研究キーワード
 枯草菌, バイオフィルム, DNAアレー解析, 鞭毛形成, 転写制御, バイオフィル, 転写因子, DNAアレー, Plant-microbe, Bacillus subtilis, 転写, 糖代謝, 形態形成, 野生株, 鞭毛形, 酵母2ハイブリッド系, 蛋白質相互作用, 細胞システム, DnaA, 大腸菌, FISH, 蛋白質複合体, 染色体分配, レプリゾーム, 質量分析法, 複製開始複合体, GFP, Spo0J蛋白質, フローサイトメトリー, DNAヘリカーゼ
研究分野
 ライフサイエンス / システムゲノム科学 / , ライフサイエンス / ゲノム生物学 / , ライフサイエンス / 応用微生物学 / , ライフサイエンス / 細胞生物学 /
研究室概要
 ゲノムの正確な複製がどのような仕組みに支えられているのか、あるいはこれとは逆に、ゲノムの不正確な複製によって引き起こされる突然変異や染色体異常はどのようなプロセスを経て発生するのかについて研究・教育を行う。
学術論文
"Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms," PLoS Genetics, vol.17, no.17, ppe1009682, 21 Jul. 2021
Kazuo Kobayashi
[ doi:10.1371/journal.pgen.1009682 ]
"Calcium prevents biofilm dispersion in Bacillus subtilis," Journal of Bacteriology, vol.203, no.14, ppe00114-21, 1 Jul. 2021
Masaki Nishikawa, Kazuo Kobayashi
[ doi:10.1128/JB.00114-21 ]
"Role of Glutamate Synthase in Biofilm Formation by Bacillus subtilis," Journal of Bacteriology, vol.202, no.14, pp e00120-20, 25 Jun. 2020
Tan Kimura
[ doi:10.1128/JB.00120-20 ]
"Biofilm-associated toxin and extracellular protease cooperatively suppress competitors in Bacillus subtilis biofilms," Plos Genetics, Oct. 2019
Kazuo Kobayashi, Yukako Ikemoto
"Inactivation of cysL Inhibits Biofilm Formation by Activating the Disulfide Stress Regulator Spx in Bacillus subtilis.," Journal of Bacteriology, vol.201, no.8, ppe00712-18, 26 Mar. 2019
Kazuo Kobayashi
[ doi:10.1007/s00294-019-00950-6 ]
"Genetic analysis of collective motility of Paenibacillu sp. NAIST15-1," Plos genetics, Oct. 2016
小林　和夫, Yu Kanesaki, Hirofumi Yoshikawa
"Plant methyl salicylate induces defense responses in the rhizobacterium Bacillus subtilis," Environmental Microbiology, vol.17, no.4, pp1365-1376, Apr. 2015
Kazuo Kobayashi
"Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice.," Mol Brain, vol.5, no.1, pp43, Dec. 2012
Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, Tamura H, Shiosaka S, Suzuki H, Miyakawa T, Fujiyoshi Y, Doi T.
"BslA(YuaB) forms a hydrophobic layer on the surface of Bacillus subtilis biofilms.," Mol Microbiol., vol.85, no.1, pp51, Jul. 2012
Kobayashi K, Iwano M.
"Identifying valence band structure of transient phase in VO2 thin film by hard x-ray photoemission," Phys. Rev. B, vol.84, pp085107, Dec. 2011
T. Kanki, H. Takami, S. Ueda, A.N. Hattori, K. Hattori, H. Daimon, K. Kobayashi, H. Tanaka
"Mutations in MYB3R1 and MYB3R4 cause pleiotropic developmental defects and preferential down-regulation of multiple G2/M-specific genes in Arabidopsis thaliana.," Plant Physiol. in press, Aug. 2011
Haga, N, Kobayashi, K, Suzuki, T, Maeo, K, Kubo, M, Ohtani, M, Mitsuda, N, Demura, T, Nakamura, K, Jürgens, G., Ito, M.
"Repression of sigK Intervening (skin) Element Gene Expression by the CI-Like Protein SknR and Effect of SknR Depletion on Growth of Bacillus subtilis Cells," J Bacteriol, vol.192, no.23, pp6209, Dec. 2010
Kimura T, Amaya Y, Kobayashi K, Ogasawara N, Sato T
[ doi:10.1128/JB.00625-10 ]
"Repression of sigK intervening (skin) element gene expression by the CI-like protein SknR and effect of SknR depletion on growth of Bacillus subtilis cells.," J Bacteriol, vol.192, no.23, pp6209-6216, Dec. 2010
Kimura T, Amaya Y, Kazuo Kobayashi, Naotake Ogasawara, Sato T
"1.The paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis.," Journal of Bacteriology, vol.192, pp4571-4581, Sep. 2010
Chi BK, Kazuo Kobayashi, Albrecht D, Hecker M, Antelmann H
"The paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis.," J Bacteriol, vol.192, no.18, pp4571-4581, 2010.9
Chi BK, Kobayashi K, Albrecht D, Hecker M, Antelmann H.
"Transcriptional regulation of the Bacillus subtilis asnH operon and role of the 5'-proximal long sequence triplication in RNA stabilization.," Microbiology, vol.156, no.6, pp1632-1641, 2010.6
Morinaga T, Kobayashi K, Ashida H, Fujita Y, Yoshida K.
"2.Transcriptional regulation of the Bacillus subtilis asnH operon and role of the 5'-proximal long sequence triplication in RNA stabilization.," Microbiology, vol.156, pp1632-1641, Jan. 2010
Morinaga T, Kazuo Kobayashi, Ashida H, Fujita Y, Yoshida K
"A constrained Gaussian mixture model forcorrelation-based cluster analysis of gene expression data.," IPSJ Transactions on Bioinformatics, vol.2, pp47-62, May. 2009
Yukinawa, N., Yoshioka, T., Kazuo Kobayashi, Naotake Ogasawara, Ishii, S.
"SlrR/SlrA controls the initiation of biofilm formation in Bacillus subtilis.," Mol Microbiol, vol.69, no.6, pp1399, Sep. 2008
Kobayashi K
[ doi:10.1111/j.1365-2958.2008.06369.x ]
"SlrR/SlrA controls the initiation of biofilm formation in Bacillus subtilis.," Mol Microbiol, vol.69, no.6, pp1399-1410, Sep. 2008
Kazuo Kobayashi
"kinA mRNA is missing a stop codon in the undomesticated Bacillus subtilis strain ATCC 6051.," Microbiology, vol.154, no.1, pp54, Jan. 2008
Kobayashi K, Kuwana R, Takamatsu H.
[ doi:10.1099/mic.0.2007/011783-0 ]
"kinA mRNA is missing a stop codon in the undomesticated Bacillus subtilis strain ATCC 6051.," Microbiology, vol.154, no.1, pp54-63, Jan. 2008
Kobayashi K, Kuwana R, Takamatsu H.
"Gradual activation of the response regulator DegU controls serial expression of genes for flagellum formation and biofilm formation in Bacillus subtilis.," Mol Microbiol, vol.66, no.2, pp395, Oct. 2007
Kobayashi K
[ doi:10.1111/j.1365-2958.2007.05923.x ]
"The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis.," Mol Microbiol, vol.66, no.1, pp40, Oct. 2007
Towe S, Leelakriangsak M, Kobayashi K, Van Duy N, Hecker M, Zuber P, Antelmann H.
[ doi:10.1111/j.1365-2958.2007.05891.x ]
"The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis.," Mol Microbiol, vol.66, no.1, pp40-57, 2007.10
Töwe S, Leelakriangsak M, Kobayashi K, Van Duy N, Hecker M, Zuber P, Antelmann H.
"Gradual activation of the response regulator DegU controls serial expression of genes for flagellum formation and biofilm formation in Bacillus subtilis.," Mol Microbiol, vol.66, no.2, pp395-409, Oct. 2007
Kazuo Kobayashi
"Bacillus subtilis pellicle formation proceeds through genetically defined morphological changes.," J Bacteriol, vol.189, no.13, pp4920-4931, Jul. 2007
Kazuo Kobayashi
"The entire organization of transcription units on the Bacillus subilis genome," BMC Genomics, vol.8, pp197.1, 28 Jun. 2007
Hirokazu Kobayashi, Joe Akitomi, Nobuyuki Fujii, Md.Altaf-Ul-Amin, Kazuo Kobayashi, Ken Kurokawa, Naotake Ogasawara, Shigehiko Kanaya
"Dual negative control of spx transcription initiation from the P3 promoter by repressors PerR and YodB in Bacillus subtilis.," J Bacteriol, vol.189, no.5, pp1736-1744, Mar. 2007
Leelakriangsak M, Kobayashi K, Zuber P.
" Characterization of relationships between transcriptional units and operon structures in Bacillus subtilis and Escherichia coli," BMC Genomics, vol.8, no.1, pp48, Feb. 2007
Okuda, S., Kawashima, S., Kobayashi, K., Ogasawara, N., Kanehisa, M., Goto, S.
"Characterization of relationships between transcriptional units and operon structures in Bacillus subtilis and Escherichia coli.," BMC Genomics, vol.8, pp43, Feb. 2007
Okuda S, Kawashima S, Kobayashi K, Naotake Ogasawara, Kanehisa M, Goto S.
"Bacillus subtilis pellicle formation proceeds through genetically defined morphological changes.," J Bacteriol, vol.189, no.13, pp4920, Jan. 2007
Kobayashi K
[ doi:10.1128/JB.00157-07 ]
受賞
所属学協会
資料
他の研究者

秋山　昌広

職位 准教授
領域 バイオサイエンス領域 統合システム生物学分野
研究室 原核生物分子遺伝学

ゲノムの正確な複製がどのような仕組みに支えられているのか、あるいはこれとは逆に、ゲノムの不正確な複製によって引き起こされる突然変異や染色体異常はどのようなプロセスを経て発生するのかについて研究・教育を行う。