学術論文 |
- "Blastocyst complementation-based rat-derived heart generation reveals cardiac anomaly barriers to interspecies chimera development," iScience, vol.27, no.111414, Nov. 2024
- Yuri S, Arisawa N, Kitamuro K, Isotani A.
 [ doi:10.1016/j.isci.2024.111414. ]
- "Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte," Cellular and Molecular Neurobiology , vol.44, no.48, 1 Jun. 2024
- Nor Atiqah Muhamad, Kohei Masutani, Shota Furukawa, Shunsuke Yuri, Michinori Toriyama, Chuya Matsumoto, Seiya Itoh, Yuichiro Shinagawa, Ayako Isotani, Manami Toriyama, Hiroshi Itoh
- "Generating an organ-deficient animal model using a multi-targeted CRISPR-Cas9 system," Scientific Reports, vol.14, no.1, pp10636, May. 2024
- Lim JJ, Murata Y, Yuri S, Kitamuro K, Kawai T, Isotani A.
[ doi:10.1038/s41598-024-61167-3. ]
- "Generation of rat-derived lung epithelial cells in Fgfr2b-deficient mice retains species-specific development," Development , vol.151, no.1, ppdev202081, 5 Jan. 2024
- Shunsuke Yuri, Yuki Murase, Ayako Isotani
[ doi:10.1242/dev.202081 ]
- " Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification," iScience, vol.26, pp107887, 7 Sep. 2023
- Agnes Ong Lee Chen, Toshiya Kokaji, Arisa Kishi, Yoshihiro Takihara, Takuma Shinozuka, Ren Shimamoto, Ayako Isotani, Manabu Shirai, Noriaki Sasai
 [ NAISTレポジトリ ]
- "Scheduled simple production method of pseudopregnant female mice for embryo transfer using the luteinizing hormone-releasing hormone agonist," Scientific Reports, vol.12, no.1, pp21985, Dec. 2022
- Gema Puspa Sari, Patrick Louis Lagman Hilario, Shunsuke Yuri, Arata Honda, Ayako Isotani
[ doi:10.1038/s41598-022-26425-2. ]
- "Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung," Cell Rep, vol.41, no.11, pp111828, Dec. 2022
- Takumi Kawasaki, Moe Ikegawa, Kosuke Yunoki, Hifumi Otani, Daisuke Ori, Ken J Ishii, Kuroda Etsushi, Takamura Shiki, Kitabatake Masahiro, Ito Toshihiro, Ayako Isotani, Taro Kawai
[ doi:10.1016/j.celrep.2022.111828 ]
- "Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats," frontiers in Cell and Developmental Biology, vol.9, Feb. 2022
- Takafumi Matsumura, Taichi Noda, Yuhkoh Satouh, Akane Morohoshi, Shunsuke Yuri, Masaki Ogawa, Yonggang Lu, Ayako Isotani, Masahito Ikawa.
[ doi:10.3389/fcell.2021.810118. eCollection 2021. ]
- "Generation of rat lungs by blastocyst complementation in Fgfr2b-deficient mouse model," Biorxiv, 2022.1.6
- 由利 俊祐, 村瀬 勇気, 磯谷 綾子
[ doi:10.1101/2022.01.05.475149 ]
- "Generation of the Y-chromosome linked red fluorescent protein transgenic mouse model and sexing at the preimplantation stage," Experimantal Animals, 20 Sep. 2021
- Hirata Wataru, Taiki Tomoda, Shunsuke Yuri, Ayako Isotani
[ doi:10.1538/expanim.21-0119. ]
- "Intergenerational effect of short-term spaceflight in mice," iScience, vol.24, no.7, pp102773, Jun. 2021
- Keisuke Yoshida, Shin-Ichiro Fujita, Ayako Isotani, Takashi Kudo, Satoru Takahashi, Masahito Ikawa, Dai Shiba, Masaki Shirakawa, Masafumi Muratani, Shunsuke Ishii
[ doi:10.1016/j.isci.2021.102773. ]
- "A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame‑shift mutant models," Scientific reports, vol.11, no.8297, 15 Apr. 2021
- Yuki Kishimoto, Iori Nishiura, Wataru Hirata, Shunsuke Yuri, Nami Yamamoto, Masahito Ikawa, Ayako Isotani
[ doi:10.1038/s41598-021-87751-5 ]
- "Identification and characterization of the antigen recognized by the germ cell mAb TRA98 using a human comprehensive wet protein array," Genes to Cells, vol.Mar;26, no.3, pp180-189, Mar. 2021
- Eriko Fukuda, Hiromitsu Tanaka, Kei Yamaguchi, Mieko Takasaka, Yoshifumi Kawamura, Hidenobu Okuda, Ayako Isotani, Masahito Ikawa, Virginia Smith Shapiro, Junji Tsuchida, Yuki Okada, Akira Tsujimura, Yasushi Miyagawa, Shinichiro Fukuhara, Yoshitaka Kawakami, Morimasa Wada, Yoshitake Nishimune, Naoki Goshima
[ doi:10.1111/gtc.12832. ]
- "Diphtheria toxin-mediated transposon-driven poly (A)-trapping efficiently disrupts transcriptionally silent genes in embryonic stem cells. ," Genesis, Jun. 2020
- Yasumasa Ishida, Jie Bai, Ayako Isotani, Masashi Kawaichi, Ryohei Kondo, N. Ika Mayasari, Toshiaki Shigeoka, Masahito Ikawa, Goro Sashida
[ NAISTレポジトリ ]
- "Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice," Biology of Reproduction, vol.102, no.4, pp975-983, Apr. 2020
- Asami Oji, Ayako Isotani, Yoshitaka Fujihara, Julio M Castaneda, Seiya Oura, Masahito Ikawa
[ doi:10.1093/biolre/ioaa002. ]
- "Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice," Neuroscience Research, vol.S0168-0102, no.20 , pp30212, Apr. 2020
- Chih-Yao Liu, Chia-Jung Tsai, Shinnosuke Yasugaki, Nanae Nagata, Miho Morita, Ayako Isotani, Masashi Yanagisawa, Yu Hayashi
[ doi:10.1016/j.neures.2020.04.002. ]
- "Hereditary Pancreatitis Model by Blastocyst Complementation in Mouse.," Oncotarget, Apr. 2020
- Asai A, Konno M, Koseki J, Kawamoto K, Isotani A, Mori M, Eguchi H, Doki Y, Arai T, Ishii H
- "Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers.," Development, vol.146, no.21, Nov. 2019
- Serizawa T, Isotani A, Matsumura T, Nakanishi K, Nonaka S, Shibata S, Ikawa M, Okano H
[ doi:10.1242/dev.174938. ]
- "Male mice, caged in the International Space Station for 35 days, sire healthy offspring.," Scientific Reports, vol.9, no.1, pp13733, Sep. 2019
- Matsumura T, Noda T, Muratani M, Okada R, Yamane M, Isotani A, Kudo T, Takahashi S, Ikawa M
[ doi:10.1038/s41598-019-50128-w. ]
- "CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice.," Biology of Reproduction, vol.101, no.2, pp501-511, Aug. 2019
- Lu Y, Oura S, Matsumura T, Oji A Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D Zhang Q, Larasati T, Young SAM, Kodani M, Huddleston CA, Robertson MJ, Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX, Ikawa M
[ doi:10.1093/biolre/ioz103. ]
- "An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility.," Journal of Reproduction and Development, vol.65, no.2, pp121-128, 12 Apr. 2019
- Takafumi Matsumura, Tsutomu Endo, Ayako Isotani, Masaki Ogawa, Masahito Ikawa
[ doi:10.1262/jrd.2018-145. ]
- "Chimeric analysis with newly established EGFP/DsRed2-tagged ES cells identify HYDIN as essential for spermiogenesis in mice.," Experimental Animals, 9 Aug. 2018
- Oura S, Miyata H, Noda T, Shimada K, Matsumura T, Morohoshi A, Isotani A, Ikawa M.
- "Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism.," EMBO Reports, pppii: e44860, Mar. 2018
- Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani Y, Shintani N, Hashimoto H
- "A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats.," Biology of Reproduction, Jun. 2017
- Isotani A, Matsumura T, Ogawa M, Tanaka T, Yamagata K, Ikawa M, Okabe M
- "Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis," Cell Reports, vol.18, no.3, pp593-600, Feb. 2017
- Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H, Yamagata K.
[ doi:10.1016/j.celrep.2016.12.065 ]
- "CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice," Scientific Reports, vol.6, no.31666, Aug. 2016
- Oji A, Noda T, Fujihara Y, Miyata H, Kim YJ, Muto M, Nozawa K, Matsumura T, Isotani A, Ikawa M.
[ doi:10.1038/srep31666 ]
- "Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice," Proc Natl Acad Sci U S A. , vol.113, no.28, pp7704-7710, Jul. 2016
- Miyata H, Castaneda JM, Fujihara Y, Yu Z, Archambeault DR, Isotani A, Kiyozumi D, Kriseman ML, Mashiko D, Matsumura T, Matzuk RM, Mori M, Noda T, Oji A, Okabe M, Prunskaite-Hyyrylainen R, Ramirez-Solis R, Satouh Y, Zhang Q, Ikawa M, Matzuk MM.
[ doi:10.1073/pnas.1608458113 ]
- "Behavior of Mouse Spermatozoa in the Female Reproductive Tract from Soon after Mating to the Beginning of Fertilization," Biology of Reproduction, vol.94, no.4, pp80, Apr. 2016
- Muro Y, Hasuwa H, Isotani A, Miyata H, Yamagata K, Ikawa M, Yanagimachi R, Okabe M.
[ doi:10.1095/biolreprod.115 ]
- "Generation of Hprt-disrupted rat through mouse←rat ES chimeras.," Scientific Reports, Mar. 2016
- Isotani A, Yamagata K, Okabe M, Ikawa M
- "CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines identified Ccdc63 as Essential for Spermiogenesis," Int J Mol Sci. , vol.16, no.10, pp24732-24750, Oct. 2015
- Young SA, Miyata H, Satouh Y, Kato H, Nozawa K, Isotani A, Aitken RJ, Baker MA, Ikawa M.
- "Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive," Science, vol.350, no.6259, pp442-445, Oct. 2015
- Miyata H, Satouh Y, Mashiko D, Muto M, Nozawa K, Shiba K, Fujihara Y, Isotani A, Inaba K, Ikawa M.
[ doi:10.1126/science.aad0836 ]
- "Calreticulin is required for development of the cumulus oocyte complex and female fertility," Scientific Reports, vol.5, no.14254, Sep. 2015
- Tokuhiro K, Satouh Y, Nozawa K, Isotani A, Fujihara Y, Hirashima Y, Matsumura H, Takumi K, Miyano T, Okabe M, Benham AM, Ikawa M
[ doi:10.1038/srep14254 ]
- "One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT)," BMC Genomics, vol.16, no.274, Apr. 2015
- Ohtsuka M, Miura H, Mochida K, Hirose M, Hasegawa A, Ogura A, Mizutani R, Kimura M, Isotani A, Ikawa M, Sato M, Gurumurthy CB
[ doi:10.1186/s12864-015-1432-5 ]
- "Induction of Primordial Germ Cell-Like Cells from Mouse Embryonic Stem Cells by ERK Signal Inhibition," Stem Cells, vol.32, no.10, pp2668-2678, Oct. 2014
- Kimura T, Kaga Y, Ohta H, Odamoto M, Sekita Y, Li K, Yamano N, Fujikawa K, Isotani A, Sasaki N, Toyoda M, Hayashi K, Okabe M, Shinohara T, Saitou M, Nakano T.
[ doi:10.1002/stem.1781 ]
- "“ラット”って、どんな研究につかわれているの？～第7回ラットリソースリサーチ研究会," 実験医学, vol.32, no.8, pp1304-1306, 2014.5
- 磯谷 綾子
- "Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA," Scientific Reports, vol.3, no.3355, Nov. 2013
- Mashiko D, Fujihara Y, Satouh Y, Miyata H, Isotani A, Ikawa M
[ doi:10.1038/srep03355 ]
- "SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia.," Development, vol.139, pp3583-3589, Oct. 2012
- Fujihara Y, Satouh Y, Inoue N, Isotani A, Ikawa M, Okabe M
[ doi:10.1242/dev.081778 ]
- "A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.," Nature Methods, vol.8, pp1071-1077, Oct. 2011
- Horie K, Kokubu C, Yoshida J, Akagi K, Isotani A, Oshitani A, Yusa K, Ikeda R, Huang Y, Bradley A, Takeda J
[ doi:10.1038/nmeth.1739 ]
- "Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.," Genes to Cells, Mar. 2011
- Isotani A, Hatayama H, Kaseda K, Ikawa M, Okabe M
- "Placenta-specific gene activation and inactivation using integrase-defective lentiviral vectors with the Cre/LoxP system.," Genesis, vol.47, pp793-798, Dec. 2009
- Morioka Y, Isotani A, Oshima RG, Okabe M, Ikawa M.
[ doi:10.1002/dvg.20563 ]
- "OAZ-t/OAZ3 is essential for rigid connection of sperm tails to heads in mouse," PLoS Genetics, vol.5, ppe1000712, Nov. 2009
- Tokuhiro K, Isotani A, Yokota S, Yano Y, Oshio S, Hirose M, Wada M, Fujita K, Ogawa Y, Okabe M, Nishimune Y, Tanaka H
- " A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice.," Nature Genetics, vol.41, pp946-952, Aug. 2009
- Kokubu C, Horie K, Abe K, Ikeda R, Mizuno S, Uno Y, Ogiwara S, Ohtsuka M, Isotani A, Okabe M, Imai K, Takeda J
- "Disruption of ADAM3 impairs the migration of sperm into oviduct in mouse.," Biology of Reproduction, vol.81, pp142-146, Jul. 2009
- Yamaguchi R, Muro Y, Isotani A, Tokuhiro K, Takumi K, Adham I, Ikawa M, Okabe M.
[ doi:10.1095/biolreprod.108.074021 ]
- "Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis.," The Jounal of Biological Chemistry, vol.283, pp19039-19048, Jul. 2008
- Tokuhiro K, Hirose M, Miyagawa Y, Tsujimura A, Irie S, Isotani A, Okabe M, Toyama Y, Ito C, Toshimori K, Takeda K, Oshio S, Tainaka H, Tsuchida J, Okuyama A, Nishimune Y, Tanaka H
- "Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer.," Nature Biotechnology, vol.25, pp233-237, Feb. 2007
- Okada Y, Ueshin Y, Isotani A, Saito-Fujita T, Nakashima H, Kimura K, Mizoguchi A, Oh-Hora M, Mori Y, Ogata M, Oshima RG, Okabe M, Ikawa M
- "Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages. ," Current Biology, vol.16, pp166-172, Jan. 2006
- Kobayashi S, Isotani A, Mise N, Yamamoto M, Fujihara Y, Kaseda K, Nakanishi T, Ikawa M, Hamada H, Abe K, Okabe M
- "HANP1/H1T2, a novel histone H1-like protein involved in nuclear formation and sperm fertility.," Mollecular and cellular biology, vol.25, pp7107-7119, Aug. 2005
- Tanaka H, Iguchi N, Isotani A, Kitamura K, Toyama Y, Matsuoka Y, Onishi M, Masai K, Maekawa M, Toshimori K, Okabe M, Nishimune Y
- "Genomic imprinting of XX spermatogonia and XX oocytes recovered from XXXY chimeric testes.," Proceedings of the National Academy of Science of the United States of America, vol.102, pp4039-4044, Mar. 2005
- Isotani A, Nakanishi T, Kobayashi S, Lee J, Chuma S, Nakatsuji N, Ishino F, Okabe M
- "The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs.," Nature, vol.434, pp234-238, Mar. 2005
- Inoue N, Ikawa M, Isotani A, Okabe M
- "Selective passage through the uterotubal junction of sperm from a mixed population produced by chimeras of calmegin-knockout and wild-type male mice.," Biology of Reproduction, vol.71, pp959-965, Sep. 2004
- Nakanishi T, Isotani A, Yamaguchi R, Ikawa M, Baba T, Suarez SS, Okabe M
- "FISH analysis of 142 EGFP transgene integration sites into the mouse genome. ," Genomics, Dec. 2002
- Nakanishi T, Kuroiwa A, Yamada S, Isotani A, Yamashita A, Tairaka A, Hayashi T, Takagi T, Ikawa M, Matsuda Y, Okabe M
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