別所 康全

所属 バイオサイエンス領域 統合システム生物学分野
職位 教授
学位
研究室 遺伝子発現制御
研究キーワード
体節, 分節化, ゼブラフィッシュ, マウス, パターン形成, 転写因子, 生物時計, 発生生物学, 分子生物学
研究分野
ライフサイエンス / 生理学 / , ライフサイエンス / 発生生物学 / , ライフサイエンス / 病態医化学 / , ライフサイエンス / システムゲノム科学 / , ライフサイエンス / 医化学 /
研究室概要
せきつい動物発生の過程で起こるダイナミックな現象の動作原理を解明することを目的とした研究・教育を行う。
学術論文
"Zbtb38 inhibits apoptosis by transcriptionally regulating XIAP expression," bioRxiv, 5 Sep. 2024
Eishou Matsuda, SHIGEOKA Toshiaki, Hiroyuki Nagaoka, Nunuk Aries Nurulita, Shogo Tada
[ doi:10.1101/2024.09.05.611337 ]
"Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration," Cellular and Molecular Life Sciences, vol.81, pp51, 22 Jan. 2024
Naoya Shigesada, Naoya Shikada, Manabu Shirai, Michinori Toriyama, Fumiaki Higashijima, Kazuhiro Kimura, Toru Kondo, Yasumasa Bessho, Takuma Shinozuka, Noriaki Sasai
[ NAISTレポジトリ ] [ doi:10.1007/s00018-023-05087-x ]
"Interplay between HTRA1 and classical signalling pathways in organogenesis and diseases," Saudi Journal of Biological Sciences, vol.29, no.4, pp1919-1927, 1 Apr. 2022
Chio Oka, Razwa Saleh, Yasumasa Bessho, Hasan Mahmud Reza
[ doi:10.1016/j.sjbs.2021.11.056 ]
"Ultrasmall compact CMOS imaging system for bioluminescence reporter-based live gene expression analysis," Journal of Biomedical Optics, vol.26, pp116002, 3 Nov. 2021
Joshua Philippe Olorocisimo, Jeric Briones, Kiyotaka Sasagawa, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Norihiro Ishida-Kitagawa, Yasumasa Bessho, Jun Ohta
[ doi:10.1117/1.JBO.26.11.116002 ]
"The FGF-AKT pathway is necessary for cardiomyocyte survival for heart regeneration in zebrafish ," Developmental Biology, vol.472, pp30-37, Apr. 2021
Naoyuki Tahara, Ryutaro Akiyama, Justin Wang, Hiroko Kawakami, Yasumasa Bessho, Yasuhiko Kawakami
[ doi:10.1016/j.ydbio.2020.12.019 ]
"Pulsed laser activated impulse response encoder (PLAIRE): sensitive evaluation of surface cellular stiffness on zebrafish embryos," Biomedical Optics Express, vol.12, pp1366-1374, 1 Mar. 2021
Ryohei Yasukuni, Daiki Minamino, Takanori Iino, Takashi Araki, Kohei Takao, Sohei Yamada, Yasumasa Bessho, Takaaki Matsui, Yoichiroh Hosokawa
[ doi:10.1364/BOE.414338 ]
"Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases," Frontiers in Neuroscience, vol.15, Jan. 2021
Ahmed Rezwana, Yasukazu Nakahata, Kazuyuki Shinohara, Yasumasa Bessho
"Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer," Int. J. Mol. Sci., no.21, pp5962, 30 Aug. 2020
Takashi Shiromizu, Mizuki Yuge, Kousuke Kasahara, Daishi Yamakawa, Takaaki Matsui, Yasumasa Bessho, Masaki Inagaki, Yuhei Nishimura
"Over‐expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress‐induced premature senescence," Genes to Cells, vol.25, no.8, pp593-602, 13 Jun. 2020
Ardaning Nuriliani, Yasukazu Nakahata, Rezwana Ahmed, Fiqri D. Khaidizar, Takaaki Matsui, Yasumasa Bessho
"Relationship between surrounding tissue morphology and directional collective migration of the posterior lateral line primordium in zebrafish," Genes to Cell, 9 Jun. 2020
Akari Karaiwa, Sohei Yamada, Hodaka Yamamoto, Mizuho Wakasa, Hannosuke Ishijima, Ryotaro Akiyama, Yoichiroh Hosokawa, Yasumasa Bessho, Takaaki Matsui
[ doi:10.1111/gtc.12793 ]
"Relationship between surrounding tissue morphology and directional collective migration of the posterior lateral line primordium in zebrafish," Genes to Cells, vol.25, no.8, pp582-592, 9 Jun. 2020
Akari Karaiwa, Sohei Yamada, Hodaka Yamamoto, Mizuho Wakasa, Hannosuke Ishijima, Ryutaro Akiyama, Yoichiroh Hosokawa, Yasumasa Bessho, Takaaki Matsui
"Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system," Scientific Reports, vol.9, no.12156, 21 Aug. 2019
Urasaki A, Morishita S, Naka K, Uozumi M, Abe K, Huang L, Watase E, Nakagawa O, Kawakami K, Matsui T, Bessho Y, Inagaki N
[ NAISTレポジトリ ]
"Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time," AGING, vol.11, 9 Feb. 2019
Rezwana Ahmed, Atsushige Ashimori, Satoshi Iwamoto, Takaaki Matsui, Yasukazu Nakahata, Yasumasa Bessho
[ doi:10.18632/aging.101794 ]
"Noise-resistant developmental reproducibility in vertebrate somite formation," PLoS Comput Biol , vol.15, no.2, 4 Feb. 2019
Honda Naoki, Ryutaro Akiyama, Dini Wahyu Kartika Sari, Shin Ishii, Yasumasa Bessho, Takaaki Matsui
[ NAISTレポジトリ ] [ doi:10.1371/journal.pcbi.1006579 ]
"ERK Activity Dynamics during Zebrafish Embryonic Development.," International Journal of Molecular Sciences, vol.20, no.1, pp109, 28 Dec. 2018
Kah-Loon Wong, Ryutaro Akiyama, Yasumasa Bessho, Takaaki Matsui
[ NAISTレポジトリ ]
"Pulsed-laser-activated impulse response encoder (PLAIRE): detection of core–shell structure of biomimetic micro gel-sphere," Applied Physics A, vol.124, pp594, 9 Aug. 2018
Ryohei Yasukuni, Daiki Minamino, Tei Watanabe, Sohei Yamada, Takanori Iino, Yasumasa Bessho, Takaaki Matsui, Yoichiroh Hosokawa
[ NAISTレポジトリ ]
"Presomitic mesoderm-specific expression of the transcriptional repressor Hes7 is controlled by E-box, T-box, and Notch signaling pathways.," The Journal of Biological Chemistry , vol.293, no.31, pp12167-12176, 2018.8.3
Hayashi S, Nakahata Y, Kohno K, Matsui T, Bessho Y.
[ doi:10.1074/jbc.RA118.003728 ]
"Size-reduced embryos reveal a gradient scaling based mechanism for zebrafish somite formation," Development, 16 May. 2018
Kana Ishimatu, Tom W. Hiscock, Zach M. Collins, Dini Wahyu Kartika Sari, Kenny Lischer, David L. Richmond, Yasumasa Bessho, Takaaki Matsui, Sean G. Megason
" Time-lapse observation of stepwise regression of Erk activity in zebrafish presomitic mesoderm.," Scientific Reports, vol.8, no.4335, 12 Mar. 2018
Sari DWK, Ryutaro Akiyama, Naoki H., Hannosuke Ishijima, Yasumasa Bessho, Takaaki Matsui
[ NAISTレポジトリ ] [ doi:10.1038/s41598-018-22619-9 ]
"フェムト秒レーザー誘起衝撃力を利用した細胞排除課程におけるアクトミオシンの収縮力の測定," 電気学会研究会資料, vol.OQD-18-010~021, pp1-5, 2018.3.9
山田 壮平, 飯野敬矩, 別所 康全, 松井 貴輝, 細川陽一郎
"Bmal1-deficient mouse fibroblast cells do not provide premature cellular senescence in vitro," Chronobiology International, no.26, pp1-9, 16 Jan. 2018
Yasukazu Nakahata, Shiori Yasukawa, Fiqri Dizar Khaidizar, Shigeki Shimba, Takaaki Matsui, Yasumasa Bessho
"Noise-resistant developmental reproducibility in vertebrate somite formation," bioRxiv, 15 Jan. 2018
Naoki Honda, Ryutaro Akiyama, Shin Ishii, Yasumasa Bessho, Takaaki Matsui
"Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells," Genes to Cells, vol.22, pp982-992, 11 Oct. 2017
Fiqri Dizar Khaidizar, Yasukazu Nakahata, Akira Kume, Kyosuke Sumizawa, Kenji Kohno, Takaaki Matsui, Yasumasa Bessho
"Quantitative analysis of mechanical force required for cell extrusion in zebrafish embryonic epithelia," Biology Open , 7 Sep. 2017
Sohei Yamada, Takanori Iino, Yasumasa Bessho, Yoichiroh Hosokawa, Takaaki Matsui
"The circadian NAD+ metabolism: Impact on chromatin remodeling and aging. ," BioMed Research International, vol.10, no.1155, pp3208429, 5 Dec. 2016
Yasukazu Nakahata, Yasumasa Bessho
"Cell collectivity regulation within migrating cell cluster during Kupffer's vesicle formation in zebrafish," frontiers in Cell and Developmental Biology, vol.3, pp27, 7 Mar. 2015
Takaaki Matsui, Hiroshi Ishikawa, Yasumasa Bessho
"Hes7 3'UTR is required for somite segmentation function.," Scientific Reports, vol.4, pp6462-6462, 24 Sep. 2014
Fujimuro T, Matsui T, Nitanda Y, Matta T, Sakumura Y, Saito M, Kohno K, Nakahata Y, Bessho Y
"An anterior limit of FGF/Erk signal activity marks the earliest future somite boundary in zebrafish.," Development, vol.141, no.10, pp1104-1109, 2014.3.1
Ryutaro Akiyama, Miwa Masuda, Shoichiro Tsuge, Yasumasa Bessho, Takaaki Matsui
[ doi:10.1242/dev.098905 ]
"Retinoic acid controls proper head-to-trunk linkage in zebrafish by regulating an anterior-posterior somitogenetic rate d," Development, vol.141, no.1, pp158-165, 1 Jan. 2014
Bambang Retnoaji, Ryutaro Akiyama, Tatsuro Matta, Yasumasa Bessho, Takaaki Matsui
[ doi:10.1242/dev.097568 ]
"3'-UTR-dependent regulation of mRNA turnover is critical for differential distribution patterns of cyclic gene mRNAs.," FEBS J., vol.281, no.1, pp146-156, Jan. 2014
Nitanda Y, Matsui T, Matta T, Higami A, Kenji Kohno, Nakahata Y, Bessho Y.
[ doi:10.1111/febs.25582 ]
"Celf1 is required for formation of endoderm-derived organs in zebrafish," Int. J. Mol. Sci., vol.14, no.9, pp18009-18023, 3 Sep. 2013
Naoyuki Tahara, Yasumasa Bessho, Takaaki Matsui
[ NAISTレポジトリ ] [ doi:10.3390/ijms140918009 ]
"Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice.," J Physiol., vol.591, pp1749-1769, 1 Apr. 2013
Nakashima N, Ishii TM, Yasumasa Bessho, Kageyama R, Ohmori H
[ doi:10.1113/jphysiol.2012.247361 ]
"Celf1 regulation of dmrt2a is required for somite symmetry and left-right patterning during zebrafish development.," Development, vol.139, no.19, pp3553, Oct. 2012
Matsui T, Sasaki A, Akazawa N, Otani H, Bessho Y.
"Left-right asymmetry in zebrafish.," Cell Mol Life Sci., vol.69, no.18, pp3069-3077, Sep. 2012
Takaaki Matsui, Yasumasa Bessho
[ doi:10.1007/s00018-012-0985-6 ]
"The period of the somite segmentation clock is sensitive to Notch activity.," Mol. Biol. Cell,, vol.22, no.18, pp3541, Jun. 2012
Kim, W, Matsui, T, Yamao, M, Ishibashi, M, Tamada, K, Takumi, T, Kohno, K, Oba, S, Ihii, S, Sakumura, Y, Bessho, Y.
"Canopy1を介したFGFシグナルの活性制御機構," 細胞工学, vol.31, no.4, pp416, 2012.4
松井貴輝, 岡本 仁, 別所康全
"Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer’s vesicle organogenesis," PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol.108, no.24, pp9881, 2011.6
Matsui T, Thitamadee S, Murata T, Kakinuma H, Nabetani T, Hirabayashi Y, Hirate Y, Okamoto H, Bessho Y
"The period of the somite segmentation clock is sensitive to Notch activity," Molecular Biology of the Cell, vol.22, no.18, pp3541, 2011
Kim W, Matsui T, Yamao M, Ishibashi M, Tamada K, Takumi T, KohnoK, Oba S, Ishii S, Sakumura Y, Bessho Y,
"Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites," PLoS Genet, vol.5, no.9, ppe1000662, Sep. 2009
Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa JL, Maroto M
[ doi:10.1371/journal.pgen.1000662 ]
"Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites," PLoS Genet, vol.5, no.9, ppe1000662, Sep. 2009
Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa JL, Maroto M
[ doi:10.1371/journal.pgen.1000662 ]
"Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM.," PLoS ONE, vol.4, no.5, ppe5603, May. 2009
Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y.
[ doi:10.1371/journal.pone.0005603 ]
"Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM.," PLoS ONE, vol.4, no.5, ppe5603, May. 2009
Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y.
[ doi:10.1371/journal.pone.0005603 ]
"形作りを制御する生物時計としての分子振動," 細胞工学, vol.7, no.26, pp755, 2007.6
別所康全
"形作りを制御する生物時計としての分子振動," 細胞工学, vol.7, no.26, pp755, 2007.6
別所康全
"Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.," Proteins, vol.67, no.3, pp732-742, 15 May. 2007
Arai R, Ito K, Ohnishi T, Ohba H, Akasaka R, Bessho Y, Hanawa-Suetsugu K, Yoshikawa T, Shirouzu M, Yokoyama S
"遺伝子発現の振動が制御する生物の形づくり," システム/制御/情報, vol.51, pp493, 2007
別所康全
"遺伝子発現の振動が制御する生物の形づくり," システム/制御/情報, vol.51, pp493, 2007
別所康全
受賞
"優秀ポスター賞," 日本時間生物学会, 12 Nov. 2016
芦森温茂, Yasukazu Nakahata, Takaaki Matsui, Yasumasa Bessho
"ポスター賞," International Symposium on Biological Rhythms (JSC国際シンポジウム), 2016.11.11
芦森温茂, 中畑 泰和, 松井 貴輝, 別所 康全
所属学協会
日本発生学会
日本分子生物学会
日本生化学会
資料

松井 貴輝

職位 准教授
領域 バイオサイエンス領域 統合システム生物学分野
研究室 遺伝子発現制御

せきつい動物発生の過程で起こるダイナミックな現象の動作原理を解明することを目的とした研究・教育を行う。

北川 教弘

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 遺伝子発現制御

せきつい動物発生の過程で起こるダイナミックな現象の動作原理を解明することを目的とした研究・教育を行う。

秋山 隆太郎

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 遺伝子発現制御

せきつい動物発生の過程で起こるダイナミックな現象の動作原理を解明することを目的とした研究・教育を行う。

稲葉 泰子

職位 助教
領域 バイオサイエンス領域 統合システム生物学分野
研究室 遺伝子発現制御

せきつい動物発生の過程で起こるダイナミックな現象の動作原理を解明することを目的とした研究・教育を行う。