka, Naoyuki Inagaki, Ming Li, Yoichiroh Hosokawa, Sohei Yamada, Yaxiaer Yalikun
[ doi:10.1101/2021.08.17.456633 ]
"Shootin1a-mediated actin-adhesion coupling generates force to trigger structural plasticity of dendritic spines," Cell Reports, vol.35, no.7, pp109130, 18 May. 2021
Kastian RF, Minegishi T, Baba K, Saneyoshi T, Katsuno-Kambe H, Saranpal S, Hayashi Y, Inagaki N
"Forces to drive neuronal migration steps," Front. Cell Dev. Biol., 1 Sep. 2020
Takunori Minegishi, Naoyuki Inagaki
[ doi:10.3389/fcell.2020.00863 ]
"An artificial amphiphilic peptide promotes endocytic uptake by inducing membrane curvature," Bioconjug Chem, vol.in press, 13 May. 2020
Masuda T, Hirose H, Baba K, Walrant A, Sagan S, Inagaki N, Fujimoto T, Futaki S
"神経細胞の移動と軸索ガイダンスのメカノバイオロジー—Shootin1によるクラッチ連結が生み出す推進力の発生機構," 実験医学増刊「疾患に挑むメカノバイオロジー」, vol.38, no.7, pp113-120, 2020.4.20
嶺岸卓德, 稲垣直之
"Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system," Scientific Reports, vol.9, no.12156, 21 Aug. 2019
Urasaki A, Morishita S, Naka K, Uozumi M, Abe K, Huang L, Watase E, Nakagawa O, Kawakami K, Matsui T, Bessho Y, Inagaki N
[ NAISTレポジトリ ]
"An influenza-derived membrane tension-modulating peptide regulates cell movement and morphology via actin remodeling," Communications Biology, vol.2, no.243, pp---, 26 Jun. 2019
Masuda T, Kentaro Baba, Nomura T. Tsujita K, Murayama T, Itoh T, Takatani-Nakase T, Sokabe M, Inagaki N., Futaki S.
"Shootin1による細胞-基質間の力の発生を介した神経細胞の細胞移動,極性形成,軸索ガイダンスおよびアクチン波," 生化学, vol.91, no.2, pp159-168, 2019.4.25
稲垣直之
[ NAISTレポジトリ ]
"Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain," Scientific Reports, vol.9, no.1799, 12 Feb. 2019
Huang, L, Urasaki, A., Inagaki, N.
[ NAISTレポジトリ ]
"Shootin1b mediates a mechanical clutch to produce force for neuronal migration," Cell Reports, vol.25, no.3, pp624-639, 16 Oct. 2018
Minegishi T, Uesugi Y, Kaneko N, Yoshida W, Sawamoto K, Inagaki N
[ NAISTレポジトリ ] [ doi:10.1016/j.celrep.2018.09.068 ]
"Gradient-reading and mechano-effector machinery for netrin-1–induced axon guidance ," eLife, vol.2018,7, no.e34593, 7 Aug. 2018
Baba, K, Yoshida, W, Toriyama, M, Shimada, T, Manning, C.F, Saito, M, Kohno, K, Trimmer, J.S, Watanabe, R, Inagaki, N.
[ NAISTレポジトリ ] [ doi:10.7554/eLife.34593 ]
"Grip and slip of L1-CAM on adhesive substrates direct growth cone haptotaxis," Proc. Natl. Acad. Sci., 27 Feb. 2018
Kouki Abe, Hiroko Katsuno, Michinori Toriyama, Kentarou Baba, Tomoyuki Mori, Toshio Hakoshima, Yonehiro Kanemura, Rikiya Watanabe, Naoyuki Inagaki
[ NAISTレポジトリ ] [ doi:10.1073/pnas.1711667115 ]
"Actin Waves: Origin of Cell Polarization and Migration?," Trends in Cell Biology , vol.27, no.7, pp515-526, Mar. 2017
Naoyuki Inagaki, Hiroko Katsuno
[ NAISTレポジトリ ] [ doi:10.1016/j.tcb.2017.02.003 ]
"Identification of a shootin1 isoform expressed in peripheral tissues," Cell Tissue Res., vol.366(1), pp75-87, Apr. 2016
Yasuna Higashiguchi, Kazuhiro Katsuta, Takunori Minegishi, Shigenobu Yonemura, Akihiro Urasaki, Naoyuki Inagaki
[ NAISTレポジトリ ] [ doi:10.1007/s00441-016-2415-9 ]
"神経細胞極性," 脳科学辞典(林康紀 他編), 2016.3.17
勝野弘子, 稲垣 直之
[ doi:10.14931/bsd.7001 ]
"Shootin1–cortactin interaction mediates signal–force transduction for axon outgrowth," The Journal of Cell Biology, vol.210, no.4, pp663-676, 17 Aug. 2015
Yusuke Kubo, Kentarou Baba, Michinori Toriyama, Takunori Minegishi, Tadao Sugiura, Satoshi Kozawa, Kazushi Ikeda, Naoyuki Inagaki
[ NAISTレポジトリ ]
"Efficient Solid-Phase Gene Delivery Mediated by Cerasome: Effect of Reverse Procedure on Transfection Performances in Comparison with Solution-Based Method," Chem. Lett., Aug. 2015
K. Tahara, M. Tsukui, T. Maeno, N. Inagaki, J. Kikuchi
"Actin migration driven by directional assembly and disassembly of membrane anchored actin filaments," Cell Reports, vol.12, pp648-660, 16 Jul. 2015
Katsuno, H, Toriyama, M, Yoichiroh Hosokawa, Mizuno, K, Kazushi Ikeda, Sakumura, Y,, Inagaki, N.
[ NAISTレポジトリ ]
"Bayesian cell force estimation considering force directions," Neural Processing Letters, vol.41, no.2, pp191-200, Apr. 2015
Satoshi Kozawa, Yuichi Sakumura, Toriyama,M., Naoyuki Inagaki, Kazushi Ikeda
[ doi:10.1007/s11063-013-9320-y ]
"離合集散が織りなす生命分子機能 の研究フロンティア、実験医学 33, 1316-1320.," 実験医学, vol.33, pp1316-1320, 2015.2
加藤晃一, 稲垣直之
"ラージゲルプロテオミクスを基盤とした神経細胞の軸索形成とガイダンスの解析," 電気泳動, vol.第58巻, no.第2号, pp49-52, 2014.10
馬場健太郎, 浦崎明宏, 稲垣直之
[ NAISTレポジトリ ] [ doi:10.2198/sbk.58.49 ]
"Ceramic Coating of Liposomal Gene Carrier for Minimizing Toxicity to Primary Hippocampal Neurons," Chem. Lett., vol.42, pp1265-1267, 5 Oct. 2013
Keishiro Tahara, Moriuchi, Takanobu, Tsukui, Miku, Hirota, Akira, Maeno, Takanori, Toriyama, Michinori, Naoyuki Inagaki, Junichi Kikuchi
"Bayesian Cell Force Estimation Considering Force Directions," Sep. 2013
Satoshi Kozawa, Yuichi Sakumura, Michinori Toriyama, Naoyuki Inagaki, Kazushi Ikeda
"Ceramic coating of liposomal gene carrier for minimizing toxicity to promary hippocampal neurons," Chemistry Letters, vol.42, pp1265-1267, 20 Jul. 2013
Keishiro Tahara, Moriuchi,T., Tsukui,M., Hirota,A., Maeno,T., Toriyama,M., Naoyuki Inagaki, Junichi Kikuchi
[ doi:10.1246/cl.130541 ]
"Conversion of a signal into forces for axon outgrowth through Pak1-mediated shootin1 phosphorylation," Curr. Biol, vol.23, pp529-534, 18 Mar. 2013
Toriyama M, Kozawa S, Sakumura Y., Inagaki, N.
[ NAISTレポジトリ ] [ doi:10.1016/j.cub.2013.02.017 ]
"CRMP2," 脳科学辞典(田中啓治, 御子柴克彦編), 2012.10.26
久保祐亮, 稲垣 直之
[ NAISTレポジトリ ] [ doi:10.14931/bsd.2286 ]
"Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth.," J Neurosci., vol.32, no.37, pp12712-12725, Sep. 2012
Nakazawa H, Sada T, Toriyama M, Tago K, Sugiura T, Fukuda M, Inagaki N.
[ NAISTレポジトリ ] [ doi:10.1523/JNEUROSCI.0989-12.2012 ]
"プロテオミクスを基礎にした神経細胞が非対称性を獲得する機構の解析," 生物物理化学, vol.56, no.1, pp31-34, 2012.4
吉田亙, 鳥山道則, 稲垣直之
[ doi:10.2198/sbk.56.31 ]
"Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain," EMBO J., vol.30, no.13, pp2734-2747, Jun. 2011
Hirano Y, Hatano T, Takahashi A, Toriyama M, Inagaki N, Hakoshima T.
[ doi:10.1038/emboj.2011.177 ]
"Systems Biology of Symmetry-Breaking during Neuronal Polarity Formation," Dev. Neurobiol, vol.71, no.6, pp584-593, Jun. 2011
Inagaki N, Toriyama M, Sakumura Y
[ NAISTレポジトリ ] [ doi:10.1002/dneu.20837 ]
"Dynamic changes in the leaf proteome of a C3 xerophyte, Citrullus lanatus (wild watermelon), in response to water deficit.," Planta, vol.233, pp947, May. 2011
明石 欣也, 吉田 和生, 桑野 昌義, 梶川 昌孝, 吉村 和也, 星安 紗希, 稲垣 直之, 横田 明穂
[ doi:10.1007/s00425-010-1341-4 ]
"神経細胞が軸索の長さを検知する仕組みと神経細胞の対称性の破れ," 遺伝, vol.65, pp80-86, 2011.5
鳥山道則, 作村諭一, 稲垣直之
"Dynamic changes in the leaf proteome of a C3 xerophyte, Citrullus lanatus (wild watermelon), in response to water deficit.," Planta, vol.in print, Jan. 2011
Akashi, K, Yoshida, K, Kuwano, M, Kajikawa, M, Yoshimura, K, Hoshiyasu, S, Inagaki, N, Yokota, A.
[ doi:10.1007/s00425-010-1341-4 ]
"A diffusion-based neurite length sensing mechanism involved in neuronal symmetry-breaking," Mol. Sys. Biol., vol.6, pp394, Jul. 2010
Toriyama, M, Sakumura, Y, Shimada, T, Ishii, S., Inagaki, N.
[ NAISTレポジトリ ] [ doi:10.1038/msb.2010.51 ]
"Proteomics analysis of temporal changes in axonal proteins during maturation," Dev. Neurobiol., vol.70, pp523-537, Jun. 2010
Yamatani, H, Kawasaki, T, Mita, S, Inagaki, N, Hirata, T
[ doi:10.1002/dneu.20794 ]
"ニューロンにはアクソンは1本しかないのか?," Clinical Neuroscience, vol.28, no.1月, pp113, 2010.1
鳥山 道則, 稲垣 直之
"Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth.," J. Cell Biol., vol.181, no.5, pp817-829, 2 Jun. 2008
Shimada, T, Toriyama, M, Uemura, K, Kamiguchi, H, Sugiura, T, Watanabe, N., Inagaki, N.
[ NAISTレポジトリ ] [ doi:10.1083/jcb.200712138 ]
"Singar1, a Novel RUN Domain-containing Protein, Suppresses Formation of Surplus Axons for Neuronal Polarity.," J Biol Chem, vol.282, no.27, pp19884, Jul. 2007
Mori, T, Wada, T, Suzuki, T, Kubota, Y., Inagaki, N.
[ NAISTレポジトリ ] [ doi:10.1074/jbc.M700770200 ]
"Shootin1: a protein involved in the organization of an asymmetric signal for neuronal polarization.," J. Cell Biol., vol.175, pp147-157, Oct. 2006
Toriyama. M, Shimada. T, Kim. K-B, Mitsuba. M, Nomura. E, Katsuta. K, Sakumura. Y, Roepstorff. P, Inagaki. N.
[ NAISTレポジトリ ] [ doi:10.1083/jcb.200604160 ]
"Large Gel Two-Dimensional Electrophoresis: Improving Recovery of Cellular Proteome," Current Proteomics, vol.1, no.1, pp35-39, Jan. 2004
Naoyuki Inagaki, Kazuhiro Katsuta
[ NAISTレポジトリ ]
"CRMP-2 induces axons in cultured hippocampal neurons. ," Nat Neurosci, vol.4, no.8, pp781-782, Aug. 2001
Inagaki, N, Chihara, K, Arimura, N, Menager, C, Kawano, Y, Matsuo, N, Nishimura, T, Amano, M, Kaibuchi, K.
受賞
所属学協会
The American Society for Cell Biology
日本分子生物学会
米国神経科学会
日本薬理学会
日本神経科学会
日本癌学会
日本生化学会
日本細胞生物学会
資料

馬場 健太郎

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 神経システム生物学

神経細胞や組織の形態形成の仕組みを、シグナル伝達、細胞骨格、細胞内輸送の観点から、分子・細胞・発生生物学的手法、力計測及び数理モデルの手法を用いて統合的に解明するとともに、その破綻により引き起こされる疾患の原因解明と治療法開発を目指す研究・教育を行う。

嶺岸 卓德

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 神経システム生物学

神経細胞や組織の形態形成の仕組みを、シグナル伝達、細胞骨格、細胞内輸送の観点から、分子・細胞・発生生物学的手法、力計測及び数理モデルの手法を用いて統合的に解明するとともに、その破綻により引き起こされる疾患の原因解明と治療法開発を目指す研究・教育を行う。