研究キーワード
眼科学, 神経発生学, 細胞生物学, 発生生物学
研究分野
ライフサイエンス / 細胞生物学 / 膜生物学, ライフサイエンス / 実験病理学 / 黄斑変性, ライフサイエンス / 発生生物学 / 神経発生学
研究室概要
中枢神経系の多様な神経細胞の産生と機能維持の分子機構を知ることを目標に、 神経細胞の発生における誘導因子と前駆細胞の反応性の関係を、ニワトリ、マウス胚をモデルとして分子レベルで明らかにするとともに、いったん産生された神経細胞の機能維持のメカニズムを解明する研究・ 教育を実施する。
学術論文
"The Transmembrane Protein TMEM196 controls cell proliferation and determines the floor plate cell lineage.," Development, Growth and Differentiation, 18 Jan. 2025
Takuma Shinozuka, Yuichi Sakumura, Noriaki Sasai
[ doi:10.1111/dgd.12960 ]
"脊髄の発生," 脊椎脊髄ジャーナル, vol.37, no.5, pp335-340, 2024.5
笹井 紀明
"Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration," Cellular and Molecular Life Sciences, vol.81, pp51, 22 Jan. 2024
Naoya Shigesada, Naoya Shikada, Manabu Shirai, Michinori Toriyama, Fumiaki Higashijima, Kazuhiro Kimura, Toru Kondo, Yasumasa Bessho, Takuma Shinozuka, Noriaki Sasai
[ NAISTレポジトリ ] [ doi:10.1007/s00018-023-05087-x ]
"Regulation of progenitor cell survival by a novel chromatin remodeling factor during neural tube development," Development, Growth and Differentiation, vol.66, pp89-100, 19 Dec. 2023
Noriaki Sasai, Shogo Tada, Jumi Ohshiro, Chikara Kogiso, Takuma Shinozuka
[ doi:10.1111/dgd.12905 ]
"Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos," Developmental Dynamics, 28 Sep. 2023
Takuma Shinozuka, Motoko Aoki, Yudai Hatakeyama, Noriaki Sasai, Hiroshi Okamoto, Shinji Takada
[ doi:10.1002/dvdy.659 ]
" Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification," iScience, vol.26, pp107887, 7 Sep. 2023
Agnes Ong Lee Chen, Toshiya Kokaji, Arisa Kishi, Yoshihiro Takihara, Takuma Shinozuka, Ren Shimamoto, Ayako Isotani, Manabu Shirai, Noriaki Sasai
[ NAISTレポジトリ ]
"Prominin‐1 deletion results in spermatogenic impairment, sperm morphological defects, and infertility in mice," Reproductive Medicine and Biology, vol.22, ppe12514, 2023.4.9
Haruka Matsukuma, Yuka Kobayashi, Shintaro Oka, Fumiaki Higashijima, Kazuhiro Kimura, Erika Yoshihara, 笹井 紀明, Koji Shiraishi
[ doi:10.1002/rmb2.12514 ]
"Manipulation of Signal Gradient and Transcription Factors Recapitulates Multiple Hypothalamic Identities," Stem Cells, vol.41, pp453-467, 2 Mar. 2023
Maho Yamamoto, Agnes Ong Lee Chen, Takuma Shinozuka, Manabu Shirai, Noriaki Sasai
[ doi:10.1093/stmcls/sxad018 ]
"The Rx transcription factor is required for determination of the retinal lineage and regulates the timing of neuronal differentiation," Development, Growth and Differentiation, 14 Jun. 2022
Maho Yamamoto, Agnes Ong Lee Chen, Takuma Shinozuka, Noriaki Sasai
[ NAISTレポジトリ ] [ doi:10.1111/dgd.12796 ]
"Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression," Cell proliferation, vol.55, no.4, pp1-14, 17 Mar. 2022
Miki Nishio, Takuya Matsuura, Shunya Hibi, Shiomi Ohta, Chio Oka, Noriaki Sasai, Yasumasa Ishida, Eishou Matsuda
[ doi:10.1111/cpr.13215 ]
"Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina," 19 Oct. 2021
Yuka Kobayashi, Shizuka Watanabe, Agnes Lee Chen Ong, Manabu Shirai, Chiemi Yamashiro, Tadahiko Ogata, Fumiaki Higashijima, Takuya Yoshimoto, Takahide Hayano, Yoshiyuki Asai, Noriaki Sasai, Kazuhiro Kimura
[ NAISTレポジトリ ] [ doi:10.1242/dmm.048962 ]
"Sox14 is essential for initiation of neuronal differentiation in the chick spinal cord," Developmental Dynamics, vol.Online ahead of print, 28 Jun. 2021
Taiki Katsuyama, Minori Kadoya, Manabu Shirai, Noriaki Sasai
[ NAISTレポジトリ ] [ doi:10.1002/dvdy.392 ]
"Sox14 is essential for initiation of interneuron differentiation in the chick spinal cord.," Research Square, 2021.2.22
Taiki Katsuyama, Minori Kadoya, Noriaki Sasai
[ NAISTレポジトリ ]
"Neural induction: Historical views and application to pluripotent stem cells," Development Growth and Differentiation, 2 Dec. 2020
Noriaki Sasai, Minori Kadoya, Agnes Ong Lee Chen
[ NAISTレポジトリ ] [ doi:10.1111/dgd.12703 ]
"脳の領域化," 脳科学辞典, 2020.9.14
笹井 紀明
"コーディン," 脳科学辞典, 2020.7.29
笹井 紀明
[ doi:10.14931/bsd.9269 ]
"Prominin-1 Modulates Rho/ROCK-Mediated Membrane Morphology and Calcium-Dependent Intracellular Chloride Flux," Scientific Reports, vol.9, no.15911, 4 Nov. 2019
Akiko Nishi, Kenji Nishide, Kei Haga, Wataru Kakuta, Yasuyuki Ishikawa, Matthew J. Hayes, Shin-ichi Ohnuma, Hiroshi Kiyonari, Kazuhiro Kimura, Toru Kondo, Noriaki Sasai
[ doi:10.1038/s41598-019-52040-9 ]
"Hedgehog signal and genetic disorders," Frontiers in Genetics, 12 Oct. 2019
Noriaki Sasai, Michinori Toriyama, Toru Kondo
[ NAISTレポジトリ ] [ doi:10.3389/fgene.2019.01103 ]
"Negative regulation of mTOR signalling restricts cell proliferation in the floor plate," Frontiers in Neuroscience , 25 Sep. 2019
Minori Kadoya, Noriaki Sasai
[ doi:10.3389/fnins.2019.01022 ]
" GPR17 is an Essential Regulator for the Temporal Adaptation of Sonic Hedgehog Signalling in Neural Tube Development ," Development, 23 Aug. 2019
Atsuki Yatsuzuka, Akiko Hori, Minori Kadoya, Mami Matsuo-Takasaki, Toru Kondo, Noriaki Sasai
[ NAISTレポジトリ ] [ doi:10.1242/dev.176784 ]
"RNF152 Negatively Regulates mTOR Signalling and Blocks Cell Proliferation in the Floor Plate," BioRxiv, 23 May. 2019
Minori Kadoya, Noriaki Sasai
[ NAISTレポジトリ ] [ doi:10.1101/646661 ]
"Membrane Protrusion Formation Mediated by Rho/ROCK Signalling and Modulation of Chloride Flux," bioRxiv, 5 Apr. 2019
Akiko Hori, Kenji Nishide, Yuki Yasukuni, Kei Haga, Wataru Kakuta, Yasuyuki Ishikawa, Matthew J Hayes, Shin-ichi Ohnuma, Hiroshi Kiyonari, Kazuhiro Kimura, Toru Kondo, Noriaki Sasai
[ doi:10.1101/600379 ]
"GPR17 is an essential component of the negative feedback loop of the Sonic Hedgehog signalling pathway in neural tube development.," BioRxiv, pp424598, 27 Sep. 2018
Atsuki Yatsuzuka, Akiko Nishi, Minori Kadoya, Mami Matsuo-Takasaki, Toru Kondo, Noriaki Sasai
[ doi:10.1101/424598 ]
"位置情報," 脳科学辞典, 2018.3.31
笹井 紀明
[ NAISTレポジトリ ]
"ソニック・ヘッジホッグ," 脳科学事典, 2017.5.8
笹井 紀明
[ NAISTレポジトリ ]
"神経誘導," 脳科学事典, 2017.4.23
笹井 紀明
[ NAISTレポジトリ ]
"MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus.," Biology Open, vol.5, no.11, pp1631-1641, 15 Nov. 2016
Vacca B, Sanchez-Heras E, Steed E, Balda MS, Ohnuma SI, Sasai N, Mayor R, Matter K.
[ NAISTレポジトリ ]
"Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs.," Developmental Cell, vol.36, no.6, pp639-653, 21 Mar. 2016
Kutejova E, Sasai N, Shah A, Gouti M, Briscoe J.
[ NAISTレポジトリ ]
"Autosomal-dominant corneal endothelial dystrophies CHED1 and PPCD1 are allelic disorders caused by non-coding mutations in the promoter of OVOL2," The American Journal of Human Genetics , vol.98, pp75-89, Jan. 2016
Alice E. Davidson, Petra Liskova, Cerys J. Evans, Lubica Dudakova, Lenka Nosková, Nikolas Pontikos, Hana Hartmannová, Kateřina Hodaňová, Viktor Stránecký, Zbyněk Kozmík, Hannah J. Levis, Nwamaka Idigo, Noriaki Sasai, Geoffrey J. Maher, James Bellingham, Neyme Veli, Neil D. Ebenezer, Michael E. Cheetham, Julie T. Daniels, Caroline M.H. Thaung, Katerina Jirsova, Vincent Plagnol, Martin Filipec, Stanislav Kmoch, Stephen J. Tuft, Alison J. Hardcastle
[ NAISTレポジトリ ]
"The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway," Development, vol.142, pp3351-3361, 1 Oct. 2015
Luehders K, Sasai N, Davaapil H, Kurosawa-Yoshida M, Hiura H, Brah T, Ohnuma SI
[ NAISTレポジトリ ]
受賞
所属学協会
資料

篠塚 琢磨

職位 助教
領域 バイオサイエンス領域 メディカル生物学分野
研究室 発生医科学

中枢神経系の多様な神経細胞の産生と機能維持の分子機構を知ることを目標に、 神経細胞の発生における誘導因子と前駆細胞の反応性の関係を、ニワトリ、マウス胚をモデルとして分子レベルで明らかにするとともに、いったん産生された神経細胞の機能維持のメカニズムを解明する研究・ 教育を実施する。