研究キーワード
 インピーダンス信号計測, 微小・マイクロ・ナノ流体デバイス, ガラスのMEMS技術, バイオエンジニアリング, マイクロ製造
研究分野
 ものづくり技術（機械・電気電子・化学工学） / 電子デバイス、電子機器 / FPGA システム開発, ライフサイエンス / 生体医工学 / インピーダンス計測 電気イメージイング, ナノテク・材料 / ナノバイオサイエンス / ナノスケール試料の操作と計測, 情報通信 / 機械力学、メカトロニクス / 信号処理、高速ソーティングシステム, 情報通信 / ロボティクス、知能機械システム /
研究室概要
 レーザー技術、流体技術、顕微鏡技術を駆使した、細胞やタンパク質などの微小な生体材料を高速かつ高精度に操作する方法を開発し、これらの操作により生体材料にもたらされる諸現象を力学と生理学の両側面から明らかにし、工学に応用するための研究・教育を行う。
学術論文
"Accelerating image reconstruction of asynchronous optofluidic time-stretch imaging flow cytometry," Optics & Laser Technology, vol.187, pp112753, 2025.9.1
Jiehua Zhou, Zhuo Yin, Yan Ding, Xun Liu, Kaining Yang, Xiao Ma, Xiaoyang Chen, Yaxiaer Yalikun, Du Wang, Cheng Lei
"Gas Microbubble Formation via Near-Infrared Femtosecond Laser Ablation in Live Cells," ChemBioChem, 12 May. 2025
Kazunori Okano, Rieko Aida, Hayato Suwa, Naomi Tanga, Koichro Kishima, Yaxiaer Yalikun, Yoichiroh Hosokawa, andHiromi Hagiwara
[ doi:10.1002/cbic.202500086 ]
"Self-Powered Underwater Acoustic Detection Sensor based on Triboelectric Nanogenerator," Nano Energy, vol.111099, 9 May. 2025
Chang Xin Liu, Haonan Feng, Zhuhang Dai, Hai Zhang, Haoxiang Ma, Jia Du, Yaxiaer Yalikun, Chang Bao Han, Chenjing Shang, Yang Yang
[ doi:10.1016/j.nanoen.2025.111099 ]
"Double-emulsion droplet digital CRISPR/Cas12a for amplification-free, absolute quantification of nucleic acids at attomole levels," Chemical Engineering Journal, 2025.4.2
Yang Zhang, Hangrui Liu, Shi-Yang Tang, Yaxiaer Yalikun, Tracie J Barber, Keisuke Goda, Ming Li
[ doi:10.1016/j.cej.2025.162098 ]
"Progress of Cell Sorting in Flow Cytometry," iLABMED, 30 Mar. 2025
Baijun Cai, Jiaxuan Ding, Yaxiaer Yalikun, Dahai Ren
[ doi:10.1002/ila2.70000 ]
"Nanotechnology-Enabled Devices for Ocean Internet of Things," EcoMat, 20 Feb. 2025
Chenjing Shang, Yi Chen, Zhuhang Dai, Yaxiaer Yalikun, Lihua Qian, Pooi See Lee, Yang Yang
[ doi:10.1002/eom2.70003 ]
"Imaging flow cytometry with a real-time throughput beyond 1,000,000 events per second," Light: Science & Applications, vol.14,76(2025), 5 Feb. 2025
Jiehua Zhou, Liye Mei, Mingjie Yu, Xiao Ma, Dan Hou, Zhuo Yin, Xun Liu, Yan Ding, Kaining Yang, Ruidong Xiao, Xiandan Yuan, Yueyun Weng, Mengping Long, Taobo Hu, Jinxuan Hou, Yu Xu, Liang Tao, Sisi Mei, Hui Shen, Yaxiaer Yalikun, Fuling Zhou, Liang Wang, Du Wang, Sheng Liu, Cheng Lei
[ doi:10.1038/s41377-025-01754-9 ]
"CellSAM: Advancing Pathologic Image Cell Segmentation via Asymmetric Large-Scale Vision Model Feature Distillation Aggregation Network," Microscopy Research and Technique, pp1-15, 1 Feb. 2025
Xiao Ma, Jin Huang, Mengping Long, Xiaoxiao Li, Zhaoyi Ye, Wanting Hu, Yaxiaer Yalikun, Du Wang, Taobo Hu, Liye Mei, Cheng Lei
[ doi:10.1002/jemt.24716 ]
"STLNet: Symmetric transformer learning network for remote sensing image change detection," IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2024.12.20
Liye Mei, Andong Huang, Zhaoyi Ye, Yaxiaer Yalikun, Ying Wang, Chuan Xu, Wei Yang, Xinghua L
[ doi:10.1109/JSTARS.2024.3519305 ]
"Shape-Modified Ultrathin Glass Sheet Cantilever for Precise Single Cell Stiffness Measurement," ACS Measurement Science Au, 4 Dec. 2024
Yapeng Yuan, Chaoyang Lyu, Nobutoshi Ota, Ming Li, Cheng Lei, Yoichiroh Hosokawa, Yo Tanaka, Yang Yang, Yaxiaer Yalikun
[ doi:10.1021/acsmeasuresciau.4c00074 ]
"Shear Stress-based Purification Method for Human Pluripotent Stem Cell-derived Endothelial Cells," Circulation, 2024.11.11
Mosha Abulaiti, Wusiman Maihemuti, Kozue Murata, Laura Gonzalez-Teshima, Yaxiaer Yalikun, Hidetoshi Masumoto
[ doi:10.1161/circ.150.suppl_1.4142206 ]
"A Three-Dimensional Surface-Adaptive Stretchable Sensor for Online Monitoring of Composite Materials Curing," ACS sensors, 31 Oct. 2024
Wei Wang, Bowen Zhang, Haonan Feng, Zihong Wei, Zhuhang Dai, Hai Zhang, Haoxiang Ma, Yaxiaer Yalikun, Chenjing Shang, Yang Yang
[ doi:10.1021/acssensors.4c02022 ]
"Micro/Nano hierarchical dumbbell-like and micropapillae structure improves light absorption and facilitates anti-icing/de-icing performance," Langmuir, 29 Oct. 2024
Zhizhong Wang, Xiaoming Feng, Yaxiaer Yalikun, Fengqin Li, Yan Li, Lei Zhao, Tianlong Zhang, Guizhong Tian
[ doi:10.1021/acs.langmuir.4c03526 ]
"MRRM: Advanced biomarker alignment in multi-staining pathology images via multi-scale ring rotation-invariant matching," IEEE Journal of Biomedical and Health Informatics, 27 Oct. 2024
Xiaoxiao Li, Taobo Hu, Zhengxiong Li, Mengping Long, Zhaoyi Ye, Jin Huang, Yaxiaer Yalikun, Sheng Liu, Yiqiang Liu, Du Wang, Jianghua Wu, Liye Mei, Cheng Lei
[ doi:10.1109/JBHI.2024.3487630 ]
"Omni-directional harvesting of ocean wave energy using arch-shaped double-layered direct-current triboelectric nanogenerator," Nano Energy, pp110365, 17 Oct. 2024
Haonan Feng, Chang Xin Liu, Wei Wang, Zhuhang Dai, Hai Zhang, Haoxiang Ma, Yaxiaer Yalikun, Bowen Zhang, Chenjing Shang, Ying-Chih Lai, Yang Yang
[ doi:10.1016/j.nanoen.2024.110365 ]
"The Parameter Investigation of Electrical Impedance Cytometry for Droplet Measurement," IEEE Sensors Journal, 2024.8.30
Xun Liu, Tianlong Zhang, Tao Tang, Yapeng Yuan, Doudou Ma, Yang Yang, Guizhong Tian, Yoichiroh Hosokawa
[ doi:10.1109/JSEN.2024.3446991 ]
"Self-powered and speed-adjustable sensor for abyssal ocean current measurements based on triboelectric nanogenerators," Nature Communications, 20 Jul. 2024
Yuan Chao Pan, Zhuhang Dai, Haoxiang Ma, Jinrong Zheng, Jing Leng, Chao Xie, Yapeng Yuan, Wencai Yang, Yaxiaer Yalikun, Xuemei Song, Chang Bao Han, Chenjing Shang, Yang Yang
[ doi:10.1038/s41467-024-50581-w ]
"MSGM: An Advanced Deep Multi-Size Guiding Matching Network for Whole Slide Histopathology Images Addressing Staining Variation and Low Visibility Challenges," IEEE Publishing Operations, vol.2168-2194, 26 Jun. 2024
Xiaoxiao Li, Zhengxiong Li, Taobo Hu, Mengping Long, Xiao Ma, Jin Huang, Yiqiang Liu, Yaxiaer Yalikun, Sheng Liu, Du Wang, Jianghua Wu, Liye Mei, Cheng Lei
[ doi:10.1109/JBHI.2024.3417937 ]
"A triboelectric nanogenerator based on a spiral rotating shaft for efficient marine energy harvesting of the hydrostatic pressure differential," Materials Reports: Energy, pp100280, 2024.6.9
Xuemei Song, Yuan Chao Pan, Chang Bao Han, Chang Xin Liu, Yaxiaer Yalikun, Hui Yan, Yang Yang
[ doi:10.1016/j.matre.2024.100280 ]
"Emerging MEMS sensors for ocean physics: Principles, materials, and applications," Applied Physics Reviews, 2024.5.22
Yang Yang, Zhuhang Dai, Yi Chen, Yapeng Yuan, Yaxiaer Yalikun, Chenjing Shang
[ doi:10.1063/5.0194194 ]
"Enhanced CRISPR/Cas12a-based quantitative detection of nucleic acids using double emulsion droplets," Biosensors and Bioelectronics, vol.257, pp116339, 30 Apr. 2024
Yang Zhang, Hangrui Liu, Yuta Nakagawa, Yuzuki Nagasaka, Tianben Ding, Shi-Yang Tang, Yaxiaer Yalikun, Keisuke Goda, Ming Li
[ doi:10.1016/j.bios.2024.116339 ]
"Chronoamperometric interrogation of an electrochemical aptamer-based sensor with tetrahedral DNA nanostructure pendulums for continuous biomarker measurements," Analytica Chimica Acta, vol.1305, 23 Apr. 2024
Yizhou Wang, Haowei Duan, Yaxiaer Yalikun, Shaokoon Cheng, Ming Li
[ doi:10.1016/j.aca.2024.342587 ]
"Hybrid Attention-Aware Transformer Network Collaborative Multiscale Feature Alignment for Building Change Detection," IEEE Transactions on Instrumentation and Measurement , vol.73, 2024.3.14
Chuan Xu, Zhaoyi Ye, Liye Mei, Haonan Yu, Jianchen Liu, Yaxiaer Yalikun, Shuangtong Jin, Sheng Liu, Wei Yang, Cheng Lei
[ doi:10.1109/TIM.2024.3373089 ]
"Passive microfluidic devices for cell separation," Biotechnology Advances, 2024.1.16
Tianlong Zhang, Dino Di Carlo, Chwee Teck Lim, Tianyuan Zhou, Guizhong Tian, Tao Tang, Amy Q. Shen, Weihua Li, Ming Li, Yang Yang, Keisuke Goda, Ruopeng Yan, Cheng Lei, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.1016/j.biotechadv.2024.108317 ]
"High accuracy size-based droplet separation with pinched flow fractionation," Applied Physics Express, 2023.11.10
Xun Liu, Doudou Ma, Yapeng Yuan, Tao Tang, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.35848/1882-0786/ad0b41 ]
"Machine Learning Implementation Strategy in Imaging and Impedance Flow Cytometry ," Biomicrofluidics, vol.17, 30 Oct. 2023
Trisna Julian, Tao Tang, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.1063/5.0166595 ]
"A cost-effective and high-sensitivity optofluidic refractive index sensor for rapid edible oil analysis," IEEE Sensors Journal, 7 Sep. 2023
Ruopeng Yan, Xun Liu, Shuang Zhao, Chi Zhang, Liang Wang, Yaxiaer Yalikun, Du Wang, Cheng Lei
[ doi:10.1109/JSEN.2023.3311421 ]
"Guided Axon Outgrowth of Neurons by Molecular Gradients Generated from Femtosecond Laser-Fabricated Micro-Holes," Talanta, Sep. 2023
Dian Anggraini, Tianlong Zhang, Xun Liu, Kazunori Okano, Yo Tanaka, Naoyuki Inagaki, Ming Li, Yoichiroh Hosokawa, Sohei Yamada
"A pendulum-type electrochemical aptamer-based sensor for continuous, real-time and stable detection of proteins," Talanta , 4 Aug. 2023
Yizhou Wang, Haowei Duan, Yaxiaer Yalikun, Shaokoon cheng, Ming Li
[ doi:10.1016/j.talanta.2023.125026 ]
"Inertial Separation of Particles Assisted by Symmetrical Sheath Flows in a Straight Microchannel," Analytical chemistry, Jul. 2023
Tianlong Zhang, David W. Inglis, Long Ngo, Yuling Wang, Yoichiroh Hosokawa, Yaxiaer Yalikun, Ming Li
[ doi:10.1021/acs.analchem.3c02089 ]
"10 µm thick ultra-thin glass sheet to realize a highly sensitive cantilever for precise cell stiffness measurement," Lab on a chip, Jul. 2023
Yapeng Yuan, Doudou Ma, Xun Liu, Tao Tang, Ming Li, Yang Yang, Yo Tanaka
[ doi:10.1039/D3LC00113J ]
"An optimized PDMS microfluidic device for ultra-fast and high-throughput imaging flow cytometry," Lab on a chip, Jun. 2023
Xun Liu, jiehua Zhou, Ruopeng Yan, Tao Tang, Shubin Wei, Rubing Li, Dan Hou, Yueyun Weng, Du Wang, Hui Shen, Fuling Zhou, Yo Tanaka, Ming Li, Yoichiroh Hosokawa, Cheng Lei
[ doi:10.1039/D3LC00237C ]
"A review on intelligent impedance cytometry systems: Development, applications and advances," Analytica Chimica Acta, 30 May. 2023
Tao Tang, Trisna Julian, Doudou Ma, Yang Yang, Ming Li, Yoichiroh Hosokawa
[ doi:10.1016/j.aca.2023.341424 ]
"Bacteria separation and enrichment using viscoelastic flows in a straight microchannel," Sensors and Actuators B: Chemical, vol.390, pp133918, 5 May. 2023
Tianlong Zhang, Amy K. Cain, Lucie Semenec, Joanna Valanie Pereira, Yoichiroh Hosokawa, Ming Li
[ doi:10.1016/j.snb.2023.133918 ]
"A Guided-Liquid-Based Hybrid Triboelectric Nanogenerator for Omnidirectional and High-Performance Ocean Wave Energy Harvesting," Nano Energy, 28 Jan. 2023
Qingyue Xu, Chenjing Shang, Haoxiang Ma, Quan Hong, Changzheng Li, Su Ding, Liang Xue, Xin Sun, Yuanchao Pan, Tohru Sugahara, Yaxiaer Yalikun, Ying-Chih Lai
[ doi:10.1016/j.nanoen.2023.108240 ]
"Microfluidic Separation and Enrichment of Escherichia coli by Size Using Viscoelastic Flows," Analytical Chemistry, 19 Jan. 2023
Tianlong Zhang, Amy K. Cain, Lucie Semenec, Ling Liu, Yoichiroh Hosokawa, David W. Inglis
[ doi:10.1021/acs.analchem.2c05084 ]
"Microsecond cell triple-sorting enabled by multiple pulse irradiation of femtosecond laser," Scientific Reports, 9 Jan. 2023
Ryota Kiya, Tao Tang, Yo Tanaka, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.1038/s41598-022-27229-0 ]
"Machine learning-based impedance system for real-time recognition of antibiotic-susceptible bacteria with parallel cytometry.," Sensors and Actaurtors B: Chemical, vol.374, 1 Jan. 2023
Tang, T, Liu, X, Yuan, Y, Kiya, R, Zhang, T, Yang, Y, Suetsugu, S, Yamazaki, Y, Ota, N, Yamamoto, K, Kamikubo, H, Tanaka, Y, Li, M, Hosokawa, Y., Yalikun, Y.
[ doi:10.1016/j.snb.2022.132698 ]
"DOUBLE PULSE IRRADIATION OF FS LASER FOR ENHANCING THE PERFORMANCE OF PRECISE LASER SORTING METHOD," The 36th International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2023), Jan. 2023
Ryota Kiya, Yoshinaga Rintaro, Yo Tanaka, Yaxiaer Yalikun, Yoichiroh Hosokawa
"Multi-scale integrated temperature/flow velocity sensor patches for microfluidic applications," IEEE Sensors Journal, 23 Dec. 2022
Yigang Shen, Yapeng Yuan, Xun Liu, Tao Tang, Yaxiaer Yalikun, Yo Tanaka
[ doi:10.1109/jsen.2022.3230692 ]
"Multi-position measurable flow velocity sensor for microfluidic applications with small invasiveness," IEEE Sensors Journal, 9 Dec. 2022
Yansheng Hao, Chaoying Fang, Yapeng Yuan, Kazunori Okano, Ryohei Yasukuni, Shaokoon Cheng, Yo Tanaka, Yoichiroh Hosokawa, Yang Yang, Ming Li, Yaxiaer Yalikun
[ doi:10.1109/jsen.2022.3225637 ]
"Microenvironmental Analysis and Control for Local Cells under Confluent Conditions via a Capillary-Based Microfluidic Device," Analytical Chemistry, vol.94, pp16299-16307, 16 Nov. 2022
Nobutoshi Ota, Nobuyuki Tanaka, Asako Sato, Yigang Shen, Yaxiaer Yalikun, Yo Tanaka
[ doi:10.1021/acs.analchem.2c02815 ]
"Machine learning-based impedance system for real-time recognition of antibiotic-susceptible bacteria with parallel cytometry ," Sensors and Actuators B: Chemical, pp132698, 30 Oct. 2022
Tao Tang, Xun Liu, Yapeng Yuan, Ryota Kiya, Tianlong Zhang, Yang Yang, Shiro Suetsugu, Yoichi Yamazaki, Nobutoshi Ota, Koki Yamamoto, Hironari Kamikubo, Yo Tanaka, Ming Li, Yoichiroh Hosokawa
[ doi:10.1016/j.snb.2022.132698 ]
"Parallel Impedance Cytometry for Real-Time Screening of Bacterial Single Cells from Nano- to Microscale ," ACS sensor, 25 Oct. 2022
Tao Tang, Xun Liu, Yapeng Yuan, Tianlong Zhang, Ryota Kiya, Yang Yang, Yoichi Yamazaki, Hironari Kamikubo, Yo Tanaka, Ming Li, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.1021/acssensors.2c013 ]
"Identification of Single Yeast Budding Using Impedance Cytometry with a Narrow Electrode Span," Sensors, 20 Oct. 2022
Xun Liu, Tao Tang, Po-Wei Yi, Yapeng Yuan, Cheng Lei, Ming Li, Yo Tanaka, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.3390/s22207743 ]
"A pressure driven electric energy generator exploiting a micro- to nano-scale glass porous filter with ion flow originating from water ," Scientific Reports, 20 Oct. 2022
Yo Tanaka, Satoshi Amaya, Shun-ichi Funano, Hisashi Sugawa, Wataru Nagafuchi, Yuri Ito, Yusufu Aishan, Xun Liu, Norihiro Kamamichi, Yaxiaer Yalikun
[ doi:10.1038/s41598-022-2106 ]
"Reverse sorting of immortalized megakaryocyte progenitor cell lines (imMKCLs) by femtosecond laser scanning," Applied Physics Express, vol.15, 14 Sep. 2022
Anggraini Dian, Wildan Mubarok, Yoichiroh Hosokawa, Koji Eto, Shiro Suetsugu, Yaxiaer Yalikun
[ doi:10.35848/1882-0786/ac8f17 ]
"Reverse sorting of immortalized megakaryocyte progenitor cell lines (imMKCLs) by femtosecond laser scanning.," Applied Physics Express, 2 Sep. 2022
D Anggraini, W Mubarok, Y Hosokawa, K Eto, S Suetsugu, Y Yalikun.
[ doi:10.35848/1882-0786/ac8f17 ]
"熱膨張によるガラスマイクロレンズアレイ製造法 ," 光アライアンス, vol.33(8), pp46-49, 2022.8
田中 陽, Yalikun Yaxiaer, アイサン ユスフ
"Anhydrobiotic chironomid larval motion-based multi-sensing microdevice for the exploration of survivable locations," iScience, 20 Jul. 2022
Yo Tanaka, Doudou Ma, Satoshi Amaya, Yusufu Aishan, Yigang Shen, Shun-ichi Funano, Tao Tang, Yoichiroh Hosokawa, Oleg Gusev, Takashi Okuda, Takahiro Kikawada, Yaxiaer Yalikun
[ doi:10.1016/j.isci.2022.104639 ]
"A tube-shaped solid–liquid-interfaced triboelectric–electromagnetic hybrid nanogenerator for efficient ocean wave energy harvesting," Nano Energy, vol.100, 26 Jun. 2022
Xin Sun, Chenjing Shang, Haoxiang Ma, Changzheng Li, Liang Xue, Qingyue Xu, Zihong Wei, Wanli Li, Yaxiaer Yalikun, Ying-Chih Lai, Yang Yang
[ doi:10.1016/j.nanoen.2022.107540 ]
"Assessment of the electrical penetration of cell membranes using four-frequency impedance cytometry," Microsystems & Nanoengineering, vol.8, 24 Jun. 2022
Tao Tang, Xun Liu, Yapeng Yuan, Tianlong Zhang, Ryota Kiya, Yang Yang, Kengo Suzuki, Yo Tanaka, Ming Li, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.1038/s41378-022-00405-y ]
"Bio-actuated microvalve in microfluidics using sensing and actuating function of Mimosa pudica," Scientific Reports, vol.12, 23 May. 2022
Yusufu Aishan, Shun‐ichi Funano, Asako Sato, Yuri Ito, Nobutoshi Ota, Yaxiaer Yalikun, Yo Tanaka
[ doi:10.1038/s41598-022-11637-3 ]
"Shape-based separation of drug-treated Escherichia coli using viscoelastic microfluidics," Lab on a Chip, vol.22, pp 2801-2809, 6 May. 2022
Tianlong Zhang, Hangrui Liu, Kazunori Okano, Tao Tang, Kazuki Inoue, Yoichi Yamazaki, Hironari Kamikubo, Amy K Cain, Yo Tanaka, David W Inglis, Yoichiroh Hosokawa, Yaxiaer Yalikun, Ming Li
[ doi:10.1039/D2LC00339B ]
"Recent advances in microfluidic devices for single-cell cultivation: methods and applications," Lab on a Chip, vol.22, pp1438-1468, 26 Feb. 2022
Dian Anggraini, Nobutoshi Ota, Yigang Shen, Tao Tang, Yo Tanaka, Yoichiroh Hosokawa, Ming Li, Yaxiaer Yalikun
[ doi:10.1039/d1lc01030a ]
"A gas flow velocity sensor fabricated with femtosecond laser using 4 μm ultra-thin glass sheet," Applied Physics Express, vol.15, 2 Feb. 2022
Yansheng Hao, Yo Tanaka, Yoichiroh Hosokawa, Ming Li, Yaxiaer Yalikun
[ doi:10.35848/1882-0786/ac516d ]
"Impedance-based tracking of the loss of intracellular components in microalgae cells," Sensors and Actuators B: Chemical, vol.358, 1 Feb. 2022
Tao Tang, Xun Liu, Yapeng Yuan, Tianlong Zhang, Ryota Kiya, Kengo Suzuki, Yo Tanaka, Ming Li, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.1016/j.snb.2022.131514 ]
"Continuous 3D particles manipulation based on cooling thermal convection," Sensors and Actuators B: Chemical, vol.358, 31 Jan. 2022
Yigang Shen, Yapeng Yuan, Tao Tang, Nobutoshi Ota, Nobuyuki Tanaka, Yoichiroh Hosokawa, Yaxiaer Yalikun, Yo Tanaka
[ doi:10.1016/j.snb.2022.131511 ]
"Dual-frequency impedance assays for intracellular components in microalgal cells," Lab on a Chip, vol.22, pp550-559, 18 Nov. 2021
Tao Tang, Xun Liu, Yapeng Yuan, Ryota Kiya, Yigang Shen, Tianlong Zhang, Kengo Suzuki, Yo Tanaka, Ming Li, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.1039/d1lc00721a ]
"Specific capture and intact release of breast cancer cells using a twin-layer vein-shaped microchip with a self-assembled surface," Nanoscale, 9 Sep. 2021
Yixing Gou, Zhuyuan Chen, Changku Sun, Peng Wang, Zheng You, Yaxiaer Yalikun, Yo Tanaka, Dahai Ren
[ doi:10.1039/d1nr04018a ]
"Guided Axon Outgrowth of Neurons by Real-Time Femtosecond Laser Penetration on a 4 μm Thick Thin-Glass Sheet," bioRχiv, 2021.8.19
Dian Anggraini, Xun Liu, Kazunori Okano, Yo Tanaka, Naoyuki Inagaki, Ming Li, Yoichiroh Hosokawa, Sohei Yamada, Yaxiaer Yalikun
[ doi:10.1101/2021.08.17.456633 ]
"Focusing of Particles in a Microchannel with Laser Engraved Groove Arrays," Biosensors, vol.11, pp263-263, 4 Aug. 2021
Tianlong Zhang, Yigang Shen, Ryota Kiya, Dian Anggraini, Tao Tang, Hanaka Uno, Kazunori Okano, Yo Tanaka, Yoichiroh Hosokawa, Ming Li
[ doi:10.3390/bios11080263 ]
"Microscopic impedance cytometry for quantifying single cell shape," Biosensors and Bioelectronics, vol.193, 2 Aug. 2021
Tao Tang, Xun Liu, Ryota Kiya, Yigang Shen, Yapeng Yuan, Tian long Zhang, Kengo Suzuki, Yo Tanaka, Ming Li, Yoichiroh Hosokawa, Yaxiaer Yalikun
[ doi:10.1016/j.bios.2021.113521 ]
"A chemical micropump actuated by self-oscillating polymer gel," Sensors and Actuators B: Chemical, vol.337, pp129769, 15 Jun. 2021
Yusufu Aishan, Yaxiaer Yalikun, Yigang Shen, Yapeng Yuan, Satoshi Amaya, Takashi Okutaki, Atsuhito Osaki, Shingo Maeda, Yo Tanaka
[ doi:10.1016/j.snb.2021.129769 ]
"Fabrication of ultra-thin glass sheet by weight-controlled load-assisted precise thermal stretching," Sensors and Actuators A: Physical, vol.321, pp112604, 15 Apr. 2021
Yapeng Yuan, Yaxiaer Yalikun, Satoshi Amaya, Yusufu Aishan, Yigang Shen, YoTanaka
[ doi:10.1016/j.sna.2021.112604 ]
"Glass based micro total analysis systems: Materials, fabrication methods, and applications," Sensors and Actuators B: Chemical, vol.339, 26 Mar. 2021
Tao Tang, Yapeng Yuan, Yaxiaer Yalikun, Yoichiroh Hosokawa, Ming Li, Yo Tanaka
[ doi:10.1016/j.snb.2021.129859 ]
"Rotation of Biological Cells: Fundamentals and Applications," Engineering, 19 Jan. 2021
Tao Tang, Yoichiroh Hosokawa, Takeshi Hayakawa, Yo Tanaka, Weihua Li, Ming Li, Yaxiaer Yalikun
[ doi:10.1016/j.eng.2020.07.031 ]
"Hydrodynamic particle focusing enhanced by femtosecond laser deep grooving at low Reynolds numbers," Scientific Reports, vol.11, Article number: 1652, 18 Jan. 2021
Tianlong Zhang, Misuzu Namoto, Kazunori Okano, Eri Akita, Norihiro Teranishi, Tao Tang, Dian Anggraini, Yansheng Hao, Yo Tanaka, David Inglis, Yaxiaer Yalikun, Ming Li, Yoichiroh Hosokawa
[ doi:10.1038/s41598-021-81190-y ]
"In situ measurement of cell stiffness of Arabidopsis roots growing on a glass micropillar support by atomic force," Plant Biotechnology, vol.37 No.4, pp417-422, 11 Dec. 2020
Eri Akita, Yaxiaer Yalikun, Kazunori Okano, Yuki Yamasaki, Misato Ohtani, Yo Tanaka, Taku Demura, Yoichiroh Hosokawa
[ doi:10.5511/plantbiotechnology.20.1016a ]
"Single-cell cultivation utilizing microfluidic systems," Handbook of Single Cell Technologies, pp1-24, 14 Nov. 2020
Dian Anggraini, Ota Nobutoshi, Yigang Shen, Yo Tanaka, Yoichiroh Hosokawa, Ming Li, Yaxiaer Yalikun
[ doi:10.1007/978-981-10-4857-9_20-1 ]
"Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function," Scientific Reports, vol.10, Article number: 19201, 5 Nov. 2020
Mosha Abulaiti, Yaxiaer Yalikun, Kozue Murata, Asako Sato, Mustafa M. Sami, Yuko Sasaki, Yasue Fujiwara, Kenji Minatoya, Yuji Shiba, Yo Tanaka, Hidetoshi Masumoto
[ doi:10.1038/s41598-020-76062-w ]
"Mechanical properties of single cells: Measurement methods and applications," Biotechnology Advances, vol.45, pp107648, 17 Oct. 2020
Yansheng Hao, Shaokoon Cheng, Yo Tanaka, Yoichiroh Hosokawa, Yaxiaer Yalikun, Ming Li
[ doi:10.1016/j.biotechadv.2020.107648 ]
"Area cooling enables thermal positioning and manipulation of single cells," Lab on a Chip, vol.20, pp3733-3743, 1 Oct. 2020
Yigang Shen, Yaxiaer Yalikun, Yusufu Aishan, Nobuyuki Tanaka, Asako Sato, Yo Tanaka
[ doi:10.1039/D0LC00523A ]
"Pneumatically Actuated Thin Glass Microlens for On-Chip Multi-Magnification Observations," Actuators, vol.9, Issue3, 22 Jun. 2020
Yusufu Aishan, Yaxiaer Yalikun, Yo Tanaka
[ doi:10.3390/act9030073 ]
"低ばね定数AFMカンチレバーを用いたフェムト秒レーザー誘起衝撃力の高感度検出手法の開発," 電気学会　光・量子デバイス研究会資料, vol.OQD-20-029, pp13-17, 2020.3.27
荒木崇志, Tang Tao, Yaxiaer Yalikun, 安國良平, 細川陽一郎
"Accurate rotation of ultra-thin glass chamber for single-cell multidirectional observation," Applied Physics Express, vol.13, pp026502, 9 Jan. 2020
Yusufu Aishan, Yaxiaer Yalikun, Shun-ichi Funano, Yigang Shen, Yo Tanaka
[ doi:10.7567/1882-0786/ab626d ]
"Horizontal connection method for glass microfluidic devices," Micro & Nano Letters, vol.15(5), pp333-338, Jan. 2020
Yaxiaer Yalikun, Nobutoshi Ota, Doudou Ma, Yo Tanaka
[ doi:10.1049/mnl.2019.0603 ]
"Thin glass micro-dome structure based microlens fabricated by accurate thermal expansion of microcavities ," Applied Physics Letters, vol.Vol.115, pp263501 , 26 Dec. 2019
Yusufu Aishan, Yaxiaer Yalikun, Satoshi Amaya, Yigang Shen, Yo Tanaka
[ doi:10.1063/1.5123186 ]
"Sheathless Inertial Focusing Chip Combining a Spiral Channel with Periodic Expansion Structures for Efficient and Stable Particle Sorting," Analytical Chemistry, vol.92, 2, pp1833-1841, 20 Dec. 2019
Yixing Gou, Shuai Zhang, Changku Sun, Peng Wang, Zheng You, Yaxiaer Yalikun, Yo Tanaka, Dahai Ren
[ doi:10.1021/acs.analchem.9b03692 ]
"Effects of Flow‐Induced Microfluidic Chip Wall Deformation on Imaging Flow Cytometry," Cytometry A, 19 Dec. 2019
Yaxiaer Yalikun, Nobutoshi Ota, Baoshan Guo, Tao Tang, Yuqi Zhou, Cheng Lei, Hirofumi Kobayashi, Yoichiroh Hosokawa, Ming Li, Hector Enrique Muñoz, Dino Di Carlo, Keisuke Goda, Yo Tanaka
[ doi:10.1002/cyto.a.23944 ]
"Focusing of Submicrometer Particles in Microfluidic Devices," Lab on a chip, 7 Nov. 2019
Tianlong Zhang, Zhen-Yi Hong, Shi-Yang Tang, Weihua Li, David W. Inglis, Yoichiroh Hosokawa, Yaxiaer Yalikun, Ming Li
[ doi:10.1039/C9LC00785G ]
"High-speed micro-particle manipulation in a microfluidic chip by directional femtosecond laser impulse," Sensors and Actuators A: Physical, vol.297, pp111566, 1 Oct. 2019
Zhen-Yi Hong, Kazunori Okano, Dino Di Carlo, Katsunori Tanaka, Yaxiaer Yalikun, Yoichiroh Hosokawa
[ doi:10.1016/j.sna.2019.111566 ]
"An ultra-small fluid oscillation unit for pumping driven by self-organized three-dimensional bridging of pulsatile cardiomyocytes on elastic micro-piers," Sensors and Actuators B: Chemical, vol.293, pp256-264, 15 Aug. 2019
Nobuyuki Tanaka, Tadahiro Yamashita, Yaxiaer Yalikun, Satoshi Amaya, Asako Sato, Viola Vogel, YoTanaka
[ doi:10.1016/j.snb.2019.04.087 ]
"Label-free chemical imaging flow cytometry by high-speed multicolor stimulated Raman scattering," PNAS, vol.116 (32), pp15842-15848, 19 Jul. 2019
Yuta Suzuki, Koya Kobayashi, Yoshifumi Wakisaka, Dinghuan Deng, Shunji Tanaka, Chun-Jung Huang, Cheng Lei, Chia-Wei Sun, Hanqin Liu, Yasuhiro Fujiwaki, Sangwook Lee, Akihiro Isozaki, Yusuke Kasai, Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai, Kenichi Koizumi, Hiroshi Tezuka, Mary Inaba, Kei Hiraki, Takuro Ito, Misa Hase, Satoshi Matsusaka, Kiyotaka Shiba, Kanako Suga, Masako Nishikawa, Masahiro Jona, Yutaka Yatomi, Yaxiaer Yalikun, Yo Tanaka, Takeaki Sugimura, Nao Nitta, Keisuke Goda, Yasuyuki Ozeki
[ doi:10.1073/pnas.1902322116 ]
"Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia," Lab on a Chip, vol.Lab Chip, 2019, 19, pp2688-2698, 9 Jul. 2019
Hirofumi Kobayashi, Cheng Lei, Yi Wu, Chun-Jung Huang, Atsushi Yasumoto, Masahiro Jona, Wenxuan Li, Yunzhao Wu, Yaxiaer Yalikun, Yiyue Jiang, Baoshan Guo, Chia-Wei Sun, Yo Tanaka, Makoto Yamada, Yutaka Yatomi, Keisuke Goda
[ doi:10.1039/C8LC01370E ]
"Isolating Single Euglena gracilis Cells by Glass Microfluidics for Raman Analysis of Paramylon Biogenesis," ACS Analytical Chemistry, vol.91, 15, pp9631-9639, 8 Jul. 2019
Nobutoshi Ota, Yusuke Yonamine, Takuya Asai, Yaxiaer Yalikun, Takuro Ito, Yasuyuki Ozeki, Yu Hoshino, Yo Tanaka
[ doi:10.1021/acs.analchem.9b01007 ]
"A valve powered by earthworm muscle with both electrical and 100% chemical control," Scientific Reports, vol.9, Article number: 8042, 8 Jul. 2019
Yo Tanaka, Shun-ichi Funano, Yuji Noguchi, Yaxiaer Yalikun, amp; Norihiro Kamamichi
[ doi:10.1038/s41598-019-44116-3 ]
"Insect Muscular Tissue-Powered Swimming Robot," Actuators, vol.8(2), 8 Apr. 2019
Yaxiaer Yalikun, Kaoru Uesugi, Minamida Hiroki, Yigang Shen, Yo Tanaka, Yoshitake Akiyama, Keisuke Morishima
[ doi:10.3390/act8020030 ]
"Enhancement in acoustic focusing of micro and nanoparticles by thinning a microfluidic device," Royal Society Open Science, vol.Volume 6, Issue 2, 20 Feb. 2019
Nobutoshi Ota, Yaxiaer Yalikun, Tomoyuki Suzuki, Sang Wook Lee, Yoichiroh Hosokawa, Keisuke Goda, Yo Tanaka
[ doi:10.1098/rsos.181776 ]
"Simple isolation of single cell: Thin glass microfluidic device for observation of isolated single euglena gracilis cells," Analytical Sciences, vol.Vol.35, No.5, pp577-583, 25 Jan. 2019
Nobutoshi Ota, Yaxiaer Yalikun, Nobuyuki Tanaka, Yigang Shen, Yusufu Aishan, Yuki Nagahama, Minoru Oikawa, Yo Tanaka
[ doi:10.2116/analsci.18P568 ]
"Recent advances in microfluidic cell sorting systems," Sensors and Actuators B: Chemical, vol.282, pp268-281, Nov. 2018
Yigang Shen, Yaxiaer Yalikun, Yo Tanaka
[ doi:10.1016/j.snb.2018.11.025 ]
"SLIDE-IN HORIZONTAL MICROFLUIDIC CONNECTION METHOD FOR HIGH PRESSURE/SPEED ON-CHIP APPLICATION," MicroTAS 2018, Nov. 2018
Yaxiaer Yalikun, Yoichiroh Hosokawa, Nobutoshi Ota, Yo Tanaka
"Femtosecond Laser-Activated High-Speed Manipulation of Microparticles in Microfluidic Chip with Assistance of Modified Channel Structure," The 22th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Nov. 2018
Zhen-Yi Hong, Yaxiaer Yalikun, Takanori Iino, Kazunori Okano, Dino Di Carlo, Ryohei Yasukuni, Yoichiroh Hosokawa
"Time sequential single-cell patterning with high 3 efficiency and high density," Sensors, vol.in press, Oct. 2018
Yang Liu, Dahai Ren, Xixin Ling, Weibin Liang, Jing Li, Zheng You, Yaxiaer Yalikun, Yo Tanaka
"Property investigation of replaceable PDMS membrane as an actuator in microfluidic device," Actuators, vol.7, 68, 28 Sep. 2018
Yapeng Yuan, Yaxiaer Yalikun, Nobutoshi Ota, Yo Tanaka
"Applications and Manipulation Method of Microbeads in Biological Field," Biomed J Sci & Tech Res, vol.Volume 9, Issue 1, pp1742, 17 Sep. 2018
Yapeng Yuan, Yaxiaer Yalikun, Yo Tanaka
"Intelligent Image-Activated Cell Sorting," Cell, vol.175, pp266-276, 27 Aug. 2018
Nao Nitta, Takeaki Sugimura, Akihiro Isozaki, Hideharu Mikami, Kei Hiraki, Shinya Sakuma, Takanori Iino, Fumihito Arai, Taichiro Endo, Yasuhiro Fujiwaki, Hideya Fukuzawa, Misa Hase, Takeshi Hayakawa, Kotaro Hiramatsu, Yu Hoshino, Mary Inaba, Takuro Ito, Hiroshi Karakawa, Yusuke Kasai, Kenichi Koizumi, SangWook Lee, Cheng Lei, Ming Li, Takanori Maeno, Satoshi Matsusaka, Daichi Murakami, Atsuhiro Nakagawa, Yusuke Oguchi, Minoru Oikawa, Tadataka Ota, Kiyotaka Shiba, Hirofumi Shintaku, Yoshitaka Shirasaki, Kanako Suga, Yuta Suzuki, Nobutake Suzuki, Yo Tanaka, Hiroshi Tezuka, Chihana Toyokawa, Yaxiaer Yalikun, Makoto Yamada, Mai Yamagishi, Takashi Yamano, Atsushi Yasumoto, Yutaka Yatomi, Masayuki Yazawa, Dino Di Carlo, Yoichiroh Hosokawa, Sotaro Uemura, Yasuyuki Ozeki, Keisuke Goda
"Embryonic body culturing in an all-glass microfluidic device with laser-processed 4 μm thick ultra-thin glass sheet filter," Biomed Microdevices, vol.19, 85, 19 Sep. 2017
Yaxiaer Yalikun, Nobuyuki Tanaka, Yoichiroh Hosokawa, Takayuki Iino, Yo Tanaka
受賞
"Big-on-Small Award Nominations 2022," International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), 2022.7.25
Yalikun Yaxiaer
"ORAL SESSION AWARD," TOIN International Symposium on Biomedical Engineering , 2020.11.8
Tianlong Zhang, Yaxiaer Yalikun, Ryota Kiya, Hanaka Uno, Kazunori Okano, Yo Tanaka, Ming Li, Yoichiroh Hosokawa
"ORAL SESSION AWARD - Prize of Gold," TOIN International Symposium on Biomedical Engineering 2019, 16 Nov. 2019
Yusuke Ajikawa, Tomoyuki Suzuki, Yaxiaer Yalikun, Kazunori Okano, Yoichiroh Hosokawa
"優秀口頭発表賞," 植物構造オプト若手の会, 2019.11.10
秋田絵理, 竹林竜, 岡野和宣, Yalikun Yaxiaer, 岸田佳祐, 國枝正, 大谷美沙都, 出村拓, 澤進一郎, 細川陽一郎
所属学協会
 レーザ加工学会
日本機械学会
資料
他の研究者

細川　陽一郎

職位 教授
領域 物質創成科学領域 基幹研究室
研究室 生体プロセス工学

レーザー技術、流体技術、顕微鏡技術を駆使した、細胞やタンパク質などの微小な生体材料を高速かつ高精度に操作する方法を開発し、これらの操作により生体材料にもたらされる諸現象を力学と生理学の両側面から明らかにし、工学に応用するための研究・教育を行う。

釣　優香

職位 助教
領域 物質創成科学領域 基幹研究室
研究室 生体プロセス工学

レーザー技術、流体技術、顕微鏡技術を駆使した、細胞やタンパク質などの微小な生体材料を高速かつ高精度に操作する方法を開発し、これらの操作により生体材料にもたらされる諸現象を力学と生理学の両側面から明らかにし、工学に応用するための研究・教育を行う。

丹賀　直美

職位 特任助教
領域 デジタルグリーンイノベーションセンター デジタルグリーンイノベーションセンター
研究室 デジタルグリーンイノベーション部門