秋山 昌広

所属 バイオサイエンス領域 統合システム生物学分野
職位 准教授
学位
研究室 原核生物分子遺伝学
研究キーワード
DNAコーミング, DNA複製フォーク, 一分子解析, 細胞死, ストレス応答, バクテリア, 細胞周期, DNA修復, DNAポリメラーゼ, DNA複製, Transletion DNA Synthesis, Cell death, Stress response, Cell cycle, DNA Repair, DNA Polymerase, DNA Replication
研究分野
ライフサイエンス / 分子生物学 / , ライフサイエンス / 遺伝学 /
研究室概要
ゲノムの正確な複製がどのような仕組みに支えられているのか、あるいはこれとは逆に、ゲノムの不正確な複製によって引き起こされる突然変異や染色体異常はどのようなプロセスを経て発生するのかについて研究・教育を行う。
学術論文
"Nutritional conditions and oxygen concentration affect spontaneous occurrence of homologous recombination events but not spontaneous mutagenesis in Escherichia coli," Genes and Genetic Systems, vol.95, pp85-93, 11 May. 2020
Lan Anh Thi Le, Phooi Yee Chang, Sayaka Ando, Thomas Conrad, Shohei Nunose, Akiko Sakai, Haruka Uefune, Asako Furukohri, Masahiro Akiyama, Hisaji Maki
"Collision with duplex DNA renders Escherichia coli DNA polymerase III holoenzyme susceptible to DNA polymerase IV-mediated polymerase switching on the sliding clamp," Scientific Reports, vol.in press, 18 Sep. 2017
Thanh Thi Le, Asako Furukori, Masahiro Akiyama, Hisaji Maki
"Replication fork progression is paused in two large chromosomal zones flanking the DNA replication origin in Escherichia coli. ," Gene to Cells, vol.21, pp907-914, 16 Mar. 2016
Masahiro Akiyama, Taku Oshima, Omuma Chumsakul, Shu Ishikawa, Hisaji Maki
[ doi:10.1111/gtc.12388 ]
"Recombinase and translesion DNA polymerase decrease the speed of replication fork progression during the DNA damage response in Escherichia coli cells," Nucleic Acids Research, vol.43, pp1714-1725, 12 Jan. 2015
Kang Tan Wei, Tuan Minh Pham, Asako Furukohri, Hisaji Maki, Masahiro Akiyama
[ doi:10.1093/nar/gkv044 ]
"DNA polymerase IV mediates efficient and quick recovery of replication forks stalls at N2-dG adducts," Nucleic Acids Research, vol.42, no.13, pp8461-8472, 23 Jun. 2014
Mio Ikeda, Asako Furukohri, Masahiro Akiyama, Tsutomu Katayama, Robert P. Fuchs, Hisaji Maki
"A single-molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerase III is a major determinant of fork speed," Molecular Microbiology, 27 Aug. 2013
Pham Minh Tuan, Tan Kang Wei, 作村諭一, 奥村克純, Hisaji Maki, Masahiro Akiyama
"A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen.," Org Biomol Chem., vol.11, pp2567-2570, 28 Apr. 2013
Komeda C, Ikeda A, Junichi Kikuchi, Ishida-Kitagawa N, Tatebe H, Shiozaki K, Akiyama M.
[ doi:10.1039/c2ob27199k ]
"Advantages and Potential of Lipid Membrane-Incorporating Fullerenes Prepared by the Exchange Reaction Method," Chem. -Asian J., vol.7, no.3, pp605, May. 2012
A. Ikeda, M. Mori, K. Kiguchi, K. Yasuhara, J. Kikuchi, K. Nobusawa, M. Akiyama, M. Hashizume, T. Ogawa, T. Takeya
"Advantages and Potential of Lipid-Membrane-Incorporating Fullerenes Prepared by the Fullerene-Exchange Method.," Chem Asian J., vol.7, no.3, pp605, Mar. 2012
Ikeda A, Mori M, Kiguchi K, Yasuhara K, Kikuchi JI, Nobusawa K, Akiyama M, Hashizume M, Ogawa T, Takeya T.
"Pseudorotaxane Structure of a Fullerene Derivative–Cyclodextrin 1:2 Complex," Chem. Commun., vol.47, no.48, pp12795, 2011.12
A. Ikeda, R. Aono, N. Maekubo, S. Katao, J. Kikuchi, M. Akiyama
"Location of [60]fullerene incorporation in lipid membranes," Chem. Commun., vol.47, no.44, pp12095, Nov. 2011
A. Ikeda, K. Kiguchi, T. Shigematsu, K. Nobusawa, J. Kikuchi, M. Akiyama
"Near-full-length REV3L appears to be a scarce maternal factor in Xenopus laevis eggs that changes qualitatively in early embryonic development.l," DNA Repair, vol.9, no.1, pp90, Jan. 2010
Ogawara D, Muroya T, Yamauchi K, Iwamoto TA, Yagi Y, Yamashita Y, Waga S, Akiyama M, Maki H.
[ doi:10.1016/j.dnarep.2009.10.004 ]
"Identification of a novel L-Serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo," J. Biol. Chem, vol.284, no.49, pp34157, Dec. 2009
A. Bahtiar, T. Matsumoto, T. Nakamura, M. Akiyama, K. Yogo, N. Ishida-Kitagawa, T. Ogawa, T.Takeya
[ doi:10.1074/jbc.M109.058933 ]
"Photodynamic activity of C(70) caged within surface-cross-linked liposomes," Chem Asian J., vol.4, pp199, Jan. 2009
Ikeda A, Nagano M, Akiyama M, Matsumoto M, Ito S, Mukai M, Hashizume M, Kikuchi JI, Katagiri K, Ogawa T, Takeya T.
[ doi:10.1002/asia.200800271 ]
"Photodynamic activity of C(70) caged within surface-cross-linked liposomes," Chem Asian J., vol.4, pp199, Jan. 2009
Ikeda A, Nagano M, Akiyama M, Matsumoto M, Ito S, Mukai M, Hashizume M, Kikuchi JI, Katagiri K, Ogawa T, Takeya T.
[ doi:10.1002/asia.200800271 ]
"Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal," Molecular Microbiology, vol.70, no.3, pp608, Nov. 2008
Kaori Uchida, Asako Furukohri, Yutaka Shinozaki, Tetsuya Mori, Daichi Ogawara, Shigehiko Kanaya, Takehiko Nohmi, Hisaji Maki, Masahiro Akiyama
[ doi:10.1111/j.1365-2958.2008.06423.x ]
"Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal," Molecular Microbiology, vol.70, no.3, pp608, Nov. 2008
Kaori Uchida, Asako Furukohri, Yutaka Shinozaki, Tetsuya Mori, Daichi Ogawara, Shigehiko Kanaya, Takehiko Nohmi, Hisaji Maki, Masahiro Akiyama
[ doi:10.1111/j.1365-2958.2008.06423.x ]
"Intracellular Uptake and Photodynamic Activity of Water-Soluble [60]- and [70]Fullerenes Incorporated in Liposomes," Chemistry, vol.14, pp8892, Aug. 2008
Doi Y, Ikeda A, Akiyama M, Nagano M, Shigematsu T, Ogawa T, Takeya T, Nagasaki T.
[ doi:10.1002/chem.200801090 ]
"Intracellular Uptake and Photodynamic Activity of Water-Soluble [60]- and [70]Fullerenes Incorporated in Liposomes," Chemistry, vol.14, pp8892, Aug. 2008
Doi Y, Ikeda A, Akiyama M, Nagano M, Shigematsu T, Ogawa T, Takeya T, Nagasaki T.
[ doi:10.1002/chem.200801090 ]
"Solubilization of [60] fullerenes using block copolymer and evaluation of their photodynamic activities," Org Biomol Chem, vol.in press, 2008
Akiyama, M, Ikeda, A, Shintani, T, Doi, Y, Kikuchi, J, Ogawa, T, Yogo, K, Takeya, T., Yamamoto, N.
[ doi:10.1039/b719671g ]
受賞
"日本遺伝学会 第86回大会 Best Papers 賞," 日本遺伝学会, 2014.12.24
古郡 麻子, 池田 美央, 西川 義人, 秋山 昌広, 片山 勉, Robert P. Fuchs, 真木 壽治
"日本遺伝学会 GGS prize 2013," 2013.9.20
池田美央, 篠崎 裕, 内田香里, 大鹿泰葉, 古郡 麻子, 眞木 壽治, 秋山 昌広
所属学協会
日本遺伝学会
日本分子生物学会
資料

小林 和夫

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 原核生物分子遺伝学

ゲノムの正確な複製がどのような仕組みに支えられているのか、あるいはこれとは逆に、ゲノムの不正確な複製によって引き起こされる突然変異や染色体異常はどのようなプロセスを経て発生するのかについて研究・教育を行う。