石田 靖雅

所属 バイオサイエンス領域 メディカル生物学分野
職位 准教授
学位
研究室 機能ゲノム医学
研究キーワード
がん免疫療法, 獲得免疫, Tリンパ球, 自己-非自己識別, PD-1
研究分野
ライフサイエンス / 免疫学 /
研究室概要
哺乳類細胞の細胞周期制御、細胞老化、細胞分化、アポトーシス、オートファジー、幹細胞制御などに興味を持ち、腫瘍細胞の増殖、分化、生存を制御する分子メカニズムに関する研究・教育を行う。
学術論文
"Zbtb38 transcriptionally activates XIAP to regulate apoptosis in development and cancer," Journal of Molecular Cell Biology, 17 Mar. 2026
Shigeoka Toshiaki, Hiroyuki Nagaoka, Nunuk Aries Nurulita, Shogo Tada, Yasumasa Bessho, Yasumasa Ishida
[ NAISTレポジトリ ] [ doi:10.1093/jmcb/mjag011 ]
"PD-1 is conserved from sharks to humans: new insights into PD-1, PD-L1, PD-L2, and SHP-2 evolution," Frontiers in Immunology, vol.Volume 16 , 28 May. 2025
Ryohei Kondo, Kohei Kondo, Kei Nabeshima, Akihiko Nishikimi, Yasumasa Ishida, Toshiaki Shigeoka, Johannes M Dijkstra
[ NAISTレポジトリ ] [ doi:10.3389/fimmu.2025.1573492 ]
"Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis ," Discovery Immunology, vol.4, no.1, 25 Dec. 2024
Ilamangai Nagaretnam, Yoshiya Kakimoto, Azusa Yoneshige, Fuka Takeuchi, Takayuki Sakimura, Kanato Sato, Yoshiro Osaki, Yuta Ishii, Ai Ozaki, Masaru Tamura, Michito Hamada, Toshiaki Shigeoka, Akihiko Ito, Yasumasa Ishida
[ NAISTレポジトリ ] [ doi:10.1093/discim/kyae018 ]
"Sensitization with an allogeneic MHC class I molecule induces anti-tumor immunity in the absence of PD-1 in mice," bioRxiv, 26 Aug. 2023
Komang Alit Paramitasari, Yasumasa Ishida
[ doi:10.1101/2023.08.26.554968 ]
"Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis," bioRxiv, 17 Aug. 2023
Ilamangai Nagaretnam, Azusa Yoneshige, Fuka Takeuchi, Ai Ozaki, Masaru Tamura, Shiori Suzuki, Toshiaki Shigeoka, Akihiko Ito, Yasumasa Ishida
[ doi:10.1101/2023.08.17.553694 ]
"Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression," Cell proliferation, vol.55, no.4, pp1-14, 17 Mar. 2022
Miki Nishio, Takuya Matsuura, Shunya Hibi, Shiomi Ohta, Chio Oka, Noriaki Sasai, Yasumasa Ishida, Eishou Matsuda
[ doi:10.1111/cpr.13215 ]
"PD-1: Its Discovery, Involvement in Cancer Immunotherapy, and Beyond," Cells, vol.9, 1 Jun. 2020
Yasumasa Ishida
[ NAISTレポジトリ ]
"Diphtheria toxin-mediated transposon-driven poly (A)-trapping efficiently disrupts transcriptionally silent genes in embryonic stem cells. ," Genesis, Jun. 2020
Yasumasa Ishida, Jie Bai, Ayako Isotani, Masashi Kawaichi, Ryohei Kondo, N. Ika Mayasari, Toshiaki Shigeoka, Masahito Ikawa, Goro Sashida
[ NAISTレポジトリ ]
"PD−1 発見の経緯と時代背景," 炎症と免疫, vol.28, no.3, pp14-17, 2020.3
石田 靖雅
"それでもわれわれが PD-1 を捨てられない理由," 実験医学, vol.36, no.9, pp1452-1456, 2018.5.18
石田 靖雅
"Collection of homozygous mutant mouse embryonic stem cells arising from autodiploidization during haploid gene trap mutagenesis," Nucleic Acids Research, 2018.3.16
Ayako Yamanishi, Atsushi Matsuba, Ryohei Kondo, Rie Akamatsu, Sachiyo Tanaka, Masahiro Tokunaga, Kyoji Horie, Chikara Kokubu, 石田 靖雅, Junji Takeda
[ doi:10.1093/nar/gky183 ]
"PD-1 による免疫学的「自己」の再定義," ファルマシア(日本薬学会誌), vol.53, no.10, pp967-969, 2017.10.1
石田 靖雅
"PD-1 の発見について語るときに私の語ること," 現代化学, vol.551, pp24-27, 2017.1.18
石田 靖雅
"CIBZ Regulates Mesodermal and Cardiac Differentiation of by Suppressing T and Mesp1 Expression in Mouse Embryonic Stem Cells," Scientific Reports, 23 Sep. 2016
Tomomi Kotoku, Koji Kosaka, Miki Nishio, Yasumasa Ishida, Masashi Kawaichi, Eisho Matsuda
[ doi:10.1038/srep34188 ]
"PD-1はこうして発見された," 肝胆膵, vol.73, no.3, pp317-322, 2016.8.31
石田 靖雅
"座談会「免疫チェックポイント阻害剤の基礎から臨床成績および開発動向」," 肝胆膵, vol.73, no.3, pp429-443, 2016.8.31
工藤正俊, 石田 靖雅, 池田公史, 田中真二
"哺乳類の発生や分化におけるメチル化DNA結合タンパク質の役割," Bio Clinica, vol.31, no.5, pp79-84, 2016.5
松田 永照, 西尾 美紀, 石田 靖雅
"新しいがん免疫療法:PD-1発見の経緯と研究の歴史," THE LUNG perspectives, vol.23, no.4, pp印刷中, 2015.10
石田 靖雅
"Low-cost three-dimensional gait analysis system for mice with an infrared depth sensor," Neuroscience Research, 10 Jul. 2015
Akihiro Nakamura, Hiroyuki Funaya, Naohiro Uezono, Kinichi Nakashima, Yasumasa Ishida, Tomohiro Suzuki, Shigeharu Wakana, Tomohiro Shibata
[ doi:10.1016/j.neures.2015.06.006 ]
"PD-1の発見から治療の標的分子へ," RCC INSIGHT, no.2015年3月号, pp10-11, 2015.3.10
石田 靖雅
"PD-1:発見の経緯と研究の歴史," Year Book of RCC 2014, pp35-41, 2015.2.6
石田 靖雅
"今明かすPD-1発見の舞台裏," 細胞工学, vol.33, no.10, pp1038-1041, 2014.9.22
石田靖雅
"今明かすPD-1発見の舞台裏," 細胞工学, vol.33, no.10, pp1038-1041, 2014.9.22
石田 靖雅
"An atypical tubulin kinase mediates stress-induced microtubule depolymerization in Arabidopsis.," Curr. Biol., vol.23, no.20, pp1969-1978, 2013.11
S. Fujita, J. Pytela, 堀田 崇, 加藤 壮英, T. Hamada, R. Akamatsu, 石田 靖雅, N. Kutsuna, S. Hasezawa, Y. Nomura, H. Nakagami, 橋本 隆
[ doi:10.1016/j.cub.2013.08.006 ]
"Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity.," Nucleic Acids Res., vol.40, no.14, pp6887, Aug. 2012
Shigeoka T, Kato S, Kawaichi M, Ishida Y.
"Mixture of differentially tagged Tol2 transposons accelerates conditional disruption of a broad spectrum of genes in mouse embryonic stem cells," Nucleic Acids Res., vol.40, no.13, ppe97, Jul. 2012
Mayasari NI, Mukougawa K, Shigeoka T, Kawaichi M, Ishida Y.
"CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog," Journal of Biological Chemistry, vol.287, no.15, pp12417-12424, 6 Apr. 2012
Tomonori Nishii, Yu Oikawa, Yasumasa Ishida, Masashi Kawaichi
[ NAISTレポジトリ ] [ doi:10.1074/jbc.M111.333856 ]
"Mixture of differentially tagged Tol2 transposons accelerates conditional disruption of a broad spectrum of genes in mouse embryonic stem cells," Nuc. Acid Res, Mar. 2012
Mayasari, Niluhputu, Mukougawa, Keiko, Shigeoka, Toshiaki, Kawaichi, Masashi, Ishida, Yasumasa
"The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression," Cell Research, 31 May. 2011
Eishou Matsuda, Yu Oikawa, Reiko Omori, Tomonori Nishii, Yasumasa Ishida, Masashi Kawaichi
[ NAISTレポジトリ ] [ doi:10.1038/cr.2011.90 ]
"Expression of a bacterial flagellin gene triggers plant immune responses and confers disease resistance in transgenic rice plants," Molecular Plant Pathology, vol.9, no.4, pp525, Jul. 2008
Takakura, Y, Che, F.-S, Ishida, Y, Tsutsumi, F, Kurotani, K.-I, Usami, S, Isogai, A, Imaseki, H.
[ doi:10.1111/j.1364-3703.2008.00477.x ]
"Down-regulation of CIBZ, a novel substrate of caspase-3, induces apoptosis," J. Biol. Chem., vol.283, pp14242, May. 2008
Yu Oikawa, Eishou Matsuda, Tomonori Nishii, Yasumasa Ishida, Masashi Kawaichi
[ NAISTレポジトリ ] [ doi:10.1074/jbc.M802257200 ]
"Mouse liaison for integrative brain research," Neurosci. Res., vol.58, pp103, Jun. 2007
Ishida, Yasumasa
[ doi:10.1016/j.neures.2007.02.012 ]
受賞
"JCA-CHAAO賞," 日本癌学会, 2014.9.27
石田靖雅
所属学協会
資料

松田 永照

職位 助教
領域 バイオサイエンス領域 メディカル生物学分野
研究室 機能ゲノム医学

哺乳類細胞の細胞周期制御、細胞老化、細胞分化、アポトーシス、オートファジー、幹細胞制御などに興味を持ち、腫瘍細胞の増殖、分化、生存を制御する分子メカニズムに関する研究・教育を行う。

重岡 稔章

職位 助教
領域 バイオサイエンス領域 メディカル生物学分野
研究室 機能ゲノム医学

哺乳類細胞の細胞周期制御、細胞老化、細胞分化、アポトーシス、オートファジー、幹細胞制御などに興味を持ち、腫瘍細胞の増殖、分化、生存を制御する分子メカニズムに関する研究・教育を行う。