研究キーワード
研究分野
研究室概要
免疫応答の発動メカニズムやその破綻により引き起こされる自己免疫疾患、アレルギー、炎症性疾患などの発症メカニズムを理解するとともに、治療や診断法の開発を目指した研究・教育を行う。
学術論文
"HuR (ELAVL1) regulates the CCHFV minigenome and HAZV replication by associating with viral genomic RNA," PLOS Neglected Tropical Diseases, vol.18, ppe0012553, 30 Sep. 2024
Moe Ikegawa, Kano Norisuke, Daisuke Ori, Mizuki Fukuta, Minato Hirano, Roger Hewson, Kentaro Yoshii, Taro Kawai, Takumi Kawasaki
"Identification and characterization of putative enhancer regions that direct Il6 transcription in murine macrophages," Int Immunol, vol.dxae024, no.dxae024, ppdxae024, 22 Apr. 2024
加納 規資, Takeo Miki, Yurina Uehara, 織 大祐, 河合 太郎
[ doi:10.1093/intimm/dxae024 ]
"Decoding Toll-like receptors: Recent insights and perspectives in innate immunity," Immunity, vol.57, no.4, pp649-673, 9 Apr. 2024
Taro Kawai, Moe Ikegawa, Daisuke Ori, Shizuo Akira
[ doi:10.1016/j.immuni.2024.03.004 ]
"Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung," Cell Rep, vol.41, no.11, pp111828, Dec. 2022
Takumi Kawasaki, Moe Ikegawa, Kosuke Yunoki, Hifumi Otani, Daisuke Ori, Ken J Ishii, Kuroda Etsushi, Takamura Shiki, Kitabatake Masahiro, Ito Toshihiro, Ayako Isotani, Taro Kawai
[ doi:10.1016/j.celrep.2022.111828 ]
"Inhibition of lipopolysaccharide-induced inflammatory responses by 1'-acetoxychavicol acetate," Genes Cells, vol.27, no.7, pp482-492, 27 Jul. 2022
Guang Han Ong, Daisuke Ori, Takumi Kawasaki, Taro Kawai
[ doi:10.1111/gtc.12943 ]
"Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases," Front Cell Infect Microbiol, vol.12, pp910654, 6 Jul. 2022
Kano Norisuke, Guang Han Ong, Daisuke Ori, Taro Kawai
[ doi:10.3389/fcimb.2022.910654 ]
"Pathophysiological functions of self-derived DNA," Int Rev Immunol, pp1-13, 2 May. 2022
Daisuke Ori, Taro Kawai
[ NAISTレポジトリ ] [ doi:10.1080/08830185.2022.2070616 ]
"Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site," iScience, vol.25, no.4, pp104118, 18 Mar. 2022
Benedict Shi Xiang Lian, Takumi Kawasaki, Kano Norisuke, Daisuke Ori, Moe Ikegawa, Taro Kawai
[ doi:10.1016/j.isci.2022.104118 ]
"異所性DNAの認識機構と生体応答," 実験医学2022年3月号 特集「RNAワクチンの先の基礎研究〜核酸と生体防御のメカニズムを解き明かす」, vol.40, no.4, pp533-538, 2022.2
織 大祐, 河合 太郎
[ doi:10.18958/6991-00001-0000061-00 ]
"1'-acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression," International Immunology, vol.33, no.7, pp373-386, 18 Jun. 2021
Sophia P. M. Sok, Daisuke Ori, Ayana Wada, Haruna Okude, Takumi Kawasaki, Masatoshi Momota, Noor Hasima Nagoor, Taro Kawai
[ doi:10.1093/intimm/dxab016. ]
"Signaling through nucleic acid sensors and their roles in inflammatory diseases," Frontiers in Immunology, vol.11, pp625833, 28 Jan. 2021
Haruna Okude, Daisuke Ori, Taro Kawai
[ doi:10.3389/fimmu.2020.625833 ]
"The Ca2+-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-33," Biochemical and Biophysical Research Communications, Oct. 2020
Masatoshi Momota, Mizuka Nagayama, Haruna Okude, Ken J Ishii, Daisuke Ori, Takumi Kawasaki, Taro Kawai
[ doi:10.1016/j.bbrc.2020.07.127 ]
"Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses," Biochemical and Biophysical Research Communications, 22 Jan. 2020
Warunthorn Monwan, Takumi Kawasaki, Md Zobaer Hasan, Daisuke Ori, Taro Kawai
[ doi:10.1016/j.bbrc.2019.11.035 ]
"PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking," J Bio Chem, vol.294, pp8412-8423, 24 May. 2019
Putri DDP, Kawasaki T, Murase M, Sueyoshi T, Deguchi T, Ori D, Suetsugu S, Kawai T
[ doi:10.1074/jbc.RA118.005731. ]
"Sensing self and non-self DNA by innate immune receptors and their signaling pathways," Critical Reviews in Immunology, vol.38, no.4, pp279-301, Jul. 2018
Sophia P. M. Sok, Daisuke Ori, Noor Hasima Nagoor, Taro Kawai
[ doi:10.1615/CritRevImmunol.2018026540 ]
"Hu Antigen R regulates antiviral innate immune responses through the stabilization of mRNA for Polo-like kinase 2. ," The Journal of Immunology, vol.200, pp3814-3824, 1 Jun. 2018
Sueyoshi T, Kawasaki T, Kitai Y, Ori D, Akira S, Kawai T
[ doi:10.4049/jimmunol.1701282 ]
"Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs," Cell Reports, vol.19, no.8, pp1614-1630, Dec. 2017
Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi
[ doi:10.1016/j.celrep.2017.05.009 ]
"Cytosolic nucleic acid sensors and innate immune regulation," International Reviews of Immunology, vol.36, no.2, 23 Mar. 2017
Ori D, Murase M, Kawai T
[ doi:10.1080/08830185.2017.1298749 ]
"組織マクロファージの文化・活性化の分子機構," 炎症と免疫, vol.24, no.4, pp336-339, 2016.12
織大祐, 竹内理
"Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses," The Journal of Immunology, vol.195, no.2, pp519-527, Dec. 2015
Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Daisuke Ori, Takashi Mino, Osamu Takeuchi
[ doi:10.4049/jimmunol.1500373 ]
"Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms," Cell, vol.161, no.5, pp1058-1073, Dec. 2015
Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Dron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi
[ doi:10.1016/j.cell.2015.04.029 ]
"Negative regulation of MDA5-dependent antiviral innate responses by Arl-like protein 5B," The Journal of Biological Chemistry, vol.290, no.2, pp1269-1280, Dec. 2015
Yuichi Kitai, Osamu Takeuchi, Takumi Kawasaki, Daisuke Ori, Takuya Sueyoshi, Motoya Murase, Shizuo Akira, Taro Kawai
[ doi:10.1074/jbc.M114.611053 ]
"Akirin2 is critical for inducing inflammatory genes by bridging IkappaB-zeta and the SWI/SNF complex," The EMBO Journal, vol.33, no.20, pp2332-2348, Dec. 2014
Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M Standley, Jules A Hoffmann, Jean-Marc Reichhart, Shizuo Akira, Osamu Takeuchi
[ doi:10.15252/embj.201488447 ]
"Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation," The Journal of Immunology, vol.190, no.11, pp5702-5711, Dec. 2013
Masahiro Fukasaka, Daisuke Ori, Tatsukata Kawagoe, Satoshi Uematsu, Kenta Maruyama, Toshihiko Okazaki, Tatsuya Kozaki, Tomoko Imamura, Sarang Tartey, Takashi Mino, Takashi Satoh, Shizuo Akira, Osamu Takeuchi
[ doi:10.4049/jimmunol.1203155 ]
"Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs," The Journal of Immunology, vol.190, no.8, pp4037-4045, Dec. 2013
Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi
[ doi:10.4049/jimmunol.1300173 ]
"自然免疫と炎症制御の分子機構," 医薬ジャーナル, vol.49, no.2, pp651-656, 2013.12
織大祐, 竹内理
受賞
所属学協会
資料

河合 太郎

職位 教授
領域 バイオサイエンス領域 メディカル生物学分野
研究室 分子免疫制御

免疫応答の発動メカニズムやその破綻により引き起こされる自己免疫疾患、アレルギー、炎症性疾患などの発症メカニズムを理解するとともに、治療や診断法の開発を目指した研究・教育を行う。

加納 規資

職位 助教
領域 バイオサイエンス領域 メディカル生物学分野
研究室 分子免疫制御

免疫応答の発動メカニズムやその破綻により引き起こされる自己免疫疾患、アレルギー、炎症性疾患などの発症メカニズムを理解するとともに、治療や診断法の開発を目指した研究・教育を行う。