研究キーワード
Saccharomyces cerevisiae, 代謝, 醸造, 発酵, 清酒酵母, アルコール発酵, 酵母
研究分野
ライフサイエンス / 応用分子細胞生物学 / , ライフサイエンス / 応用微生物学 /
研究室概要
微生物が進化の過程で獲得した様々な「環境ストレス」に対する適応機構について、分子・代謝・細胞レベルで解明し、多様な微生物機能を理解するとともに、微生物育種・物質生産などの技術開発を通して、バイオテクノロジーへの貢献を目指した研究・教育を行う。
学術論文
"植物クチクラ層に微生物生態系は成立するのか," アグリバイオ, vol.8, no.8, pp50-52, 2024.7.31
渡辺大輔
"伝統的発酵食品の生態系を形づくる微生物間相互作用," 日本醸造協会誌, vol.119, no.7, pp338-346, 2024.7.15
吉岡求, 渡辺大輔
"Sake yeast symbiosis with lactic acid bacteria and alcoholic fermentation," Biosci Biotechnol Biochem, vol.88, no.3, pp237-241, 21 Feb. 2024
Daisuke Watanabe
[ doi:10.1093/bbb/zbad167 ]
"酵母は細胞壁の厚さを調節してアルコール発酵力を制御する," バイオサイエンスとインダストリー, vol.82, no.2, pp156-157, 2024.2.10
渡辺大輔
"クラウドファンディングという体験," バイオサイエンスとインダストリー, vol.82, no.2, pp173-173, 2024.2.10
渡辺大輔
"Spontaneous Attenuation of Alcoholic Fermentation via the Dysfunction of Cyc8p in Saccharomyces cerevisiae," Int. J. Mol. Sci., vol.25, pp304, 25 Dec. 2023
Daisuke Watanabe, Maika Kumano, Yukiko Sugimoto, Hiroshi Takagi
"伝統的発酵食品における酵母のふるまいを追究する," 生物工学会誌, 2023.10
渡辺大輔
"清酒酵母の共生とアルコール発酵," 温古知新, vol.60, pp67-72, 2023.8
渡辺大輔
"Crystal structures of Lacticaseibacillus 4-deoxy-L-threo-5-hexosuloseuronate ketol-isomerase KduI in complex with substrate analogs," Journal of Applied Glycoscience, 26 Jul. 2023
Hisamu Iwase, Yuta Yamamoto, Akifumi Yamada, Keigo Kawai, Sayoko Oiki, Daisuke Watanabe, Bunzo Mikami, Ryuichi Takase, Wataru Hashimoto
[ doi:10.5458/jag.jag.JAG-2023_0003 ]
"Rational design of alcoholic fermentation targeting extracellular carbon," NPJ Science of Food, vol.7, pp37, 21 Jul. 2023
Daisuke Watanabe, Mikiya Kawashima, Naoya Yoshioka, Yukiko Sugimoto, Hiroshi Takagi
[ NAISTレポジトリ ]
"Adaptation of yeast Saccharomyces cerevisiae to grape-skin environment," Scientific Reports, vol.13, no.1, pp9279, 20 Jun. 2023
Daisuke Watanabe, Wataru Hashimoto
[ doi:10.1038/s41598-023-35734-z ]
"Substrate size-dependent conformational changes of bacterial pectin-binding protein crucial for chemotaxis and assimilation," Sci. Rep., vol.12, no.1, pp12653, 25 Jul. 2022
K. Anamizu, R. Takase, M. Hio, D. Watanabe, B. Mikami, W. Hashimoto
"Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan," Sci. Rep., vol.12, no.1, pp10948, 29 Jun. 2022
S. Yabuuchi, S. Oiki, S. Minami, R. Takase, D. Watanabe, W. Hashimoto
"Crystal structures of EfeB and EfeO in a bacterial siderophore-independent iron transport system," Biochem. Biophys. Res. Commun., vol.594, pp124-130, 26 Feb. 2022
S. Nakatsuji, K. Okumura, R. Takase, D. Watanabe, B. Mikami, W. Hashimoto
"Accelerated alcoholic fermentation of intact grapes by Saccharomyces cerevisiae in symbiosis with microbial community inhabiting grape-skin," Res. Sq., 23 Sep. 2021
D. Watanabe, W. Hashimoto
"Genome editing to generate sake yeast strains with eight mutations that confer excellent brewing characteristics," Cells, vol.10, no.6, pp1299, 24 May. 2021
T. Chadani, S. Ohnuki, A. Isogai, T. Goshima, M. Kashima, F. Ghanegolmohammadi, T. Nishi, D. Hirata, D. Watanabe, K. Kitamoto, T. Akao, Y. Ohya
"Isolation of novel alcohol-tolerant spontaneous mutant strains from sake yeast Kyokai no. 6 and no. 7, and their brewing characteristics," J. Brew. Soc. Japan, vol.116, no.2, pp111-124, 15 Feb. 2021
T. Murakami, M. Watanabe, M. Takaki, H. Suetsugu-Sasaki, D. Watanabe, T. Goshima, H. Fukuda, H. Shimoi, T. Akao
"Bacterial inducible expression of plant cell wall-binding protein YesO through conflict between Glycine max and saprophytic Bacillus subtilis," Sci. Rep., vol.10, no.1, pp18691, 29 Oct. 2020
H. Sugiura, A. Nagase, S. Oiki, B. Mikami, D. Watanabe, W. Hashimoto
"The C2 domain of the ubiquitin ligase Rsp5 is required for ubiquitination of the endocytic protein Rvs167 upon change of nitrogen source.," FEMS Yeast Res., vol.20, ppfoaa058, 14 Oct. 2020
Ryoya Tanahashi, Tira Siti Nur Afiah, Akira Nishimura, Daisuke Watanabe, Hiroshi Takagi
[ doi:10.1093/femsyr/foaa058 ]
"Mutually beneficial symbiosis between human and gut-dominant Bacteroides species through bacterial assimilation of host mucosubstances," bioRxiv, 22 Aug. 2020
M. Sato, K. Kajikawa, T. Kumon, D. Watanabe, R. Takase, W. Hashimoto
"Polyunsaturated fatty acids-enriched lipid from reduced sugar alcohol mannitol by marine yeast Rhodosporidiobolus fluvialis Y2," Biochem. Biophys. Res. Commun., vol.526, no.4, pp1138-1142, 18 Apr. 2020
S. Nakata, M. Hio, R. Takase, S. Kawai, D. Watanabe, W. Hashimoto
"酵母は何を感知してアルコール発酵を調節しているのか?," 生物工学会誌, vol.98, no.4, pp170-173, 2020.4
渡辺大輔, 高木博史
"The sake yeast YHR032W/ERC1 allele contributes to the regulation of the tetrahydrofolate content in the folate synthetic pathway in sake yeast strains," Biosci. Biotechnol. Biochem., vol.84, no.5, pp1073-1076, 21 Jan. 2020
M. Kanai, T. Kawata, T. Morimoto, M. Mizunuma, D. Watanabe, T. Akao, T. Fujii, H. Iefuji
"Effect of the deubiquitination enzyme gene UBP6 on the stress-responsive transcription factor Msn2-mediated control of the amino acid permease Gnp1 in yeast.," J. Biosci. Bioeng., no.129, pp423-427, Jan. 2020
Noreen Suliani binti Mat Nanyan, Daisuke Watanabe, Yukiko Sugimoto, Hiroshi Takagi
[ doi:10.1016/j.jbiosc.2019.10.002. ]
"Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae.," Microbial Cell, vol.6, pp482-490, Oct. 2019
Y. Mukai, Y. Kamei, X. Liu, S. Jiang, Y. Sugimoto, Noreen Suliani binti Mat Nanyan, D. Watanabe, H. Takagi
"Yeast prion-based metabolic reprogramming induced by bacteria in fermented foods.," FEMS Yeast Res., vol.19, ppfoz061, Aug. 2019
D. Watanabe, H. Takagi
[ doi:10.1093/femsyr/foz061 ]
"Characterization of a new Saccharomyces cerevisiae isolated from hibiscus flower and its mutant with l-leucine accumulation for awamori brewing.," Front. Genet., no.10, pp490, May. 2019
T. Abe, Y. Toyokawa, Y. Sugimoto, H. Azuma, K. Tsukahara, R. Nasuno, D. Watanabe, M. Tsukahara, H. Takagi
[ doi:10.3389/fgene.2019.00490. ]
"Stable N-acetyltransferase Mpr1 improves ethanol productivity in the sake yeast Saccharomyces cerevisiae.," J. Ind. Microbiol. Biotechnol., no.46, pp1039-1045, Apr. 2019
M. Ohashi, R. Nasuno, D. Watanabe, H. Takagi
"Meiotic chromosomal recombination defect in sake yeasts," J. Biosci. Bioeng., vol.127, no.2, pp190-196, 2 Feb. 2019
H. Shimoi, Y. Hanazumi, N. Kawamura, M. Yamada, S. Shimizu, T. Suzuki, D. Watanabe, T. Akao
"Involvement of the stress-responsive transcription factor gene MSN2 in the control of amino acid uptake in Saccharomyces cerevisiae.," FEMS Yeast Res., no.19, ppfoz052, Jan. 2019
Noreen Suliani binti Mat Nanyan, D. Watanabe, Y. Sugimoto, H. Takagi
"Loss of Rim15p in shochu yeast alters carbon utilization during barley shochu fermentation.," Biosci. Biotech. Biochem, no.83, pp1594-1597, 2019
D. Watanabe, S. Tashiro, D. Shintani, Y. Sugimoto, A. Iwami, Y. Kajiwara, H. Takashita, H. Takagi
"Nutrient Signaling via the TORC1-Greatwall-PP2AB55δ Pathway Responsible for the High Initial Rates of Alcoholic Fermentation in Sake Yeast Strains of Saccharomyces cerevisiae," Applied and Environmental Microbilogy, 19 Oct. 2018
Daisuke Watanabe, Takuma Kajihara, Yukiko Sugimoto, Kenichi Takagi, Megumi Mizuno, Yan Zhou, Jiawen Chen, Kojiro Takeda, Hisashi Tatebe, Kazuhiro Shiozaki, Nobushige Nakazawa, Shingo Izawa, Takeshi Akao, Hitoshi Shimoi, Tatsuya Maeda, Hiroshi Takagi
[ NAISTレポジトリ ] [ doi:10.1128/AEM.02083-18 ]
"Importance of Proteasome Gene Expression during Model Dough Fermentation after Freezing Preservation of Baker’s Yeast Cells," Applied and Environmental Microbiology, vol.83, no.12, Apr. 2018
Daisuke Watanabe, Hiroshi Sekiguchi, Yukiko Sugimoto, Atsushi Nagasawa, Naotaka Kida, Hiroshi Takagi
[ NAISTレポジトリ ] [ doi:10.1128/AEM.00406-18 ]
"Valine biosynthesis in Saccharomyces cerevisiae is regulated by the mitochondrial branched-chain amino acid aminotransferase Bat1.," Microb Cell., vol.21;5, no.6, pp293-299, Mar. 2018
Natthaporn Takpho, Daisuke Watanabe, Hiroshi Takagi
"High-level production of valine by expression of the feedback inhibition-insensitive acetohydroxyacid synthase in Saccharomyces cerevisiae.," Metab Eng. , vol.46, pp60-67, Mar. 2018
Natthaporn Takpho, Daisuke Watanabe, Hiroshi Takagi
"High-level production of valine by expression of the feedback inhibition-insensitive acetohydroxyacid synthase in Saccharomyces cerevisiae," Metabolic Engineering, vol.46, pp60-67, Feb. 2018
Natthaporn Takpho, Daisuke Watanabe, Hiroshi Takagi
[ NAISTレポジトリ ] [ doi:10.1016/j.ymben.2018.02.011 ]
"Metabolic switching of sake yeast by kimoto lactic acid bacteria through the [GAR+] non-genetic element.," J. Biosci. Bioeng, no.126, pp624-629, 2018
D. Watanabe, M. Kumano, Y. Sugimoto, M. Ito, M. Ohashi, K. Sunada, T. Takahashi, T. Yamada, H. Takagi
"Accumulation of intracellular S-adenosylmethionine increases the fermentation rate of bottom-fermenting brewer's yeast during high-gravity brewing.," J. Biosci. Bioeng, no.126, pp736-741, 2018
M. Oomuro, D. Watanabe, Y. Sugimoto, T. Kato, Y. Motoyama, T. Watanabe, H. Takagi
"Sodium acetate responses in Saccharomyces cerevisiae and the ubiquitin ligase Rsp5.," Front. Microbiol., vol.9, pp2495, 2018
A. Watcharawipas, D. Watanabe, H. Takagi
"酵母ユビキチンリガーゼRsp5による選択的な基質認識とその応用への可能性 ユビキチンの「誤送信」を防ぐ," 化学と生物, vol.57, pp36-42, 2018
渡辺大輔, 高木博史
"Enhanced sodium acetate tolerance in Saccharomyces cerevisiae by the Thr255Ala mutation of the ubiquitin ligase Rsp5," FEMS Yeast Res., vol.17, no.8, 1 Dec. 2017
Akaraphol Watcharawipas, Daisuke Watanabe, Hiroshi Takagi
[ doi:10.1093/femsyr/fox083 ]
"Phenotypic diagnosis of lineage and differentiation during sake yeast breeding.," G3 (Bethesda)., Jul. 2017
Shinsuke Ohnuki, Hiroki Okada, Anne Friedrich, Yoichiro Kanno, Tetsuya Goshima, Hirokazu Hasuda, Masaaki Inahashi, Naoto Okazaki, Hiroyasu Tamura, Ryo Nakamura, Dai Hirata, Hisashi Fukuda, Hitoshi Shimoi, Katsuhiko Kitamoto, Daisuke Watanabe, Joseph Schacherer, Takeshi Akao, Yoshikazu Ohya
[ doi:10.1534/g3.117.044099 ]
"Pleiotropic functions of the yeast Greatwall-family protein kinase Rim15p: a novel target for the control of alcoholic fermentation.," Biosci. Biotech. Biochem., vol.81, no.6, pp1061-1068, Jun. 2017
Daisuke Watanabe, Hiroshi Takagi
[ doi:10.1080/09168451.2017.1295805 ]
"お酒をつくる酵母 ―― ゲノムから解き明かす醸造特性のひみつ.," 生物の科学 遺伝「発酵・醸造食品における多様な微生物の働き」, vol.71, no.3, pp206-212, 2017.5
渡辺 大輔, 高木 博史
"Promoter engineering of the Saccharomyces cerevisiae RIM15 gene for improvement of alcoholic fermentation rates under stress conditions.," J. Biosci. Bioeng., vol.123, no.2, pp183-189, Feb. 2017
Daisuke Watanabe, Akie Kaneko, Yukiko Sugimoto, Takahiro Negishi, Shinsuke Ohnuki, Hiroshi Takagi, Yoshikazu Ohya
[ doi:10.1016/j.jbiosc.2016.08.004 ]
"Yeasts for Global Happiness: report of the 14th International Congress on Yeasts (ICY14) held in Awaji Island. ," Gene Cells, vol.22, no.2, pp130-134, 20 Jan. 2017
Daisuke Watanabe, Hiroshi Takagi
[ doi:10.1111/gtc.12471 ]
"Sake yeast YHR032W/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains.," J. Biosci. Bioeng., vol.123, no.1, pp8-14, Jan. 2017
Muneyoshi Kanai, Tomoko Kawata, Yoshie Yoshida, Yasuko Kita, Takafumi Ogawa, Masaki Mizunuma, Daisuke Watanabe, Hitoshi Shimoi, Akihiro Mizuno, Osamu Yamada, Tsutomu Fujii, Haruyuki Iefuji
[ doi:10.1016/j.jbiosc.2016.07.007 ]
"Defective quiescence entry promotes the fermentation performance of bottom-fermenting brewer's yeast. ," J. Biosci. Bioeng, vol.122, no.5, pp577-582, Nov. 2016
Mayu Oomuro, Taku Kato, Yan Zhou, Daisuke Watanabe, Yasuo Motoyama, Hiromi Yamagishi, Takeshi Akao, Masayuki Aizawa
[ doi:10.1016/j.jbiosc.2016.04.007 ]
"Isolation of baker’s yeast mutants with proline accumulation that showed enhanced tolerance to baking-associated stresses.," Int. J. Food Microbiol., vol.238, pp233-240, 22 Sep. 2016
Ariunzaya Tsolmonbaatar, Keisuke Hashida, Yukiko Sugimoto, Daisuke Watanabe, Shuhei Furukawa, Hiroshi Takagi
[ doi:10.1016/j.ijfoodmicro ]
"γ-Glutamyl kinase is involved in selective autophagy of ribosomes in Saccharomyces cerevisiae.," FEBS Lett., vol.590, no.17, pp2906-2914, Sep. 2016
Yuki Tatehashi, Daisuke Watanabe, Hiroshi Takagi
[ doi:10.1002/1873-3468.12318 ]
"Putative mitochondrial α-ketoglutarate-dependent dioxygenase Fmp12 controls utilization of proline as an energy source in Saccharomyces cerevisiae. ," Microbial Cell, vol.3, pp391-397, Sep. 2016
Ikuhisa Nishida, Daisuke Watanabe, Hiroshi Takagi
[ NAISTレポジトリ ]
"Regulatory mechanism of the flavoprotein Tah18-dependent nitric oxide synthesis and cell death in yeast.," Nitric Oxide-Biol. Chem., vol.57, pp85-91, 1 Jul. 2016
Yuki Yoshikawa, 那須野 亮, Nobuhiro Kawahara, Akira Nishimura, Daisuke Watanabe, Hiroshi Takagi
"Vacuolar amino acid transporters upregulated by exogenous proline and involved in cellular localization of proline in Saccharomyces cerevisiae. *These authors contributed equally to this work.," J. Gen. Appl. Microbiol., Jul. 2016
Ikuhisa Nishida, Daisuke Watanabe, Ariunzaya Tsolmonbaatar, Tomohiro Kaino, Iwao Ohtsu, Hiroshi Takagi
[ doi:10.2323/jgam.2016.01.005 ]
"Structure-based molecular design for thermostabilization of N-acetyltransferase Mpr1 involved in a novel pathway of L-arginine synthesis in yeast. ," J. Biochem., vol.159, no.2, pp271-277, Feb. 2016
R. Nasuno, S. Hirase, S. Norifune, D. Watanabe, H. Takagi
[ doi:10.1093/jb/mvv101 ]
"Nitric oxide signaling and its role in oxidative stress response in Schizosaccharomyces pombe.," Nitric Oxide-Biol. Chem., vol.30, no.52, pp29-40, Jan. 2016
R. I. Astuti, D. Watanabe, H. Takagi
[ doi:10.1016/j.niox.2015.11.001 ]
"Structure-based molecular design for thermostabilization of N-acetyltransferase Mpr1 involved in a novel pathway of L-arginine synthesis in yeast.," J. Biochem., no.159, pp271-277, 2016
R. Nasuno, S. Hirase, S. Norifune, D. Watanabe, H. Takagi
"Inhibitory role of Greatwall-like protein kinase Rim15p in alcoholic fermentation via upregulating the UDP-glucose synthesis pathway in Saccharomyces cerevisiae.," Appl. Environ. Microbiol., no.82, pp340-351, 2016
D. Watanabe, Y. Zhou, A. Hirata, Y. Sugimoto, K. Takagi, T. Akao, Y. Ohya, H. Takagi, H. Shimoi
"Vacuolar amino acid transporters upregulated by exogenous proline and involved in cellular localization of proline in Saccharomyces cerevisiae.," J. Gen. Appl. Microbiol., no.62, pp132-139, 2016
I. Nishida, D. Watanabe, A. Tsolmonbaatar, T. Kaino, I. Ohtsu, H. Takagi
"g-Glutamyl kinase is involved in selective autophagy of ribosomes in Saccharomyces cerevisiae.," FEBS Lett., no.590, pp2906-2914, 2016
Y. Tatehashi, D. Watanabe, H. Takagi
"ここまでわかった!きょうかい酵母(清酒用)の高発酵力を生み出すRIM15変異遺伝子," 日本醸造協会誌, vol.111, pp638-647, 2016
渡辺大輔, 高木博史
"Inhibitory role of Greatwall-like protein kinase Rim15p in alcoholic fermentation via upregulating the UDP-glucose synthesis pathway in Saccharomyces cerevisiae.," Appl. Environ. Microbiol., vol.82, no.1, pp340-351, 23 Oct. 2015
D. Watanabe, Y. Zhou, A. Hirata, Y. Sugimoto, K. Takagi, T. Akao, Y. Ohya, H. Takagi
[ doi:10.1128/AEM.02977-15 ]
"Cooperative and selective roles of the WW domains of the yeast Nedd4-like ubiquitin ligase Rsp5 in the recognition of the arrestin-like adaptors Bul1 and Bul2.," Biochem. Biophys. Res. Commun., vol.463, no.1-2, pp76-81, Jul. 2015
D. Watanabe, H. Murai, R. Tanahashi, K. Nakamura, T. Sasaki, H. Takagi
[ doi:10.1016/j.bbrc.2015.05.025 ]
"A finding of thiosulfate pathway for synthesis of organic sulfur compounds in Saccharomyces cerevisiae and an improvement of ethanol production. ," J. Biosci. Bioeng., vol.120, pp666-669, Apr. 2015
E. Funahashi*, K. Saiki*, K. Honda, Y. Sugiura, Y. Kawano, I. Ohtsu, D. Watanabe, Y. Wakabayashi, T. Abe, T. Nakanishi, M. Suematsu, H. Takagi
[ doi:10.1016/j.jbiosc ]
"Isolation and characterization of awamori yeast mutants with l-leucine accumulation that overproduce isoamyl alcohol.," J. Biosci. Bioeng., no.119, pp140-147, 2015
H. Takagi, K. Hashida, D. Watanabe, R. Nasuno, M. Ohashi, T. Iha, M. Nezuo, M. Tsukahara
"Isolation and functional analysis of yeast ubiquitin ligase Rsp5 variants that alleviate the toxicity of human a-synuclein.," J. Biochem., no.157, pp251-260, 2015
I. Wijayanti, D. Watanabe, S. Oshiro, H. Takagi
"Awa1p on the cell surface of sake yeast inhibits biofilm formation and the co-aggregation between sake yeasts and Lactobacillus plantarum ML11-11.," J. Biosci. Bioeng., no.119, pp532-537, 2015
S. Hirayama, M. Shimizu, N. Tsuchiya, S. Furukawa, D. Watanabe, H. Shimoi, H. Takagi, H. Ogihara, Y. Morinaga
"Finding of thiosulfate pathway for synthesis of organic sulfur compounds in Saccharomyces cerevisiae and improvement of ethanol production.," J. Biosci. Bioeng., no.120, pp666-669, 2015
E. Funahashi, K. Saiki, K. Honda, Y. Sugiura, Y. Kawano, I. Ohtsu, D. Watanabe, Y. Wakabayashi, T. Abe, T. Nakanishi, M. Suematsu, H. Takagi
"酵母のエタノール耐性 内と外から細胞を護る," 生物工学会誌, vol.93, pp460-463, 2015
渡辺大輔, 高木博史
"Isolation and functional analysis of yeast ubiquitin ligase Rsp5 variants that alleviate the toxicity of human α-synuclein. ," J. Biochem, Nov. 2014
I. Wijayanti*, Daisuke Watanabe, S. Oshiro, H. Takagi
[ doi:10.1093/jb/mvu069 ]
"Awa1p on the cell surface of sake yeast inhibits biofilm formation and the co-aggregation between sake yeasts and Lactobacillus plantarum ML11-11.," J. Biosci. Bioeng., Nov. 2014
S. Hirayama, M. Shimizu, N. Tsuchiya, S. Furukawa, D. Watanabe, H. Shimoi, H. Takagi, H. Ogihara, Y. Morinaga
[ doi:10.1016/j.jbiosc.2014.10.007 ]
"Quality control of plasma membrane proteins by yeast Nedd4-like ubiquitin ligase Rsp5p under environmental stress conditions. ," Eukaryot. Cell, vol.13, no.9, pp1191-1199, Sep. 2014
T. Shiga, N. Yoshida, Y. Shimizu, E. Suzuki, T. Sasaki, D. Watanabe, H. Takagi
"出芽酵母におけるメタカスパーゼを介した寿命延長," 細胞工学, vol.33, no.8, 2014.8
渡辺 大輔
"Isolation and characterization of awamori yeast mutants with L-leucine accumulation that overproduce isoamyl alcohol. ," J. Biosci. Bioeng., Jul. 2014
H. Takagi, K. Hashida, D. Watanabe, R. Nasuno, M. Ohashi, T. Iha, M. Nezuo, M. Tsukahara
[ doi:10.1016/j.jbiosc.2014.06.020 ]
"Exogenous addition of histidine reduces copper availability in the yeast Saccharomyces cerevisiae. ," Microbial Cell, vol.1, no.7, pp241-246, Jul. 2014
D. Watanabe, R. Kikushima, M. Aitoku, A. Nishimura, I. Ohtsu, Ryo Nasuno, H. Takagi
[ NAISTレポジトリ ]
"1細胞ゲノム解析で明らかになったピコプランクトンの集団構造," 細胞工学, vol.33, no.7, 2014.7
渡辺 大輔
"大腸菌におけるスルホキノボース解糖経路の発見," 細胞工学, vol.33, no.6, 2014.6
渡辺 大輔
"酵母の生活環に関する収斂進化のメカニズム," 細胞工学, vol.33, no.5, 2014.5
渡辺 大輔
"ストレスによって「硬直」するバクテリアたち," 細胞工学, vol.33, no.4, 2014.4
渡辺 大輔
"Calcineurin inhibitors suppress the high-temperature stress sensitivity of the yeast ubiquitin ligase Rsp5 mutant: A new method of screening for calcineurin inhibitors," FEMS Yeast Res., vol.14, pp567-574, 6 Mar. 2014
S. Uesugi, Daisuke Watanabe, M. Kitajima, R. Watanabe, Y. Kawamura, M. Ohnishi, Hiroshi Takagi, K. Kimura
[ doi:10.1111/1567-1364.12143 ]
"不要な遺伝子にサヨナラ!! ," 日本乳酸菌学会誌, vol.25, no.1, pp41, 2014.3
渡辺 大輔
"酵母の「失恋の記憶」," 細胞工学, vol.33, no.3, 2014.3
渡辺 大輔
"遺伝子ノックアウトの表現型,どこまで信用できる?," 細胞工学, vol.33, no.2, 2014.2
渡辺 大輔
"ガソリンを作り出す微生物," 細胞工学, vol.33, no.1, 2014.1
渡辺 大輔
"An organic acid-tolerant HAA1-overexpression mutant of an industrial bioethanol strain of Saccharomyces cerevisiae and its application to the production of bioethanol from sugarcane molasses," AMB Express, vol.3, no.74, 30 Dec. 2013
Hiroshi Takagi, Daisuke Watanabe, T. Inaba, Y. Yoshiyama, K. Tanaka, J. Ogawa, H. Shimoi, J. Shima
[ NAISTレポジトリ ] [ doi:10.1186/2191-0855-3-74 ]
"進化中の酵母集団において発見された遺伝子ヒッチハイクとクローン干渉," 細胞工学, vol.32, no.12, 2013.12
渡辺 大輔
"Rim15p-mediated regulation of sucrose utilization during molasses fermentation using Saccharomyces cerevisiae strain PE-2.," J Biosci Bioeng. , vol.116, pp591-594, Nov. 2013
Hiroshi Takagi, Daisuke Watanabe, I. Inai, Y. Zhou, R. Fukada, T. Akao, J. Shima, H. Shimoi
[ doi:10.1016/j.jbiosc.2013.05.015 ]
"Accelerated alcoholic fermentation caused by defective gene expression related to glucose derepression in Saccharomyces cerevisiae," Biosci. Biotechnol. Biochem., vol.77, no.11, pp2255-2262, Nov. 2013
Daisuke Watanabe
"含硫アミノ酸による酵母の緻密な増殖制御メカニズム," 細胞工学, vol.32, no.11, 2013.11
渡辺 大輔
"Involvement of methionine salvage pathway genes of Saccharomyces cerevisiae in the production of precursor compounds of dimethyl trisulfide (DMTS) ," J. Biosci. Bioeng., vol.116, no.4, pp475-479, Oct. 2013
Daisuke Watanabe
[ doi:10.1016/j.jbiosc.2013.04.016 ]
"構造システム生物学の手法を用いた大腸菌代謝システムの熱耐性評価," 細胞工学, vol.32, no.10, 2013.10
渡辺 大輔
"TORシグナルの活性化はM期サイクリンのmRNA安定化を介してM期進行を促進する," 細胞工学, vol.32, no.9, 2013.9
渡辺 大輔
"今月の150〜200字でわかる海外の注目論文," 細胞工学, 2013.3
渡辺 大輔
"Overexpression of the yeast transcription activator Msn2 confers furfural resistance and increases the initial fermentation rate in ethanol production.," J. Biosci. Bioeng., vol.113, no.4, pp451-455, Apr. 2012
Sasano Y, Watanabe D, Ukibe K, Inai T, Ohtsu I, Shimoi H, Takagi H.
[ doi:10.1016/j.jbiosc.2011.11.017 ]
"Overexpression of the yeast transcription activator Msn2 confers furfural resistance and increases the initial fermentation rate in ethanol production.," J Biosci Bioeng., vol.113, no.4, pp451, Apr. 2012
Sasano Y, Watanabe D, Ukibe K, Inai T, Ohtsu I, Shimoi H, Takagi H.
"Sake yeast strains have difficulty in entering a quiescent state after cell growth cessation.," J. Biosci. Bioeng., vol.112, pp44, Jul. 2011
H. Urbanczyk, C. Noguchi, H. Wu, D. Watanabe, T. Akao, H. Takagi, H. Shimoi
"Sake yeast strains have difficulty in entering a quiescent state after cell growth cessation.," J. Biosci. Bioeng., 2011
H. Urbanczyk, C. Noguchi, H. Wu, D. Watanabe, T. Akao, H. Takagi, H. Shimoi
[ doi:10.1016/j.jbiosc.2011.03.001 ]
受賞
"生物工学論文賞," 日本生物工学会, 2019.9
D. Watanabe, M. Kumano, Y. Sugimoto, M. Ito, M. Ohashi, K. Sunada, T. Takahashi, T. Yamada, H. Takagi
"平成29年度日本醸造学会大会 技術賞," 日本醸造学会, 2017.10
渡辺 大輔
"トピックス賞," Isolation of baker's yeast mutants with proline accumulation that showed enhanced tolerance to baking-associated stresses. , Mar. 2017
Tsolmonbaatar Ariunzaya, 橋田恵介, 杉本幸子, 渡辺大輔, 古川周平, 高木博史
"Best Poster Award," The 14th International Congress on Yeasts, Sep. 2016
Minoru Ito, Daisuke Watanabe, Yukiko Sugimoto, Toshinari Takahashi, Hiroshi Takagi
"Carl Singer Foundation award," The 14th International Congress on Yeasts, Sep. 2016
Yuki Yoshikawa, Ryo Nasuno, Daisuke Watanabe, Hiroshi Takagi
"生物工学論文賞," 公益社団法人日本生物工学会, 2016.9
高木 博史, 橋田 恵介, 渡辺 大輔, 那須野 亮, 大橋 正孝, 伊波 朋哉, 鼠尾 まい子, 塚原 正俊
"農芸化学奨励賞," 農芸化学会, 2016.7
渡辺 大輔
"農芸化学奨励賞," 公益社団法人日本農芸化学会, 2016.2
渡辺 大輔
所属学協会
日本生物工学会
日本農芸化学会
日本醸造学会
酵母遺伝学フォーラム
酵母研究会
American Society for Microbiology
バイオインダストリー協会
資料

人類に身近な微生物がどのようにふるまい、他生物や環境要因とどのように相互作用することで複雑な生態系を構築するのかを分子・代謝・細胞レベルで明らかにし、ミクロの世界における多様性の理解を目指した研究・教育を行います。食と健康を意識したバイオ技術にも貢献していきます。

木俣 行雄

職位 准教授
領域 バイオサイエンス領域 統合システム生物学分野
研究室 ストレス微生物科学

微生物が進化の過程で獲得した様々な「環境ストレス」に対する適応機構について、分子・代謝・細胞レベルで解明し、多様な微生物機能を理解するとともに、微生物育種・物質生産などの技術開発を通して、バイオテクノロジーへの貢献を目指した研究・教育を行う。

両角 佑一

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 ストレス微生物科学

微生物が進化の過程で獲得した様々な「環境ストレス」に対する適応機構について、分子・代謝・細胞レベルで解明し、多様な微生物機能を理解するとともに、微生物育種・物質生産などの技術開発を通して、バイオテクノロジーへの貢献を目指した研究・教育を行う。

中瀬 由起子

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 ストレス微生物科学

微生物が進化の過程で獲得した様々な「環境ストレス」に対する適応機構について、分子・代謝・細胞レベルで解明し、多様な微生物機能を理解するとともに、微生物育種・物質生産などの技術開発を通して、バイオテクノロジーへの貢献を目指した研究・教育を行う。

磯貝 章太

職位 特任助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 ストレス微生物科学

微生物が進化の過程で獲得した様々な「環境ストレス」に対する適応機構について、分子・代謝・細胞レベルで解明し、多様な微生物機能を理解するとともに、微生物育種・物質生産などの技術開発を通して、バイオテクノロジーへの貢献を目指した研究・教育を行う。

木俣 有紀

職位 博士研究員
領域 バイオサイエンス領域 統合システム生物学分野
研究室 ストレス微生物科学

微生物が進化の過程で獲得した様々な「環境ストレス」に対する適応機構について、分子・代謝・細胞レベルで解明し、多様な微生物機能を理解するとともに、微生物育種・物質生産などの技術開発を通して、バイオテクノロジーへの貢献を目指した研究・教育を行う。

棚橋 亮弥

職位 博士研究員
領域 バイオサイエンス領域 統合システム生物学分野
研究室 ストレス微生物科学

微生物が進化の過程で獲得した様々な「環境ストレス」に対する適応機構について、分子・代謝・細胞レベルで解明し、多様な微生物機能を理解するとともに、微生物育種・物質生産などの技術開発を通して、バイオテクノロジーへの貢献を目指した研究・教育を行う。